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> Protein (NX_O43390)
Protein (NX_O43390)
Protein
Gene SymbolHNRNPR to neXtProt (NX_O43390)
DescriptionHeterogeneous nuclear ribonucleoprotein R
Chromosome1
Location1p36.12 (23630264 ~ 23670829) to Ensembl
Sequene Features : Isoforms 4, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.ribonucleoprotein complex
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 66 7
2014-09-19protein level
4 49 7
2014-05-27protein level
4 49 10
2014-02-25protein level
3 49 9
2013-12-09protein level
3 39 9
2013-11-01protein level
3 34 7
2013-09-12protein level
3 34 7
2013-08-17protein level
3 34 7
2013-07-15protein level
2 16 6
2013-06-11protein level
2 16 6
2013-02-12protein level
2 3 16
2012-12-20protein level
2 3 16
2012-10-30protein level
2 4 16
2012-10-07protein level
2 4 8
2012-08-24protein level
2 2 8
2012-07-28protein level
2 2 8
2012-06-08protein level
2 2 8
2012-05-07protein level
2 2 8
2012-04-10protein level
2 2 8
2012-01-13protein level
2 4 8
2011-12-20protein level
2 4 8
2011-11-11protein level
2 4 7
2011-08-23protein level
2 4 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43390-1
0 25 7 70899.0466
NX_O43390-2
0 25 7 71170.199
NX_O43390-3
0 24 6 66938.072
NX_O43390-4
0 19 6 59915.6751
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713419,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-713419,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
3 EBI-713419,EBI-78738 PRMT1  
  .negative regulation of megakaryocyte differentiation
.histone H4-R3 methylation
.neuron projection development
  + 7 more...
.poly(A) RNA binding
.histone methyltransferase activity (H4-R3 specific)
.identical protein binding
  + 5 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites251
bladder100
blood188
bone195
bone marrow102
brain205
cervix288
connective tissue100
ear310
embryonic tissue324
esophagus347
eye196
heart89
intestine90
kidney137
larynx85
liver199
lung68
lymph180
lymph node122
mammary gland191
mouth226
muscle178
ovary187
pancreas112
parathyroid48
pharynx73
pituitary gland181
placenta151
prostate163
salivary gland246
skin175
spleen187
stomach94
testis135
thymus326
thyroid279
trachea115
umbilical cord145
uterus155
vascular329
Health State
TissuesTPM*
normal163
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor182
cervical tumor347
chondrosarcoma144
colorectal tumor88
esophageal tumor405
gastrointestinal tumor135
germ cell tumor334
glioma205
head and neck tumor239
kidney tumor145
leukemia127
liver tumor249
lung tumor38
lymphoma221
non-neoplasia103
ovarian tumor131
pancreatic tumor104
primitive neuroectodermal tumor of the CNS354
prostate cancer192
retinoblastoma366
skin tumor135
soft tissue/muscle tissue tumor159
uterine tumor133
Developmental Stage
TissuesTPM*
adult143
embryoid body271
blastocyst162
neonate514
fetus251
infant340
juvenile593
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue46.9
adrenal gland52.4
appendix75.3
bone marrow52.5
cerebral cortex52.1
colon59.3
duodenum45.9
esophagus51
gallbladder45.9
heart muscle37.1
kidney41.4
liver26.4
lung45.6
lymph node85.7
ovary70.7
pancreas25.6
placenta72
prostate53.1
salivary gland30.8
skin40.2
small intestine49.5
spleen53.6
stomach48.3
testis44.8
thyroid gland62.5
urinary bladder63.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607201, gene) Heterogeneous nuclear ribonucleoprotein r; HNRNPROMIM


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