Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O43586)
Protein (NX_O43586)
Protein
Gene SymbolPSTPIP1 to neXtProt (NX_O43586)
DescriptionProline-serine-threonine phosphatase-interacting protein 1
Chromosome15
Location15q24.3 (77285700 ~ 77329673) to Ensembl
Sequene Features : Isoforms 2, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 52 2
2014-09-19protein level
2 47 2
2014-05-27protein level
2 47 2
2014-02-25protein level
2 47 2
2013-12-09protein level
2 32 2
2013-11-01protein level
2 32 2
2013-09-12protein level
2 32 2
2013-08-17protein level
2 32 2
2013-07-15protein level
2 26 2
2013-06-11protein level
2 26 2
2013-02-12protein level
2 19 0
2012-12-20protein level
2 15 0
2012-10-30protein level
2 22 0
2012-10-07protein level
2 22 0
2012-08-24protein level
2 22 0
2012-07-28protein level
2 22 0
2012-06-08protein level
2 26 0
2012-05-07protein level
2 23 0
2012-04-10protein level
2 23 0
2012-01-13protein level
2 17 0
2011-12-20protein level
2 17 0
2011-11-11protein level
2 12 0
2011-08-23protein level
2 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43586-1
2 18 0 47561.4948
NX_O43586-2
2 18 0 45325.431
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1050964,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-1050964,EBI-1050987 BUB3  
  .spindle assembly checkpoint
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 8 more...
.N/A .cytosol
.nucleoplasm
.condensed chromosome kinetochore
.kinetochore
3 EBI-1050964,EBI-5357290 TULP3  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.ganglion development
.smoothened signaling pathway involved in dorsal/ventral neural tube patterning
  + 14 more...
.phosphatidylinositol binding
.protein complex binding
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
.ciliary base
.primary cilium
.axoneme
  + 5 more...
4 EBI-1050964,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
5 EBI-1050964,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
6 EBI-1050964,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
7 EBI-1050964,EBI-716589 UBE2W  
  .cellular response to misfolded protein
.protein K11-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 3 more...
.cytoplasm
.nucleus
8 EBI-1050964,EBI-1384210 PTPN18  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity .cytoplasm
.nucleus
9 EBI-1050964,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
10 EBI-1050964,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
11 EBI-1050964,EBI-765817 TRAF3IP3  
  .N/A .N/A .integral component of membrane
12 EBI-1050964,EBI-1211241 PTPN22  
  .negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
13 EBI-1050964,EBI-3438881 ZNF175  
  .defense response to virus
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
14 EBI-1050964,EBI-372521 LSM4  
  .activation of mitophagy in response to mitochondrial depolarization
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 4 more...
.poly(A) RNA binding .small nuclear ribonucleoprotein complex
.cytosol
.U6 snRNP
.spliceosomal complex
15 EBI-1050964,EBI-10329013 PCDHB14  
  .calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
.synapse assembly
.synaptic transmission
.homophilic cell adhesion via plasma membrane adhesion molecules
.calcium ion binding .integral component of membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood179
bone13
bone marrow41
brain10
cervix20
connective tissue40
eye4
heart22
lung14
lymph node33
mammary gland6
muscle9
ovary29
placenta24
skin4
spleen187
stomach10
testis4
thymus175
trachea38
uterus25
vascular19
Health State
TissuesTPM*
normal19
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
gastrointestinal tumor8
glioma37
leukemia63
lung tumor19
lymphoma27
non-neoplasia51
skin tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult23
neonate64
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.7
adrenal gland4
appendix28.9
bone marrow53.5
cerebral cortex3.2
colon3.8
duodenum4.7
esophagus3.6
gallbladder9.1
heart muscle2.1
kidney1.5
liver1.9
lung8.5
lymph node34.1
ovary1.3
pancreas1
placenta4.8
prostate3.2
salivary gland4.2
skin3.2
small intestine5.6
spleen42.3
stomach5.6
testis2.2
thyroid gland1.7
urinary bladder10.4
Tissues
TissuesExpression level
appendixMedium
bone marrowHigh
colonMedium
lungLow
lymph nodeHigh
skin 1Low
soft tissue 1Low
soft tissue 2Low
spleenHigh
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#604416, phenotype) Pyogenic sterile arthritis, pyoderma gangrenosum, and acneOMIM
2(*606347, gene) Proline/serine/threonine phosphatase-interacting protein 1; PSTPIP1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center