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> Protein (NX_O43633)
Protein (NX_O43633)
Protein
Gene SymbolCHMP2A to neXtProt (NX_O43633)
DescriptionCharged multivesicular body protein 2a
Chromosome19
Location19q13.43 (59062933 ~ 59066491) to Ensembl
Sequene Features : Isoforms 1, Variants 30, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of centriole elongation
.positive regulation of exosomal secretion
.positive regulation of viral release from host cell
  + 20 more...
.phosphatidylcholine binding
.protein domain specific binding
.extracellular exosome
.late endosome membrane
.membrane coat
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 30 11
2014-09-19protein level
1 26 11
2014-05-27protein level
1 26 11
2014-02-25protein level
1 26 11
2013-12-09protein level
1 22 11
2013-11-01protein level
1 20 7
2013-09-12protein level
1 20 7
2013-08-17protein level
1 20 7
2013-07-15protein level
1 11 3
2013-06-11protein level
1 11 3
2013-02-12protein level
1 2 3
2012-12-20protein level
1 2 3
2012-10-30protein level
1 3 3
2012-10-07protein level
1 3 3
2012-08-24protein level
1 2 3
2012-07-28protein level
1 2 3
2012-06-08protein level
1 6 3
2012-05-07protein level
1 6 3
2012-04-10protein level
1 6 3
2012-01-13protein level
1 6 3
2011-12-20protein level
1 6 3
2011-11-11protein level
1 6 3
2011-08-23protein level
1 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43633-1
6 0 0 25087.7821
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2692789,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood24
bone83
bone marrow61
brain47
cervix41
connective tissue26
ear124
embryonic tissue23
esophagus49
eye57
heart55
intestine56
kidney104
larynx85
liver58
lung89
lymph90
lymph node44
mammary gland46
mouth15
muscle28
ovary59
pancreas65
pituitary gland121
placenta70
prostate63
skin104
spleen37
stomach62
testis11
thymus12
thyroid42
tonsil58
umbilical cord72
uterus47
vascular77
Health State
TissuesTPM*
normal42
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma108
colorectal tumor71
esophageal tumor57
gastrointestinal tumor42
germ cell tumor49
glioma139
head and neck tumor29
kidney tumor72
leukemia21
liver tumor10
lung tumor77
lymphoma69
non-neoplasia20
ovarian tumor52
pancreatic tumor104
primitive neuroectodermal tumor of the CNS94
prostate cancer38
retinoblastoma21
skin tumor151
soft tissue/muscle tissue tumor23
uterine tumor99
Developmental Stage
TissuesTPM*
adult48
embryoid body28
blastocyst32
neonate32
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue86.4
adrenal gland109.5
appendix78.5
bone marrow91.8
cerebral cortex63.6
colon111.7
duodenum89.1
esophagus107.7
gallbladder81.8
heart muscle109.5
kidney106.5
liver74.2
lung83.4
lymph node73.9
ovary66.9
pancreas48.9
placenta89.5
prostate76.9
salivary gland90.6
skin109.4
small intestine94.7
spleen73.3
stomach99.9
testis60.9
thyroid gland115.3
urinary bladder88.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610893, gene) Chmp family, member 2a; CHMP2AOMIM


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