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> Protein (NX_O43493)
Protein (NX_O43493)
Protein
Gene SymbolTGOLN2 to neXtProt (NX_O43493)
DescriptionTrans-Golgi network integral membrane protein 2
Chromosome2
Location2p11.2 (85545147 ~ 85555548) to Ensembl
Sequene Features : Isoforms 6, Variants 62, PTMs 38 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .transport vesicle
.integral component of membrane
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 62 38
2014-09-19protein level
6 46 38
2014-05-27protein level
6 46 38
2014-02-25protein level
6 42 38
2013-12-09protein level
6 33 39
2013-11-01protein level
6 33 39
2013-09-12protein level
6 33 45
2013-08-17protein level
6 33 44
2013-07-15protein level
6 31 18
2013-06-11protein level
6 31 18
2013-02-12protein level
6 16 105
2012-12-20protein level
6 14 105
2012-10-30protein level
6 19 105
2012-10-07protein level
6 19 19
2012-08-24protein level
6 18 19
2012-07-28protein level
6 18 19
2012-06-08protein level
6 13 19
2012-05-07protein level
6 13 19
2012-04-10protein level
6 13 19
2012-01-13protein level
6 13 19
2011-12-20protein level
6 22 19
2011-11-11protein level
6 22 19
2011-08-23protein level
6 22 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43493-1
3 22 0 51082.2654
NX_O43493-2
0 22 0 45852.3863
NX_O43493-3
1 22 0 47745.3892
NX_O43493-4
0 18 0 39539.2153
NX_O43493-5
1 22 0 47029.971
NX_O43493-6
0 14 0 29523.478
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1752146,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1752146,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland91
ascites150
bladder133
blood261
bone349
bone marrow102
brain139
cervix20
connective tissue174
ear124
embryonic tissue93
eye134
heart134
intestine202
kidney213
larynx127
liver102
lung122
lymph22
lymph node144
mammary gland191
mouth211
muscle235
nerve128
ovary98
pancreas135
parathyroid291
pharynx73
placenta109
prostate105
salivary gland98
skin185
spleen168
stomach125
testis75
thymus200
thyroid300
trachea173
uterus124
vascular154
Health State
TissuesTPM*
normal142
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor182
cervical tumor28
chondrosarcoma289
colorectal tumor231
gastrointestinal tumor143
germ cell tumor113
glioma130
head and neck tumor141
kidney tumor275
leukemia243
liver tumor135
lung tumor48
lymphoma41
non-neoplasia196
ovarian tumor105
pancreatic tumor152
primitive neuroectodermal tumor of the CNS15
prostate cancer38
retinoblastoma64
skin tumor143
soft tissue/muscle tissue tumor39
uterine tumor133
Developmental Stage
TissuesTPM*
adult174
embryoid body142
blastocyst48
neonate193
fetus125
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue55.9
adrenal gland63.4
appendix75.9
bone marrow72.5
cerebral cortex53.8
colon81.6
duodenum90.8
esophagus36.6
gallbladder74.9
heart muscle45.4
kidney93.1
liver73.4
lung71.4
lymph node66.7
ovary54.4
pancreas24.6
placenta68.6
prostate60.1
salivary gland40.6
skin32.2
small intestine93.1
spleen72.6
stomach63.8
testis40.5
thyroid gland86.4
urinary bladder62
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603062, gene) Trans-golgi network protein 2; TGOLN2OMIM


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