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> Protein (NX_O43639)
Protein (NX_O43639)
Protein
Gene SymbolNCK2 to neXtProt (NX_O43639)
DescriptionCytoplasmic protein NCK2
Chromosome2
Location2q12.2 (106361354 ~ 106510730) to Ensembl
Sequene Features : Isoforms 1, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 56 5
2014-09-19protein level
1 39 5
2014-05-27protein level
1 39 5
2014-02-25protein level
1 39 4
2013-12-09protein level
1 34 4
2013-11-01protein level
1 34 4
2013-09-12protein level
1 34 5
2013-08-17protein level
1 34 5
2013-07-15protein level
1 22 5
2013-06-11protein level
1 22 5
2013-02-12protein level
1 4 6
2012-12-20protein level
1 3 6
2012-10-30protein level
1 4 6
2012-10-07protein level
1 4 6
2012-08-24protein level
1 4 6
2012-07-28protein level
1 4 6
2012-06-08protein level
1 9 6
2012-05-07protein level
1 7 6
2012-04-10protein level
1 7 6
2012-01-13protein level
1 8 6
2011-12-20protein level
1 8 4
2011-11-11protein level
1 8 4
2011-08-23protein level
1 8 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43639-1
19 0 1 42888.4047
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713635,EBI-10184751 LRRIQ3  
  .N/A .N/A .N/A
2 EBI-713635,EBI-308663 ARHGAP32  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.postsynaptic membrane
.dendritic spine
.cell junction
  + 7 more...
3 EBI-713635,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
4 EBI-713635,EBI-1753267 FYB  
  .T cell receptor signaling pathway
.intracellular signal transduction
.signal transduction
  + 3 more...
.receptor binding .actin cytoskeleton
.cytosol
.nucleus
5 EBI-713635,EBI-740434 ZBTB7B  
  .cell differentiation
.positive regulation of gene expression
.ectoderm development
  + 3 more...
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
6 EBI-713635,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
7 EBI-713635,EBI-311323 SORBS2  
  .cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
8 EBI-713635,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
9 EBI-713635,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
10 EBI-713635,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
11 EBI-713635,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
12 EBI-713635,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
13 EBI-713635,EBI-718947 CHN1  
  .regulation of small GTPase mediated signal transduction
.regulation of axonogenesis
.ephrin receptor signaling pathway
  + 3 more...
.metal ion binding
.GTPase activator activity
.SH3/SH2 adaptor activity
.cytosol
14 EBI-713635,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
15 EBI-713635,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
16 EBI-713635,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
17 EBI-713635,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
18 EBI-713635,EBI-306928 LIMS1  
  .positive regulation of substrate adhesion-dependent cell spreading
.cellular response to transforming growth factor beta stimulus
.positive regulation of focal adhesion assembly
  + 7 more...
.protein kinase binding
.zinc ion binding
.perinuclear region of cytoplasm
.focal adhesion
.cell-cell junction
  + 2 more...
19 EBI-713635,EBI-7532268 EFNB2  
  .positive regulation of cardiac muscle cell differentiation
.regulation of chemotaxis
.ephrin receptor signaling pathway
  + 9 more...
.ephrin receptor binding .focal adhesion
.integral component of plasma membrane
.plasma membrane
20 EBI-713635,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
21 EBI-713635,EBI-929013 RASSF7  
  .signal transduction
.apoptotic process
.N/A .microtubule organizing center
.cytoplasm
22 EBI-713635,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
23 EBI-713635,EBI-711879 DDR1  
  .smooth muscle cell-matrix adhesion
.mammary gland alveolus development
.branching involved in mammary gland duct morphogenesis
  + 14 more...
.metal ion binding
.protein tyrosine kinase collagen receptor activity
.ATP binding
  + 2 more...
.extracellular exosome
.receptor complex
.integral component of plasma membrane
  + 2 more...
24 EBI-713635,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
25 EBI-713635,EBI-1307 PAK1  
  .negative regulation of cell proliferation involved in contact inhibition
.positive regulation of stress fiber assembly
.T cell receptor signaling pathway
  + 32 more...
