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> Protein (NX_O43463)
Protein (NX_O43463)
Protein
Gene SymbolSUV39H1 to neXtProt (NX_O43463)
DescriptionHistone-lysine N-methyltransferase SUV39H1
ChromosomeX
LocationXp11.23 (48553945 ~ 48567403) to Ensembl
Sequene Features : Isoforms 2, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 36 5
2014-09-19protein level
2 26 5
2014-05-27protein level
2 26 5
2014-02-25protein level
1 25 5
2013-12-09protein level
1 23 5
2013-11-01protein level
1 23 5
2013-09-12protein level
1 23 5
2013-08-17protein level
1 23 5
2013-07-15protein level
1 14 2
2013-06-11protein level
1 14 2
2013-02-12protein level
1 4 2
2012-12-20protein level
1 4 2
2012-10-30protein level
1 4 2
2012-10-07protein level
1 4 2
2012-08-24protein level
1 3 2
2012-07-28protein level
1 2 2
2012-06-08protein level
1 8 2
2012-05-07protein level
1 11 2
2012-04-10protein level
1 11 2
2012-01-13protein level
1 9 2
2011-12-20protein level
1 9 2
2011-11-11protein level
1 9 2
2011-08-23protein level
1 9 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43463-1
0 17 0 47876.559
NX_O43463-2
1 17 0 49116.2058
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-349968,EBI-8466445 CCDC151  
  .regulation of cilium assembly
.cell projection organization
.cilium movement
.N/A .ciliary basal body
.axoneme
.cilium
.centriole
2 EBI-349968,EBI-2008793 RRP8  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.positive regulation of cell cycle arrest
.regulation of transcription by glucose
  + 8 more...
.poly(A) RNA binding
.methylated histone binding
.S-adenosylmethionine-dependent methyltransferase activity
.rDNA heterochromatin
.plasma membrane
.cytoplasm
  + 4 more...
3 EBI-349968,EBI-1043378 ATE1  
  .protein arginylation .arginyltransferase activity .cytoplasm
.nucleus
4 EBI-349968,EBI-3923226 HOXC4  
  .cartilage development
.embryonic organ morphogenesis
.anterior/posterior pattern specification
.transcription, DNA-templated
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleus
5 EBI-349968,EBI-78219 CBX5  
  .negative regulation of transcription, DNA-templated
.viral process
.blood coagulation
.repressing transcription factor binding
.methylated histone binding
.protein binding, bridging
.chromatin binding
.histone methyltransferase complex
.nuclear pericentric heterochromatin
.transcriptional repressor complex
  + 8 more...
6 EBI-349968,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
7 EBI-349968,EBI-745579 CLK3  
  .protein autophosphorylation
.regulation of RNA splicing
.protein phosphorylation
.poly(A) RNA binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.intermediate filament cytoskeleton
.nuclear speck
.membrane
  + 3 more...
8 EBI-349968,EBI-960081 RASSF2  
  .negative regulation of NIK/NF-kappaB signaling
.homeostasis of number of cells
.bone remodeling
  + 6 more...
.N/A .cytoplasm
.nucleus
9 EBI-349968,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
10 EBI-349968,EBI-357598 PSMC1  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.poly(A) RNA binding
.proteasome-activating ATPase activity
.TBP-class protein binding
  + 2 more...
.cytosolic proteasome complex
.nuclear proteasome complex
.cell junction
  + 8 more...
11 EBI-349968,EBI-632461 U2AF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.metal ion binding
.poly(A) RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nuclear speck
.Cajal body
  + 2 more...
12 EBI-349968,EBI-781356 NR1H3  
  .positive regulation of cholesterol homeostasis
.regulation of cholesterol homeostasis
.negative regulation of secretion of lysosomal enzymes
  + 30 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.sterol response element binding
  + 6 more...
.RNA polymerase II transcription factor complex
.receptor complex
.nucleoplasm
  + 2 more...
13 EBI-349968,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
14 EBI-349968,EBI-530054 EZH2  
  .negative regulation of G1/S transition of mitotic cell cycle
.positive regulation of protein serine/threonine kinase activity
.protein localization to chromatin
  + 25 more...
