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> Protein (NX_O43561)
Protein (NX_O43561)
Protein
Gene SymbolLAT to neXtProt (NX_O43561)
DescriptionLinker for activation of T-cells family member 1
Chromosome16
Location16p11.2 (28996147 ~ 29002104) to Ensembl
Sequene Features : Isoforms 5, Variants 30, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of protein kinase activity
  + 15 more...
.protein kinase binding
.SH3/SH2 adaptor activity
.membrane raft
.mast cell granule
.integral component of membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 30 19
2014-09-19protein level
5 22 19
2014-05-27protein level
5 22 19
2014-02-25protein level
2 20 19
2013-12-09protein level
2 13 19
2013-11-01protein level
2 12 19
2013-09-12protein level
2 12 19
2013-08-17protein level
2 12 19
2013-07-15protein level
2 10 18
2013-06-11protein level
2 10 18
2013-02-12protein level
2 5 40
2012-12-20protein level
2 4 40
2012-10-30protein level
2 6 40
2012-10-07protein level
2 6 20
2012-08-24protein level
2 6 20
2012-07-28protein level
2 6 20
2012-06-08protein level
2 11 20
2012-05-07protein level
2 10 20
2012-04-10protein level
2 10 20
2012-01-13protein level
2 9 20
2011-12-20protein level
2 9 20
2011-11-11protein level
2 9 20
2011-08-23protein level
2 9 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43561-1
0 10 0 27912.3227
NX_O43561-2
0 8 0 24969.8008
NX_O43561-3
2 7 0 28549.7361
NX_O43561-4
0 7 0 24813.7003
NX_O43561-5
0 9 0 27756.2222
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1222766,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-1222766,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-1222766,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
4 EBI-1222766,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
5 EBI-1222766,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
6 EBI-1222766,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
7 EBI-1222766,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood204
bone13
eye23
heart67
intestine43
kidney18
larynx42
liver14
lung11
mammary gland6
mouth15
muscle9
nerve64
ovary9
pancreas14
prostate5
skin9
spleen37
testis6
thymus288
thyroid42
tonsil58
uterus12
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor10
colorectal tumor71
germ cell tumor11
head and neck tumor29
leukemia137
ovarian tumor13
pancreatic tumor28
prostate cancer9
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult24
fetus19
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.2
adrenal gland6.8
appendix41.1
bone marrow18.9
cerebral cortex3.6
colon6.4
duodenum10.1
esophagus6.6
gallbladder15.2
heart muscle3.2
kidney5.1
liver2
lung19.6
lymph node105.1
ovary6.3
pancreas1.1
placenta6.3
prostate9
salivary gland9.2
skin11.8
small intestine14.3
spleen36.6
stomach13.6
testis3.9
thyroid gland6.7
urinary bladder18.5
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
lymph nodeHigh
spleenHigh
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602354, gene) Linker for activation of t cells; LATOMIM


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