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> Protein (NX_O43516)
Protein (NX_O43516)
Protein
Gene SymbolWIPF1 to neXtProt (NX_O43516)
DescriptionWAS/WASL-interacting protein family member 1
Chromosome2
Location2q31.1 (175424300 ~ 175547644) to Ensembl
Sequene Features : Isoforms 4, Variants 88, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 88 9
2014-09-19protein level
4 73 9
2014-05-27protein level
4 73 9
2014-02-25protein level
4 73 9
2013-12-09protein level
4 63 9
2013-11-01protein level
4 61 9
2013-09-12protein level
4 61 9
2013-08-17protein level
4 61 9
2013-07-15protein level
4 43 9
2013-06-11protein level
4 43 9
2013-02-12protein level
4 18 12
2012-12-20protein level
4 18 12
2012-10-30protein level
4 19 12
2012-10-07protein level
4 19 4
2012-08-24protein level
4 13 4
2012-07-28protein level
4 13 4
2012-06-08protein level
4 16 4
2012-05-07protein level
4 16 4
2012-04-10protein level
4 16 4
2012-01-13protein level
4 10 4
2011-12-20protein level
4 10 4
2011-11-11protein level
4 10 4
2011-08-23protein level
4 10 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43516-1
0 23 0 51227.2197
NX_O43516-2
1 22 0 50250.5216
NX_O43516-3
1 22 0 51948.5935
NX_O43516-4
1 16 0 36403.5556
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346356,EBI-743923 WWP2  
  .regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 13 more...
.ligase activity
.transcription factor binding
.ubiquitin-protein transferase activity
.RNA polymerase II transcription factor binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
2 EBI-346356,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
3 EBI-346356,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
4 EBI-346356,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
5 EBI-346356,EBI-750369 HCLS1  
  .positive regulation of actin cytoskeleton reorganization
.negative regulation of leukocyte apoptotic process
.cellular response to cytokine stimulus
  + 17 more...
.protein kinase binding
.RNA polymerase II transcription factor binding
.membrane
.mitochondrion
.cytoplasm
  + 2 more...
6 EBI-346356,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
7 EBI-346356,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
8 EBI-346356,EBI-81134 SEC24C  
  .membrane organization
.COPII vesicle coating
.small molecule metabolic process
  + 7 more...
.zinc ion binding .perinuclear region of cytoplasm
.COPII vesicle coat
.ER to Golgi transport vesicle membrane
  + 3 more...
9 EBI-346356,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
10 EBI-346356,EBI-1754067 FASTK  
  .apoptotic signaling pathway
.regulation of RNA splicing
.protein phosphorylation
.Fas-activated serine/threonine kinase activity
.ATP binding
.protein serine/threonine kinase activity
.mitochondrion
11 EBI-346356,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood188
bone13
bone marrow82
brain15
connective tissue26
ear186
embryonic tissue32
esophagus49
eye19
heart33
intestine4
kidney18
larynx85
liver4
lung32
lymph270
lymph node590
mammary gland39
muscle18
nerve64
ovary78
pancreas42
parathyroid48
pharynx49
placenta31
prostate42
skin113
spleen56
stomach10
testis9
thymus62
thyroid64
tonsil293
trachea38
uterus25
vascular38
Health State
TissuesTPM*
normal53
adrenal tumor79
breast (mammary gland) tumor42
chondrosarcoma36
esophageal tumor57
gastrointestinal tumor8
germ cell tumor49
glioma37
head and neck tumor37
kidney tumor14
leukemia190
lung tumor9
lymphoma277
non-neoplasia72
ovarian tumor105
pancreatic tumor47
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor167
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult48
embryoid body85
blastocyst16
neonate32
fetus43
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.6
adrenal gland18.8
appendix112.6
bone marrow53.3
cerebral cortex16.7
colon22.1
duodenum21
esophagus15.7
gallbladder48
heart muscle12.9
kidney15.8
liver11.8
lung32.7
lymph node152.6
ovary14.2
pancreas3.5
placenta31.3
prostate16.5
salivary gland15.8
skin6.1
small intestine26.8
spleen96.8
stomach27.1
testis8.6
thyroid gland12.5
urinary bladder52
Tissues
TissuesExpression level
appendixMedium
bone marrowLow
lungLow
lymph nodeMedium
placentaLow
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602357, gene) Was/wasl-interacting protein family, member 1; WIPF1OMIM
2(#614493, phenotype) Wiskott-aldrich syndrome 2; WAS2OMIM


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