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> Protein (NX_O43502)
Protein (NX_O43502)
Protein
Gene SymbolRAD51C to neXtProt (NX_O43502)
DescriptionDNA repair protein RAD51 homolog 3
Chromosome17
Location17q22 (56769934 ~ 56811703) to Ensembl
Sequene Features : Isoforms 2, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of G2/M transition of mitotic cell cycle
.blood coagulation
.spermatogenesis
  + 8 more...
.crossover junction endodeoxyribonuclease activity
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.perinuclear region of cytoplasm
.Rad51C-XRCC3 complex
.Rad51B-Rad51C-Rad51D-XRCC2 complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 57 1
2014-09-19protein level
2 50 1
2014-05-27protein level
2 50 1
2014-02-25protein level
2 49 1
2013-12-09protein level
2 44 1
2013-11-01protein level
2 43 1
2013-09-12protein level
2 43 1
2013-08-17protein level
2 43 1
2013-07-15protein level
2 34 1
2013-06-11protein level
2 34 1
2013-02-12protein level
2 25 0
2012-12-20protein level
2 25 0
2012-10-30protein level
2 27 0
2012-10-07protein level
2 27 0
2012-08-24protein level
2 27 0
2012-07-28protein level
2 27 0
2012-06-08protein level
2 24 0
2012-05-07protein level
2 20 0
2012-04-10protein level
1 20 0
2012-01-13protein level
1 20 0
2011-12-20protein level
1 20 0
2011-11-11protein level
1 20 0
2011-08-23protein level
1 20 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43502-1
11 7 0 42162.738
NX_O43502-2
0 7 0 14873.7061
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2267048,EBI-2824089 RAD51B  
  .positive regulation of G2/M transition of mitotic cell cycle
.blood coagulation
.reciprocal meiotic recombination
  + 3 more...
.DNA-dependent ATPase activity
.ATP binding
.single-stranded DNA binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.replication fork
.nucleoplasm
.nucleus
2 EBI-2267048,EBI-2849976 XRCC3  
  .positive regulation of mitotic cell cycle spindle assembly checkpoint
.resolution of mitotic recombination intermediates
.regulation of centrosome duplication
  + 5 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.perinuclear region of cytoplasm
.Rad51C-XRCC3 complex
.mitochondrion
  + 3 more...
3 EBI-2267048,EBI-3918457 XRCC2  
  .regulation of fibroblast apoptotic process
.centrosome organization
.positive regulation of neurogenesis
  + 11 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
.replication fork
4 EBI-2267048,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
5 EBI-2267048,EBI-297202 RAD51  
  .cellular response to camptothecin
.cellular response to ionizing radiation
.protein homooligomerization
  + 12 more...
.DNA polymerase binding
.single-stranded DNA-dependent ATPase activity
.identical protein binding
  + 5 more...
.perinuclear region of cytoplasm
.PML body
.microtubule organizing center
  + 10 more...
6 EBI-2267048,EBI-5281637 SWSAP1  
  .protein stabilization
.double-strand break repair via homologous recombination
.ATPase activity
.single-stranded DNA binding
.Shu complex
.nucleus
7 EBI-2267048,EBI-1222653 PALB2  
  .negative regulation of apoptotic process
.post-anal tail morphogenesis
.organ morphogenesis
  + 5 more...
.DNA binding .nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder33
blood32
bone13
bone marrow82
brain43
cervix61
connective tissue73
ear62
embryonic tissue9
eye38
heart22
intestine17
kidney56
liver38
lung17
lymph45
lymph node77
mammary gland66
muscle18
ovary19
pancreas14
parathyroid97
pharynx122
placenta52
prostate31
salivary gland49
skin104
stomach41
testis34
thymus12
uterus17
vascular38
Health State
TissuesTPM*
normal39
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor67
germ cell tumor22
glioma37
leukemia42
liver tumor62
lung tumor9
lymphoma41
non-neoplasia31
ovarian tumor26
primitive neuroectodermal tumor of the CNS62
prostate cancer19
retinoblastoma107
skin tumor39
soft tissue/muscle tissue tumor95
uterine tumor11
Developmental Stage
TissuesTPM*
adult42
blastocyst32
fetus37
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.4
adrenal gland21.7
appendix13.8
bone marrow17.5
cerebral cortex20.7
colon14
duodenum8.5
esophagus12.8
gallbladder13.6
heart muscle23.4
kidney15.1
liver9.6
lung12
lymph node24.2
ovary14.7
pancreas5.7
placenta17.6
prostate21.7
salivary gland8.2
skin10
small intestine7.7
spleen13.5
stomach9
testis34.1
thyroid gland13.2
urinary bladder17.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602774, gene) Rad51, s. cerevisiae, homolog of, c; RAD51COMIM
2(#613390, phenotype) Fanconi anemia, complementation group o; FANCOOMIM
3(#613399, phenotype) Breast-ovarian cancer, familial, susceptibility to, 3; BROVCA3OMIM


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