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> Protein (NX_O43541)
Protein (NX_O43541)
Protein
Gene SymbolSMAD6 to neXtProt (NX_O43541)
DescriptionMothers against decapentaplegic homolog 6
Chromosome15
Location15q22.31 (66994566 ~ 67074338) to Ensembl
Sequene Features : Isoforms 3, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of pathway-restricted SMAD protein phosphorylation
.fat cell differentiation
.response to estrogen
  + 14 more...
.type I activin receptor binding
.R-SMAD binding
.I-SMAD binding
  + 10 more...
.protein complex
.cytosol
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 43 6
2014-09-19protein level
3 28 6
2014-05-27protein level
3 28 6
2014-02-25protein level
3 28 2
2013-12-09protein level
3 20 2
2013-11-01protein level
3 18 2
2013-09-12protein level
3 18 2
2013-08-17protein level
3 18 2
2013-07-15protein level
3 12 2
2013-06-11protein level
3 12 2
2013-02-12protein level
3 11 5
2012-12-20protein level
3 9 5
2012-10-30protein level
3 11 5
2012-10-07protein level
3 11 2
2012-08-24protein level
3 11 2
2012-07-28protein level
3 11 2
2012-06-08protein level
3 12 2
2012-05-07protein level
3 11 2
2012-04-10protein level
3 11 2
2012-01-13protein level
3 8 2
2011-12-20protein level
3 8 2
2011-11-11protein level
3 8 1
2011-08-23protein level
3 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43541-1
0 20 0 53463.6661
NX_O43541-2
2 9 0 26218.9198
NX_O43541-4
2 11 0 35444.6973
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4324970,EBI-396676 STAMBP  
  .negative regulation of Ras protein signal transduction
.negative regulation of neuron apoptotic process
.protein deubiquitination
  + 4 more...
.metal ion binding
.protein domain specific binding
.metallopeptidase activity
.ubiquitin-specific protease activity
.extracellular exosome
.cleavage furrow
.plasma membrane
  + 4 more...
2 EBI-976374,EBI-4302903 PRKX  
  .regulation of epithelial cell differentiation involved in kidney development
.kidney morphogenesis
.epithelial tube morphogenesis
  + 10 more...
.ATP binding
.cAMP-dependent protein kinase activity
.cytoplasm
.nucleus
3 EBI-976374,EBI-976402 RUNX2  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.stem cell differentiation
  + 27 more...
.ATP binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 4 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
.nuclear chromatin
4 EBI-976374,EBI-1567153 SMAD1  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.positive regulation of cartilage development
  + 28 more...
.I-SMAD binding
.co-SMAD binding
.metal ion binding
  + 8 more...
.protein complex
.integral component of membrane
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
bone13
brain17
cervix82
connective tissue6
embryonic tissue14
eye14
heart67
intestine47
kidney85
lung92
mammary gland13
ovary128
pancreas51
parathyroid97
placenta49
skin37
stomach31
testis2
uterus34
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor25
germ cell tumor7
glioma74
leukemia10
non-neoplasia41
ovarian tumor170
primitive neuroectodermal tumor of the CNS15
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult27
embryoid body14
blastocyst16
fetus78
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland1.3
appendix2.2
cerebral cortex1.2
colon3.2
duodenum4.1
gallbladder4.4
heart muscle7.8
kidney6.4
liver3.3
lung20.8
lymph node1.7
ovary3
placenta10.8
prostate6.3
salivary gland1.2
small intestine2.6
spleen3.4
stomach6.4
testis2.2
thyroid gland12.5
urinary bladder5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602931, gene) Mothers against decapentaplegic, drosophila, homolog of, 6; SMAD6OMIM
2(#614823, phenotype) Aortic valve disease 2; AOVD2OMIM


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