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> Protein (NX_O43395)
Protein (NX_O43395)
Protein
Gene SymbolPRPF3 to neXtProt (NX_O43395)
DescriptionU4/U6 small nuclear ribonucleoprotein Prp3
Chromosome1
Location1q21.2 (150293925 ~ 150325671) to Ensembl
Sequene Features : Isoforms 2, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.U4/U6 x U5 tri-snRNP complex
.nuclear speck
.Cajal body
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 70 9
2014-09-19protein level
1 55 9
2014-05-27protein level
1 55 9
2014-02-25protein level
1 54 9
2013-12-09protein level
1 44 9
2013-11-01protein level
1 42 8
2013-09-12protein level
1 42 8
2013-08-17protein level
1 42 8
2013-07-15protein level
1 22 8
2013-06-11protein level
1 22 8
2013-02-12protein level
1 10 9
2012-12-20protein level
1 10 9
2012-10-30protein level
1 13 9
2012-10-07protein level
1 13 9
2012-08-24protein level
1 12 9
2012-07-28protein level
1 12 9
2012-06-08protein level
1 14 9
2012-05-07protein level
1 9 9
2012-04-10protein level
1 9 9
2012-01-13protein level
1 9 9
2011-12-20protein level
1 9 9
2011-11-11protein level
1 9 5
2011-08-23protein level
1 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43395-1
19 10 0 77480.707
NX_O43395-3
1 10 0 31868.8861
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744322,EBI-1052641 SMNDC1  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding .intermediate filament cytoskeleton
.nuclear speck
.Cajal body
  + 4 more...
2 EBI-744322,EBI-750559 SLU7  
  .cellular response to heat
.intracellular protein transport
.mRNA splicing, via spliceosome
  + 3 more...
.pre-mRNA 3'-splice site binding
.zinc ion binding
.second spliceosomal transesterification activity
.catalytic step 2 spliceosome
.intracellular membrane-bounded organelle
.small nuclear ribonucleoprotein complex
  + 6 more...
3 EBI-744322,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
4 EBI-744322,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
5 EBI-744322,EBI-749111 SF3B2  
  .viral process
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
6 EBI-744322,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
7 EBI-744322,EBI-721539 NKAP  
  .positive regulation of protein targeting to mitochondrion
.hematopoietic stem cell proliferation
.positive regulation of alpha-beta T cell differentiation
  + 7 more...
.poly(A) RNA binding
.chromatin DNA binding
.chromatin binding
.cytoplasm
.nucleoplasm
8 EBI-744322,EBI-739789 DVL3  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
9 EBI-744322,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites150
blood65
bone167
bone marrow41
brain62
cervix123
connective tissue53
ear62
embryonic tissue56
esophagus148
eye100
heart89
intestine64
kidney99
larynx170
liver19
lung68
lymph203
lymph node44
mammary gland66
mouth136
muscle131
nerve128
ovary49
pancreas56
parathyroid97
pharynx73
pituitary gland60
placenta84
prostate73
salivary gland49
skin66
spleen112
stomach73
testis57
thymus87
thyroid64
trachea57
uterus94
vascular58
Health State
TissuesTPM*
normal68
adrenal tumor79
breast (mammary gland) tumor75
cervical tumor173
chondrosarcoma84
colorectal tumor17
esophageal tumor173
gastrointestinal tumor84
germ cell tumor110
glioma55
head and neck tumor119
kidney tumor101
leukemia84
liver tumor20
lung tumor77
lymphoma152
non-neoplasia31
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS94
prostate cancer86
retinoblastoma107
skin tumor55
soft tissue/muscle tissue tumor135
uterine tumor66
Developmental Stage
TissuesTPM*
adult89
embryoid body42
blastocyst81
neonate96
fetus61
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.9
adrenal gland30.5
appendix38.9
bone marrow54
cerebral cortex26.8
colon23.6
duodenum25.4
esophagus19
gallbladder25.6
heart muscle15.1
kidney20.4
liver13.3
lung36.3
lymph node45.2
ovary45.2
pancreas14.3
placenta29.8
prostate33.8
salivary gland19.5
skin37
small intestine29.2
spleen44.5
stomach27
testis28.2
thyroid gland35
urinary bladder23.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#601414, phenotype) Retinitis pigmentosa 18; RP18OMIM
2(*607301, gene) Precursor mrna-processing factor 3, s. cerevisiae, homolog of; PRPF3OMIM


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