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> Protein (NX_O43374)
Protein (NX_O43374)
Protein
Gene SymbolRASA4 to neXtProt (NX_O43374)
DescriptionRas GTPase-activating protein 4
Chromosome7
Location7q22.1 (102220093 ~ 102257204) to Ensembl
Sequene Features : Isoforms 2, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to calcium ion
.negative regulation of Ras protein signal transduction
.positive regulation of GTPase activity
  + 2 more...
.metal ion binding
.GTPase activator activity
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 18 0
2014-09-19protein level
2 11 0
2014-05-27transcript level
2 11 0
2014-02-25transcript level
2 11 0
2013-12-09transcript level
2 12 0
2013-11-01transcript level
2 11 0
2013-09-12transcript level
2 11 0
2013-08-17transcript level
2 11 0
2013-07-15transcript level
2 11 0
2013-06-11transcript level
2 11 0
2013-02-12transcript level
2 9 0
2012-12-20transcript level
2 9 0
2012-10-30transcript level
2 10 0
2012-10-07transcript level
2 10 0
2012-08-24transcript level
2 9 0
2012-07-28transcript level
2 9 0
2012-06-08transcript level
2 15 0
2012-05-07transcript level
2 15 0
2012-04-10transcript level
2 15 0
2012-01-13transcript level
2 15 0
2011-12-20transcript level
2 15 0
2011-11-11transcript level
2 15 0
2011-08-23transcript level
2 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43374-1
1 35 0 90400.3857
NX_O43374-2
0 35 0 85354.7784
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland91
ascites25
bladder33
blood89
bone41
brain89
cervix41
connective tissue53
embryonic tissue32
esophagus99
eye52
heart55
intestine34
kidney71
liver9
lung20
lymph node22
mammary gland26
mouth60
muscle56
nerve128
ovary39
pancreas56
parathyroid145
pharynx24
placenta21
prostate21
skin9
spleen56
testis57
thymus100
tonsil235
trachea96
uterus56
vascular38
Health State
TissuesTPM*
normal60
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor21
cervical tumor202
chondrosarcoma12
colorectal tumor62
esophageal tumor115
gastrointestinal tumor50
germ cell tumor11
glioma139
head and neck tumor82
kidney tumor87
leukemia52
liver tumor20
lung tumor19
lymphoma55
non-neoplasia93
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS62
retinoblastoma64
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult36
embryoid body100
blastocyst48
neonate32
fetus86
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.8
adrenal gland9.2
appendix13.3
bone marrow3.9
cerebral cortex16.6
colon9
duodenum14.5
esophagus8.3
gallbladder11.6
heart muscle4.6
kidney10.4
liver1.5
lung8.4
lymph node17.4
ovary13.1
pancreas5.7
placenta12.7
prostate8.4
salivary gland7.3
skin21.1
small intestine16.4
spleen19.3
stomach9
testis7.7
thyroid gland5.9
urinary bladder13.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607943, gene) Ras p21 protein activator 4; RASA4OMIM


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