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> Protein (NX_O43521)
Protein (NX_O43521)
Protein
Gene SymbolBCL2L11 to neXtProt (NX_O43521)
DescriptionBcl-2-like protein 11
Chromosome2
Location2q13 (111876955 ~ 111926024) to Ensembl
Sequene Features : Isoforms 20, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of fibroblast apoptotic process
.positive regulation of IRE1-mediated unfolded protein response
  + 42 more...
.N/A .BIM-BCL-2 complex
.BIM-BCL-xl complex
.extrinsic component of membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
20 30 1
2014-09-19protein level
20 24 1
2014-05-27protein level
20 24 1
2014-02-25protein level
20 24 1
2013-12-09protein level
20 23 1
2013-11-01protein level
20 22 1
2013-09-12protein level
20 22 2
2013-08-17protein level
20 22 2
2013-07-15protein level
20 14 2
2013-06-11protein level
20 14 2
2013-02-12protein level
20 5 23
2012-12-20protein level
20 5 23
2012-10-30protein level
20 5 23
2012-10-07protein level
20 5 3
2012-08-24protein level
20 4 3
2012-07-28protein level
20 4 3
2012-06-08protein level
20 4 3
2012-05-07protein level
20 4 3
2012-04-10protein level
20 4 3
2012-01-13protein level
17 1 3
2011-12-20protein level
17 1 3
2011-11-11protein level
17 1 3
2011-08-23protein level
17 1 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43521-1
0 9 0 22156.7094
NX_O43521-10
1 5 0 14448.6723
NX_O43521-11
0 6 0 14408.7026
NX_O43521-12
2 8 0 22634.2572
NX_O43521-13
1 1 0 4831.3631
NX_O43521-14
0 6 0 15015.0707
NX_O43521-15
0 4 0 8208.8115
NX_O43521-16
0 4 0 8815.1796
NX_O43521-17
1 3 0 12403.811
NX_O43521-18
0 4 0 11765.766
NX_O43521-19
0 6 0 17965.6571
NX_O43521-2
0 7 0 15956.8183
NX_O43521-20
1 1 0 8517.3599
NX_O43521-3
0 5 0 12708.4122
NX_O43521-4
0 8 0 18523.76
NX_O43521-5
0 6 0 12323.8689
NX_O43521-6
0 4 0 9075.4628
NX_O43521-7
0 4 0 9589.7727
NX_O43521-8
0 8 0 18803.8476
NX_O43521-9
0 4 0 9355.5504
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-526406,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
2 EBI-526420,EBI-372712 MIF  
  .positive regulation of chemokine (C-X-C motif) ligand 2 production
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.negative regulation of cell aging
  + 31 more...
.phenylpyruvate tautomerase activity
.chemoattractant activity
.cytokine receptor binding
  + 3 more...
.extracellular exosome
.vesicle
.cell surface
  + 4 more...
3 EBI-526406,EBI-10178634 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
4 EBI-526406,EBI-296739 GNB2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of gastrulation
.regulation of establishment of cell polarity
  + 30 more...
.poly(A) RNA binding
.protein homodimerization activity
.SH2 domain binding
  + 10 more...
.IRE1-RACK1-PP2A complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 11 more...
5 EBI-526406,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
6 EBI-526406,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
7 EBI-526406,EBI-1003422 MCL1  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of response to DNA damage stimulus
  + 10 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
.protein channel activity
.Bcl-2 family protein complex
.integral component of membrane
.membrane
  + 7 more...
8 EBI-526406,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
9 EBI-526406,EBI-700771 BAD  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood57
bone55
brain2
cervix20
connective tissue33
ear62
embryonic tissue42
eye52
heart55
intestine43
kidney23
liver19
lung32
lymph45
lymph node155
mammary gland6
mouth15
muscle18
nerve64
pancreas56
pituitary gland60
placenta38
prostate42
salivary gland49
skin14
spleen18
testis20
thymus62
thyroid42
trachea19
uterus12
vascular19
Health State
TissuesTPM*
normal39
cervical tumor28
chondrosarcoma72
colorectal tumor53
germ cell tumor22
glioma18
head and neck tumor22
leukemia63
liver tumor10
lymphoma27
non-neoplasia10
pancreatic tumor9
prostate cancer38
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult33
embryoid body85
blastocyst32
neonate32
fetus73
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.4
adrenal gland8.3
appendix17.7
bone marrow24.8
cerebral cortex4
colon13.8
duodenum6.9
esophagus8.6
gallbladder11.7
heart muscle4.5
kidney11.3
liver8.5
lung8.8
lymph node26.3
ovary11.8
pancreas5.8
placenta8.4
prostate9
salivary gland3.7
skin2.3
small intestine9.7
spleen14.8
stomach6.5
testis12.7
thyroid gland20.6
urinary bladder15
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603827, gene) Bcl2-like 11; BCL2L11OMIM


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