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> Protein (NX_O43520)
Protein (NX_O43520)
Protein
Gene SymbolATP8B1 to neXtProt (NX_O43520)
DescriptionPhospholipid-transporting ATPase IC
Chromosome18
Location18q21.31 (55313658 ~ 55470333) to Ensembl
Sequene Features : Isoforms 1, Variants 174, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.inner ear receptor cell development
.transmembrane transport
.negative regulation of transcription, DNA-templated
  + 9 more...
.cardiolipin binding
.ATP binding
.phospholipid-translocating ATPase activity
.magnesium ion binding
.stereocilium
.brush border membrane
.apical plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 174 3
2014-09-19protein level
1 145 3
2014-05-27protein level
1 143 3
2014-02-25protein level
1 143 3
2013-12-09protein level
1 123 3
2013-11-01protein level
1 121 3
2013-09-12protein level
1 121 2
2013-08-17protein level
1 121 2
2013-07-15protein level
1 90 2
2013-06-11protein level
1 90 2
2013-02-12protein level
1 60 1
2012-12-20protein level
1 57 1
2012-10-30protein level
1 66 1
2012-10-07protein level
1 66 1
2012-08-24protein level
1 60 1
2012-07-28protein level
1 60 1
2012-06-08protein level
1 61 1
2012-05-07protein level
1 61 1
2012-04-10protein level
1 61 1
2012-01-13protein level
1 61 1
2011-12-20protein level
1 61 1
2011-11-11protein level
1 61 1
2011-08-23protein level
1 61 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43520-1
44 0 3 143603.7236
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9524729,EBI-2836942 TMEM30A  
  .positive regulation of protein exit from endoplasmic reticulum
.phospholipid translocation
.protein localization to endosome
  + 2 more...
.N/A .transport vesicle membrane
.apical plasma membrane
.integral component of membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder234
blood16
bone13
bone marrow41
brain4
connective tissue6
embryonic tissue14
eye43
intestine56
kidney14
larynx42
liver29
lung35
lymph node11
mammary gland39
mouth30
muscle9
ovary19
pancreas28
pharynx24
placenta24
prostate31
salivary gland49
skin9
spleen37
stomach94
testis9
thyroid42
trachea57
uterus38
vascular19
Health State
TissuesTPM*
normal19
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor67
germ cell tumor11
glioma27
head and neck tumor22
leukemia10
liver tumor20
lung tumor9
non-neoplasia31
ovarian tumor13
pancreatic tumor38
prostate cancer19
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult31
embryoid body42
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.4
adrenal gland5.8
appendix11.6
cerebral cortex1.1
colon89.8
duodenum39
esophagus18
gallbladder26.3
heart muscle4.7
kidney9.9
liver5.6
lung9.4
lymph node2.2
ovary1.3
pancreas14.9
placenta8.6
prostate26.3
salivary gland21.1
skin7.6
small intestine49.3
spleen6.8
stomach55.1
testis1.3
thyroid gland30.6
urinary bladder40.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleLow
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#147480, phenotype) Cholestasis, intrahepatic, of pregnancy; ICPOMIM
2(#211600, phenotype) Cholestasis, progressive familial intrahepatic, 1; PFIC1OMIM
3(#243300, phenotype) Cholestasis, benign recurrent intrahepatic, 1; BRIC1OMIM
4(*602397, gene) Atpase, class i, type 8b, member 1; ATP8B1OMIM


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