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> Protein (NX_O43602)
Protein (NX_O43602)
Protein
Gene SymbolDCX to neXtProt (NX_O43602)
DescriptionNeuronal migration protein doublecortin
ChromosomeX
LocationXq23 (110537007 ~ 110655603) to Ensembl
Sequene Features : Isoforms 5, Variants 141, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 141 26
2014-09-19protein level
5 110 26
2014-05-27protein level
5 109 26
2014-02-25protein level
5 109 26
2013-12-09protein level
5 107 26
2013-11-01protein level
5 101 22
2013-09-12protein level
5 101 24
2013-08-17protein level
5 101 24
2013-07-15protein level
5 82 24
2013-06-11protein level
5 82 24
2013-02-12protein level
5 54 121
2012-12-20protein level
5 54 121
2012-10-30protein level
5 54 101
2012-10-07protein level
5 54 21
2012-08-24protein level
5 43 21
2012-07-28protein level
5 43 21
2012-06-08protein level
5 43 21
2012-05-07protein level
5 43 21
2012-04-10protein level
5 43 21
2012-01-13protein level
5 43 21
2011-12-20protein level
5 43 21
2011-11-11protein level
5 43 20
2011-08-23protein level
5 43 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43602-1
3 14 2 49286.2835
NX_O43602-2
0 15 2 40019.034
NX_O43602-3
1 14 2 40548.2095
NX_O43602-4
0 15 2 40118.1021
NX_O43602-5
1 14 2 40190.0979
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8646694,EBI-722671 ZBTB5  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-8646694,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-8646694,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
4 EBI-8646694,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
5 EBI-8646694,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-8646694,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
7 EBI-8646694,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
8 EBI-8646694,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
9 EBI-8646694,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-8646694,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
11 EBI-8646694,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
12 EBI-8646694,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
13 EBI-8646694,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain230
embryonic tissue18
eye43
lung38
mouth30
muscle37
placenta10
testis25
vascular38
Health State
TissuesTPM*
normal86
germ cell tumor186
glioma46
lung tumor48
primitive neuroectodermal tumor of the CNS15
Developmental Stage
TissuesTPM*
adult30
embryoid body14
fetus463
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex6.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#300067, phenotype) Lissencephaly, x-linked, 1; LISX1OMIM
2(*300121, gene) Doublecortin; DCXOMIM


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