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> Protein (NX_O43583)
Protein (NX_O43583)
Protein
Gene SymbolDENR to neXtProt (NX_O43583)
DescriptionDensity-regulated protein
Chromosome12
Location12q24.31 (123237321 ~ 123255611) to Ensembl
Sequene Features : Isoforms 1, Variants 8, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ribosome disassembly
.IRES-dependent translational initiation
.formation of translation preinitiation complex
.translation initiation factor activity .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 8 7
2014-09-19protein level
1 7 7
2014-05-27protein level
1 7 7
2014-02-25protein level
1 7 7
2013-12-09protein level
1 5 7
2013-11-01protein level
1 5 6
2013-09-12protein level
1 5 6
2013-08-17protein level
1 5 6
2013-07-15protein level
1 4 5
2013-06-11protein level
1 4 5
2013-02-12protein level
1 1 5
2012-12-20protein level
1 1 5
2012-10-30protein level
1 2 5
2012-10-07protein level
1 2 5
2012-08-24protein level
1 2 5
2012-07-28protein level
1 2 5
2012-06-08protein level
1 3 5
2012-05-07protein level
1 3 5
2012-04-10protein level
1 3 5
2012-01-13protein level
1 3 5
2011-12-20protein level
1 3 5
2011-11-11protein level
1 3 4
2011-08-23protein level
1 3 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43583-1
9 0 0 22078.0079
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716083,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-716083,EBI-347721 NELFB  
  .positive regulation of viral transcription
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.N/A .NELF complex
.cytoplasm
.nucleoplasm
3 EBI-716083,EBI-2341610 MARCH5  
  .negative regulation of cell aging
.positive regulation of mitochondrial fission
.regulation of mitochondrial fission
  + 3 more...
.GTPase binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites100
bladder234
blood24
bone41
bone marrow61
brain35
cervix61
connective tissue33
embryonic tissue169
esophagus49
eye62
heart67
intestine64
kidney47
larynx42
liver34
lung35
lymph node55
mammary gland66
mouth90
muscle65
nerve64
ovary49
pancreas46
parathyroid145
pharynx24
pituitary gland60
placenta52
prostate47
skin61
stomach20
testis45
thymus25
thyroid21
tonsil117
uterus56
vascular19
Health State
TissuesTPM*
normal51
bladder carcinoma227
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma60
colorectal tumor79
esophageal tumor57
gastrointestinal tumor67
germ cell tumor94
glioma46
head and neck tumor59
kidney tumor101
leukemia31
liver tumor52
lung tumor29
non-neoplasia41
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS39
prostate cancer38
retinoblastoma43
skin tumor63
soft tissue/muscle tissue tumor63
uterine tumor33
Developmental Stage
TissuesTPM*
adult56
embryoid body100
blastocyst130
neonate96
fetus35
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.6
adrenal gland21.6
appendix26.8
bone marrow14.8
cerebral cortex22.7
colon23.8
duodenum22.1
esophagus29.9
gallbladder22.1
heart muscle17.2
kidney21.9
liver13.8
lung17.2
lymph node32.9
ovary17.4
pancreas9.1
placenta26.3
prostate26.4
salivary gland18.9
skin25.4
small intestine21.7
spleen23.8
stomach21.2
testis15.7
thyroid gland27.4
urinary bladder28.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604550, gene) Density-regulated protein; DENROMIM


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