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> Protein (NX_O43490)
Protein (NX_O43490)
Protein
Gene SymbolPROM1 to neXtProt (NX_O43490)
DescriptionProminin-1
Chromosome4
Location4p15.32 (15964699 ~ 16086001) to Ensembl
Sequene Features : Isoforms 7, Variants 115, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nephron tubule epithelial cell differentiation
.glomerular parietal epithelial cell differentiation
.glomerular visceral epithelial cell differentiation
  + 4 more...
.cadherin binding
.actinin binding
.extracellular exosome
.photoreceptor outer segment membrane
.stereocilium
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 115 13
2014-09-19protein level
7 100 10
2014-05-27protein level
7 100 10
2014-02-25protein level
7 97 10
2013-12-09protein level
7 56 10
2013-11-01protein level
7 55 10
2013-09-12protein level
7 55 10
2013-08-17protein level
7 55 10
2013-07-15protein level
7 33 10
2013-06-11protein level
7 33 10
2013-02-12protein level
7 17 79
2012-12-20protein level
7 15 79
2012-10-30protein level
7 23 79
2012-10-07protein level
7 23 12
2012-08-24protein level
7 14 12
2012-07-28protein level
7 14 12
2012-06-08protein level
7 18 12
2012-05-07protein level
7 18 12
2012-04-10protein level
7 18 12
2012-01-13protein level
7 15 12
2011-12-20protein level
7 15 12
2011-11-11protein level
7 15 12
2011-08-23protein level
7 15 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43490-1
0 41 0 97139.7886
NX_O43490-2
0 40 0 96189.2114
NX_O43490-3
1 37 0 93209.8329
NX_O43490-4
0 38 0 93594.0801
NX_O43490-5
0 38 0 92681.6088
NX_O43490-6
0 39 0 93632.186
NX_O43490-7
0 39 0 94544.6573
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain25
embryonic tissue75
eye47
intestine60
kidney14
larynx42
liver9
lung26
mammary gland66
mouth15
muscle47
nerve64
ovary19
pancreas14
placenta31
stomach41
testis98
trachea1796
uterus17
Health State
TissuesTPM*
normal30
colorectal tumor71
gastrointestinal tumor25
germ cell tumor178
glioma18
head and neck tumor7
leukemia10
liver tumor10
ovarian tumor26
pancreatic tumor9
retinoblastoma43
uterine tumor44
Developmental Stage
TissuesTPM*
adult44
embryoid body28
blastocyst146
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix8.4
bone marrow3.5
cerebral cortex3.5
colon29.1
duodenum12.7
esophagus6.4
gallbladder37.9
heart muscle7.5
kidney21.5
liver1.5
lung3.9
pancreas9.9
placenta22.3
prostate3.3
salivary gland45
small intestine23.4
stomach29.6
testis12.6
thyroid gland4.2
urinary bladder6.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastMedium
bronchusMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
fallopian tubeMedium
gallbladderHigh
kidneyMedium
liverHigh
lungLow
nasopharynxMedium
pancreasMedium
placentaMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Low
small intestineMedium
smooth muscleLow
stomach 2Medium
thyroid glandMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#603786, phenotype) Stargardt disease 4; STGD4OMIM
2(*604365, gene) Prominin 1; PROM1OMIM
3(#608051, phenotype) Macular dystrophy, retinal, 2; MCDR2OMIM
4(#612095, phenotype) Retinitis pigmentosa 41; RP41OMIM
5(#612657, phenotype) Cone-rod dystrophy 12; CORD12OMIM


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