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> Protein (NX_O43684)
Protein (NX_O43684)
Protein
Gene SymbolBUB3 to neXtProt (NX_O43684)
DescriptionMitotic checkpoint protein BUB3
Chromosome10
Location10q26.13 (124913793 ~ 124924886) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.spindle assembly checkpoint
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 8 more...
.N/A .cytosol
.nucleoplasm
.condensed chromosome kinetochore
.kinetochore
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 9
2014-09-19protein level
2 26 9
2014-05-27protein level
2 26 9
2014-02-25protein level
2 26 9
2013-12-09protein level
2 21 9
2013-11-01protein level
2 20 7
2013-09-12protein level
2 20 7
2013-08-17protein level
2 20 7
2013-07-15protein level
2 16 4
2013-06-11protein level
2 16 4
2013-02-12protein level
2 6 6
2012-12-20protein level
2 6 6
2012-10-30protein level
2 6 6
2012-10-07protein level
2 6 3
2012-08-24protein level
2 5 3
2012-07-28protein level
2 5 3
2012-06-08protein level
2 5 3
2012-05-07protein level
2 2 3
2012-04-10protein level
2 2 3
2012-01-13protein level
2 6 3
2011-12-20protein level
2 6 3
2011-11-11protein level
2 6 3
2011-08-23protein level
2 6 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43684-1
0 16 0 37131.0759
NX_O43684-2
0 16 0 36931.0144
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1050987,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-1050987,EBI-748936 BUB1  
  .positive regulation of intrinsic apoptotic signaling pathway
.spindle assembly checkpoint
.regulation of chromosome segregation
  + 11 more...
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytosol
.cytoplasm
  + 4 more...
3 EBI-1050987,EBI-1001438 BUB1B  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.cell division
  + 10 more...
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.spindle midzone
.perinuclear region of cytoplasm
.cytosol
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland242
ascites150
bladder301
blood122
bone111
bone marrow307
brain156
cervix61
connective tissue127
ear62
embryonic tissue201
esophagus49
eye95
heart122
intestine116
kidney94
larynx42
liver131
lung116
lymph112
lymph node345
mammary gland138
mouth332
muscle65
nerve193
ovary177
pancreas37
parathyroid145
pharynx540
pituitary gland60
placenta67
prostate79
salivary gland197
skin123
spleen131
stomach156
testis193
thymus175
thyroid42
trachea154
umbilical cord145
uterus107
vascular193
Health State
TissuesTPM*
normal119
adrenal tumor395
bladder carcinoma284
breast (mammary gland) tumor182
cervical tumor86
chondrosarcoma96
colorectal tumor186
esophageal tumor57
gastrointestinal tumor143
germ cell tumor136
glioma83
head and neck tumor209
kidney tumor116
leukemia137
liver tumor208
lung tumor175
lymphoma152
non-neoplasia82
ovarian tumor183
pancreatic tumor28
primitive neuroectodermal tumor of the CNS157
prostate cancer77
retinoblastoma129
skin tumor143
soft tissue/muscle tissue tumor127
uterine tumor66
Developmental Stage
TissuesTPM*
adult110
embryoid body100
blastocyst341
neonate160
fetus120
infant255
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.5
adrenal gland62.1
appendix71.1
bone marrow63.1
cerebral cortex33.9
colon49.9
duodenum45
esophagus51.5
gallbladder41.4
heart muscle24.9
kidney36.7
liver23
lung34.7
lymph node108.2
ovary45.9
pancreas14
placenta43
prostate40.7
salivary gland28.4
skin47.5
small intestine49.8
spleen57.1
stomach40.5
testis60.7
thyroid gland44.2
urinary bladder60.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603719, gene) Budding uninhibited by benzimidazoles 3, s. cerevisiae, homolog of;OMIM


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