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> Protein (NX_O43615)
Protein (NX_O43615)
Protein
Gene SymbolTIMM44 to neXtProt (NX_O43615)
DescriptionMitochondrial import inner membrane translocase subunit TIM44
Chromosome19
Location19p13.2 (7991603 ~ 8008805) to Ensembl
Sequene Features : Isoforms 1, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.protein import into mitochondrial matrix
.protein targeting to mitochondrion
.chaperone binding
.P-P-bond-hydrolysis-driven protein transmembrane transporter activity
.ATP binding
.mitochondrial matrix
.mitochondrial inner membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 57 5
2014-09-19protein level
1 43 5
2014-05-27protein level
1 43 5
2014-02-25protein level
1 43 4
2013-12-09protein level
1 30 4
2013-11-01protein level
1 29 1
2013-09-12protein level
1 29 1
2013-08-17protein level
1 29 1
2013-07-15protein level
1 19 1
2013-06-11protein level
1 19 1
2013-02-12protein level
1 13 1
2012-12-20protein level
1 13 1
2012-10-30protein level
1 15 1
2012-10-07protein level
1 15 1
2012-08-24protein level
1 13 1
2012-07-28protein level
1 13 1
2012-06-08protein level
1 15 1
2012-05-07protein level
1 15 1
2012-04-10protein level
1 15 1
2012-01-13protein level
1 11 1
2011-12-20protein level
1 11 1
2011-11-11protein level
1 11 1
2011-08-23protein level
1 11 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43615-1
25 0 0 51323.3064
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-861737,EBI-365961 ARAF  
  .negative regulation of apoptotic process
.positive regulation of peptidyl-serine phosphorylation
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.metal ion binding
.ATP binding
.receptor signaling protein activity
  + 2 more...
.N/A
2 EBI-861737,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland121
ascites376
bladder100
blood89
bone41
bone marrow61
brain88
cervix164
connective tissue114
embryonic tissue75
esophagus248
eye14
heart189
intestine64
kidney42
larynx42
liver131
lung50
lymph180
lymph node22
mammary gland72
mouth15
muscle159
nerve64
ovary68
pancreas51
pharynx24
pituitary gland121
placenta70
prostate58
skin42
spleen74
stomach52
testis94
thymus75
thyroid128
trachea38
umbilical cord217
uterus81
vascular77
Health State
TissuesTPM*
normal65
adrenal tumor79
breast (mammary gland) tumor85
cervical tumor173
chondrosarcoma48
colorectal tumor71
esophageal tumor173
gastrointestinal tumor168
germ cell tumor117
glioma102
head and neck tumor59
kidney tumor29
leukemia52
liver tumor145
lung tumor136
lymphoma110
non-neoplasia62
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS291
prostate cancer86
retinoblastoma43
skin tumor55
soft tissue/muscle tissue tumor223
uterine tumor22
Developmental Stage
TissuesTPM*
adult69
embryoid body42
blastocyst48
neonate96
fetus44
infant85
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.6
adrenal gland26.1
appendix27.1
bone marrow22.1
cerebral cortex23
colon25.2
duodenum29.7
esophagus22.5
gallbladder15.2
heart muscle40.9
kidney30.1
liver17
lung20.7
lymph node23.9
ovary22
pancreas13.9
placenta17.2
prostate25.5
salivary gland22.2
skin25.7
small intestine24.1
spleen28
stomach26.2
testis21.1
thyroid gland30
urinary bladder22.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleLow
liverHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateLow
rectumHigh
salivary glandLow
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605058, gene) Translocase of inner mitochondrial membrane 44, yeast, homolog of;OMIM


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