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> Protein (NX_O43597)
Protein (NX_O43597)
Protein
Gene SymbolSPRY2 to neXtProt (NX_O43597)
DescriptionProtein sprouty homolog 2
Chromosome13
Location13q31.1 (80910111 ~ 80915086) to Ensembl
Sequene Features : Isoforms 1, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 39 1
2014-09-19protein level
1 30 1
2014-05-27protein level
1 30 1
2014-02-25protein level
1 29 1
2013-12-09protein level
1 24 1
2013-11-01protein level
1 24 1
2013-09-12protein level
1 24 1
2013-08-17protein level
1 24 1
2013-07-15protein level
1 16 1
2013-06-11protein level
1 16 1
2013-02-12protein level
1 8 2
2012-12-20protein level
1 8 2
2012-10-30protein level
1 9 2
2012-10-07protein level
1 9 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 6 2
2012-05-07protein level
1 6 2
2012-04-10protein level
1 6 2
2012-01-13protein level
1 5 2
2011-12-20protein level
1 5 2
2011-11-11protein level
1 5 2
2011-08-23protein level
1 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43597-1
16 0 0 34665.5798
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742487,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
2 EBI-742487,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
3 EBI-742487,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
4 EBI-742487,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
5 EBI-742487,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
6 EBI-742487,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
7 EBI-742487,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
8 EBI-742487,EBI-740418 GRAP2  
  .T cell receptor signaling pathway
.innate immune response
.Fc-epsilon receptor signaling pathway
  + 4 more...
.SH3/SH2 adaptor activity .cytosol
.endosome
.cytoplasm
  + 2 more...
9 EBI-742487,EBI-1754109 GP9  
  .platelet activation
.blood coagulation, intrinsic pathway
.blood coagulation
.cell adhesion
.N/A .integral component of plasma membrane
.plasma membrane
10 EBI-742487,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
11 EBI-742487,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
12 EBI-742487,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
13 EBI-742487,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
14 EBI-742487,EBI-2105393 UBASH3A  
  .negative regulation of T cell receptor signaling pathway
.regulation of cytokine production
.N/A .extracellular exosome
.cytosol
.nucleus
15 EBI-742487,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
16 EBI-742487,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
17 EBI-742487,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
18 EBI-742487,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
19 EBI-742487,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
20 EBI-742487,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
21 EBI-742487,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
22 EBI-742487,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
23 EBI-742487,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
24 EBI-742487,EBI-10245291 LCE3C  
  .keratinization .N/A .N/A
25 EBI-742487,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
26 EBI-742487,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
27 EBI-742487,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
28 EBI-742487,EBI-10246750 LCE2D  
  .keratinization .N/A .N/A
29 EBI-742487,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
30 EBI-742487,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
31 EBI-742487,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
32 EBI-742487,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
33 EBI-742487,EBI-1380492 UBASH3B  
  .negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
.nucleus
34 EBI-742487,EBI-747353 ATRIP  
  .DNA repair
.DNA replication
.DNA damage checkpoint
.K63-linked polyubiquitin binding .nucleoplasm
.nucleus
35 EBI-742487,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
36 EBI-742487,EBI-5460660 HEXIM2  
  .negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
37 EBI-742487,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
38 EBI-742487,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
39 EBI-742487,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
40 EBI-742487,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
41 EBI-742487,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
42 EBI-742487,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
43 EBI-742487,EBI-10302547 KRTAP4-7  
  .hair cycle
.aging
.N/A .keratin filament
44 EBI-742487,EBI-3918847 HSD3B7  
  .small molecule metabolic process
.bile acid metabolic process
.bile acid biosynthetic process
.cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
.3-beta-hydroxy-delta5-steroid dehydrogenase activity
.integral component of membrane
.endoplasmic reticulum membrane
45 EBI-742487,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
46 EBI-742487,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
47 EBI-742487,EBI-10314711 FAIM  
  .negative regulation of apoptotic process
.apoptotic process
.N/A .cytoplasm
48 EBI-742487,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
49 EBI-742487,EBI-77926 PACSIN3  
  .membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
50 EBI-742487,EBI-4291090 GNE  
  .carbohydrate phosphorylation
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.metal ion binding
.N-acylmannosamine kinase activity
.UDP-N-acetylglucosamine 2-epimerase activity
  + 2 more...
.cytosol
.cytoplasm
51 EBI-742487,EBI-2511991 USP20  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 4 more...
.zinc ion binding
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.G-protein coupled receptor binding
.perinuclear region of cytoplasm
.centrosome
52 EBI-742487,EBI-750484 FAM115A  
  .positive regulation of anion channel activity
.positive regulation of protein targeting to membrane
.negative regulation of cell migration
.transport
.ion channel binding .plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
bone27
brain30
connective tissue33
embryonic tissue46
eye71
heart11
intestine56
kidney14
larynx42
liver14
lung26
lymph22
mammary gland19
muscle56
nerve128
pancreas4
placenta14
prostate5
skin18
stomach62
testis4
uterus8
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor21
chondrosarcoma60
colorectal tumor44
gastrointestinal tumor84
germ cell tumor11
glioma37
head and neck tumor7
kidney tumor14
liver tumor31
lymphoma13
non-neoplasia41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult23
embryoid body42
blastocyst16
fetus43
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue48.1
adrenal gland25.9
appendix13.3
bone marrow19.7
cerebral cortex27.8
colon30.6
duodenum17.2
esophagus22.2
gallbladder34
heart muscle29.2
kidney17.3
liver17
lung24.4
lymph node9.2
ovary17
pancreas13.9
placenta11.7
prostate21.2
salivary gland26.7
skin11.7
small intestine21.9
spleen31.1
stomach11.8
testis5.3
thyroid gland16.7
urinary bladder16.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602466, gene) Sprouty, drosophila, homolog of, 2; SPRY2OMIM


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