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> Protein (NX_O43379)
Protein (NX_O43379)
Protein
Gene SymbolWDR62 to neXtProt (NX_O43379)
DescriptionWD repeat-containing protein 62
Chromosome19
Location19q13.12 (36545783 ~ 36596008) to Ensembl
Sequene Features : Isoforms 4, Variants 187, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neurogenesis
.cerebral cortex development
.N/A .cytoplasm
.nucleoplasm
.nucleus
.spindle pole
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 187 21
2014-09-19protein level
4 143 21
2014-05-27protein level
4 143 21
2014-02-25protein level
4 143 21
2013-12-09protein level
4 109 21
2013-11-01protein level
4 105 21
2013-09-12protein level
4 105 21
2013-08-17protein level
4 105 21
2013-07-15protein level
4 80 20
2013-06-11protein level
4 80 20
2013-02-12protein level
4 50 80
2012-12-20protein level
4 50 80
2012-10-30protein level
4 56 80
2012-10-07protein level
4 56 32
2012-08-24protein level
4 56 32
2012-07-28protein level
4 56 32
2012-06-08protein level
4 58 32
2012-05-07protein level
4 54 32
2012-04-10protein level
4 54 32
2012-01-13protein level
4 33 32
2011-12-20protein level
4 33 32
2011-11-11protein level
4 33 31
2011-08-23protein level
4 29 31
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43379-1
1 69 0 165848.9288
NX_O43379-2
2 24 0 53414.5368
NX_O43379-3
1 21 0 45710.0058
NX_O43379-4
1 69 0 166406.2123
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714790,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
2 EBI-714790,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
3 EBI-714790,EBI-10181968 P4HA3  
  .N/A .L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.iron ion binding
.procollagen-proline 4-dioxygenase activity
.endoplasmic reticulum lumen
4 EBI-714790,EBI-749432 DYRK2  
  .negative regulation of NFAT protein import into nucleus
.positive regulation of glycogen biosynthetic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 4 more...
.ubiquitin binding
.manganese ion binding
.ATP binding
  + 4 more...
.ribonucleoprotein complex
.cytoplasm
.nucleoplasm
  + 2 more...
5 EBI-714790,EBI-2853126 TBC1D23  
  .regulation of inflammatory response
.positive regulation of interleukin-6 production
.regulation of tumor necrosis factor production
.N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood16
bone13
brain10
embryonic tissue51
eye23
intestine8
kidney9
liver4
lung14
lymph90
lymph node111
muscle47
ovary19
pancreas9
placenta7
prostate10
skin9
stomach10
testis135
thymus37
uterus21
vascular19
Health State
TissuesTPM*
normal19
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor8
germ cell tumor22
glioma46
kidney tumor29
leukemia10
lung tumor48
lymphoma83
non-neoplasia10
pancreatic tumor19
primitive neuroectodermal tumor of the CNS62
prostate cancer9
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult11
embryoid body42
blastocyst97
neonate32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix2.4
bone marrow7.8
colon1
duodenum1.1
esophagus2
heart muscle6.8
lymph node3.3
skin2.3
small intestine1.1
spleen1.3
stomach1
testis53.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#604317, phenotype) Microcephaly 2, primary, autosomal recessive, with or without corticalOMIM
2(*613583, gene) Wd repeat-containing protein 62; WDR62OMIM


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