.Rac GTPase binding
.ATP binding
.collagen binding
  + 2 more...
.protein complex
.ruffle membrane
.nuclear membrane
  + 12 more...
26 EBI-713635,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
27 EBI-713635,EBI-874629 NR5A1  
  .negative regulation of female gonad development
.positive regulation of male gonad development
.maintenance of protein location in nucleus
  + 14 more...
.sequence-specific DNA binding
.enzyme binding
.zinc ion binding
  + 8 more...
.nucleoplasm
.nucleus
28 EBI-713635,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
29 EBI-713635,EBI-712941 DRAP1  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
30 EBI-713635,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
31 EBI-713635,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
32 EBI-713635,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
33 EBI-713635,EBI-10244997 VARS2  
  .gene expression
.valyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.valine-tRNA ligase activity
.aminoacyl-tRNA editing activity
.mitochondrion
34 EBI-713635,EBI-3232077 RBM26  
  .negative regulation of phosphatase activity
.mRNA processing
.metal ion binding
.poly(A) RNA binding
.nucleotide binding
.N/A
35 EBI-713635,EBI-1638043 RHOU  
  .positive regulation of protein targeting to mitochondrion
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 5 more...
.metal ion binding
.GTP binding
.GTPase activity
.cell projection
.focal adhesion
.plasma membrane
  + 3 more...
36 EBI-713635,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
37 EBI-713635,EBI-746909 CPSF7  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
38 EBI-713635,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
39 EBI-713635,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
40 EBI-713635,EBI-8538631 RHOV  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.metal ion binding
.GTP binding
.endosome membrane
.plasma membrane
.cytosol
41 EBI-713635,EBI-10185081 FCRL2  
  .positive regulation of signal transduction
.cell-cell signaling
.SH3/SH2 adaptor activity .integral component of membrane
.plasma membrane
42 EBI-713635,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
43 EBI-713635,EBI-10183342 BCL11A  
  .negative regulation of dendrite development
.regulation of dendrite development
.positive regulation of collateral sprouting
  + 10 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
44 EBI-713635,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
45 EBI-713635,EBI-715945 RTN4  
  .regulation of branching morphogenesis of a nerve
.endoplasmic reticulum tubular network organization
.cardiac epithelial to mesenchymal transition
  + 11 more...
.poly(A) RNA binding .extracellular exosome
.neuronal cell body
.cell projection
  + 5 more...
46 EBI-713635,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
47 EBI-713635,EBI-1644252 FAM53C  
  .N/A .N/A .N/A
48 EBI-713635,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone41
bone marrow20
brain21
cervix61
connective tissue20
embryonic tissue28
eye57
heart33
intestine8
kidney37
liver9
lung29
lymph node22
mammary gland33
ovary68
pancreas42
placenta105
salivary gland148
skin308
spleen56
stomach52
testis18
thyroid64
tonsil58
uterus25
Health State
TissuesTPM*
normal22
bladder carcinoma56
breast (mammary gland) tumor42
chondrosarcoma60
gastrointestinal tumor42
germ cell tumor79
glioma121
head and neck tumor44
kidney tumor58
liver tumor20
lung tumor48
non-neoplasia10
ovarian tumor52
pancreatic tumor28
primitive neuroectodermal tumor of the CNS70
retinoblastoma64
skin tumor510
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult26
embryoid body28
blastocyst32
fetus34
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.6
adrenal gland12.4
appendix17.3
bone marrow9.8
cerebral cortex14.9
colon23.2
duodenum40.4
esophagus29.4
gallbladder22.2
heart muscle14.4
kidney16.9
liver4.6
lung19.5
lymph node22.6
ovary15.8
pancreas16.8
placenta29.3
prostate16.2
salivary gland32.2
skin12.9
small intestine39.3
spleen37.8
stomach20.4
testis23.4
thyroid gland18.4
urinary bladder20.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604930, gene) Nck adaptor protein 2; NCK2OMIM


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