.histone methyltransferase activity (H3-K27 specific)
.sequence-specific DNA binding
.histone methyltransferase activity
  + 7 more...
.pronucleus
.ESC/E(Z) complex
.cytoplasm
  + 3 more...
15 EBI-349968,EBI-2339674 PHF19  
  .positive regulation of histone H3-K27 methylation
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 4 more...
.methylated histone binding
.zinc ion binding
.nucleoplasm
16 EBI-349968,EBI-740686 DCAF8  
  .protein ubiquitination .N/A .Cul4-RING E3 ubiquitin ligase complex
.cytoplasm
.nucleus
17 EBI-349968,EBI-8466055 C8orf74  
  .N/A .N/A .N/A
18 EBI-349968,EBI-7962481 FGD5  
  .filopodium assembly
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 3 more...
.metal ion binding
.small GTPase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.ruffle membrane
.lamellipodium
.cytoskeleton
  + 5 more...
19 EBI-349968,EBI-8484990 STX19  
  .vesicle docking
.synaptic vesicle fusion to presynaptic membrane
.intracellular protein transport
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 2 more...
20 EBI-349968,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
21 EBI-349968,EBI-8472352 KLHDC4  
  .N/A .N/A .N/A
22 EBI-349968,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
23 EBI-349968,EBI-2659201 SPSB1  
  .intracellular signal transduction
.protein ubiquitination
.N/A .cytoplasm
24 EBI-349968,EBI-743290 HOOK2  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 3 more...
.identical protein binding .FHF complex
.microtubule
.centrosome
25 EBI-349968,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
26 EBI-349968,EBI-4395789 ZNF649  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
.extracellular space
27 EBI-349968,EBI-745276 ZNF670  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-349968,EBI-6115579 GTPBP2  
  .N/A .GTP binding
.GTPase activity
.intracellular membrane-bounded organelle
29 EBI-349968,EBI-1773949 CDCA4  
  .N/A .N/A .nucleus
30 EBI-349968,EBI-8489702 ZNF436  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleoplasm
31 EBI-349968,EBI-6597578 BCL11B  
  .olfactory bulb axon guidance
.thymus development
.alpha-beta T cell differentiation
  + 15 more...
.metal ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
32 EBI-349968,EBI-367363 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
33 EBI-349968,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
34 EBI-349968,EBI-867196 MBD1  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.methyl-CpG binding
.zinc ion binding
.transcription corepressor activity
  + 2 more...
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
35 EBI-349968,EBI-2876965 ZKSCAN5  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
blood89
bone41
bone marrow20
brain29
cervix82
connective tissue26
embryonic tissue37
eye23
heart22
intestine38
kidney23
liver19
lung20
lymph158
lymph node44
mammary gland19
mouth90
muscle47
ovary49
pancreas18
placenta35
prostate26
skin28
spleen37
stomach20
testis32
thymus100
uterus30
vascular19
Health State
TissuesTPM*
normal24
adrenal tumor79
breast (mammary gland) tumor21
cervical tumor86
colorectal tumor17
gastrointestinal tumor59
germ cell tumor83
glioma55
head and neck tumor37
kidney tumor14
leukemia63
liver tumor41
lung tumor48
lymphoma180
non-neoplasia31
ovarian tumor52
pancreatic tumor38
primitive neuroectodermal tumor of the CNS110
prostate cancer38
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult27
embryoid body42
blastocyst32
neonate64
fetus10
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.8
adrenal gland1.6
appendix4.4
bone marrow8.6
cerebral cortex3.8
colon3.1
duodenum2.5
esophagus3.3
gallbladder1.9
heart muscle2.9
kidney2.3
liver2.4
lung2.9
lymph node6.7
ovary3.6
placenta3.6
prostate2.2
salivary gland1.6
skin3.7
small intestine2.3
spleen4.3
stomach2.3
testis3.8
thyroid gland2.4
urinary bladder2.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*300254, gene) Suppressor of variegation 3-9, drosophila, homolog of, 1; SUV39H1OMIM


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