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> Protein (NX_O43609)
Protein (NX_O43609)
Protein
Gene SymbolSPRY1 to neXtProt (NX_O43609)
DescriptionProtein sprouty homolog 1
Chromosome4
Location4q28.1 (124317950 ~ 124324910) to Ensembl
Sequene Features : Isoforms 1, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 45 2
2014-09-19protein level
1 31 2
2014-05-27protein level
1 31 2
2014-02-25protein level
1 31 1
2013-12-09protein level
1 27 1
2013-11-01protein level
1 27 1
2013-09-12protein level
1 27 1
2013-08-17protein level
1 27 1
2013-07-15protein level
1 15 0
2013-06-11protein level
1 15 0
2013-02-12protein level
1 13 1
2012-12-20protein level
1 13 1
2012-10-30protein level
1 16 1
2012-10-07protein level
1 16 1
2012-08-24protein level
1 16 1
2012-07-28protein level
1 16 1
2012-06-08protein level
1 16 1
2012-05-07protein level
1 10 1
2012-04-10protein level
1 10 1
2012-01-13protein level
1 5 1
2011-12-20protein level
1 5 1
2011-11-11protein level
1 5 1
2011-08-23protein level
1 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43609-1
16 0 0 35098.6977
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3866665,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-3866665,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
3 EBI-3866665,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
4 EBI-3866665,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
5 EBI-3866665,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
6 EBI-3866665,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
7 EBI-3866665,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
8 EBI-3866665,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
9 EBI-3866665,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
10 EBI-3866665,EBI-10246750 LCE2D  
  .keratinization .N/A .N/A
11 EBI-3866665,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
12 EBI-3866665,EBI-5460660 HEXIM2  
  .negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
13 EBI-3866665,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
14 EBI-3866665,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
15 EBI-3866665,EBI-10326419 R3HDM2  
  .N/A .poly(A) RNA binding .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder133
blood73
bone13
bone marrow41
brain10
cervix20
connective tissue13
embryonic tissue42
eye14
heart22
intestine47
kidney18
liver14
lung29
lymph node33
mammary gland59
mouth60
muscle47
nerve128
ovary19
pancreas79
pharynx49
placenta21
prostate47
skin18
stomach41
testis11
thymus12
trachea19
uterus34
vascular58
Health State
TissuesTPM*
normal34
bladder carcinoma170
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor35
gastrointestinal tumor33
germ cell tumor34
glioma37
head and neck tumor22
kidney tumor29
liver tumor10
lung tumor9
lymphoma27
non-neoplasia20
ovarian tumor13
pancreatic tumor76
primitive neuroectodermal tumor of the CNS7
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult30
embryoid body42
blastocyst32
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue107.3
adrenal gland41.4
appendix24.5
bone marrow14.8
cerebral cortex5.2
colon25.3
duodenum16.5
esophagus44.1
gallbladder82.3
heart muscle24.5
kidney18.8
liver13.1
lung44
lymph node12.9
ovary19.7
pancreas18.1
placenta33.3
prostate44.5
salivary gland25.7
skin16.7
small intestine16.7
spleen20.7
stomach28.2
testis12.1
thyroid gland54.8
urinary bladder66.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602465, gene) Sprouty, drosophila, homolog of, 1; SPRY1OMIM


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