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> Protein (NX_O43688)
Protein (NX_O43688)
Protein
Gene SymbolPPAP2C to neXtProt (NX_O43688)
DescriptionLipid phosphate phosphohydrolase 2
Chromosome19
Location19p13.3 (281040 ~ 291393) to Ensembl
Sequene Features : Isoforms 3, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.sphingolipid biosynthetic process
.dephosphorylation
.sphingolipid metabolic process
.phosphatidate phosphatase activity
.phosphoprotein phosphatase activity
.integral component of membrane
.membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 45 1
2014-09-19protein level
3 29 1
2014-05-27protein level
3 29 1
2014-02-25protein level
3 29 1
2013-12-09protein level
3 21 1
2013-11-01protein level
3 19 1
2013-09-12protein level
3 19 1
2013-08-17protein level
3 19 1
2013-07-15protein level
2 14 1
2013-06-11protein level
2 14 1
2013-02-12protein level
2 13 2
2012-12-20protein level
2 11 2
2012-10-30protein level
2 13 2
2012-10-07protein level
2 13 1
2012-08-24protein level
2 11 1
2012-07-28protein level
2 11 1
2012-06-08protein level
2 11 1
2012-05-07protein level
2 11 1
2012-04-10protein level
2 11 1
2012-01-13protein level
2 7 1
2011-12-20protein level
2 7 1
2011-11-11protein level
2 7 1
2011-08-23protein level
2 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43688-1
1 12 0 32552.5273
NX_O43688-2
2 12 0 34370.3343
NX_O43688-3
1 10 0 26086.1355
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-722017,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bone13
brain34
cervix41
connective tissue6
embryonic tissue28
esophagus49
eye52
intestine271
kidney28
liver14
lung50
mammary gland33
ovary108
pancreas79
pharynx24
pituitary gland121
placenta10
prostate26
salivary gland49
skin9
stomach52
testis13
uterus120
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma12
colorectal tumor444
esophageal tumor57
gastrointestinal tumor67
germ cell tumor7
kidney tumor14
liver tumor10
lung tumor58
non-neoplasia10
ovarian tumor144
pancreatic tumor161
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor95
uterine tumor110
Developmental Stage
TissuesTPM*
adult55
blastocyst32
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.1
adrenal gland1
appendix9
cerebral cortex12.1
colon39.4
duodenum54.5
esophagus13.9
gallbladder59.8
kidney2.6
liver1.3
lung10.8
lymph node1.6
ovary2
pancreas17.5
placenta3.8
prostate14.2
salivary gland84.1
skin45.3
small intestine45.9
spleen3
stomach49.9
testis6.7
thyroid gland3.9
urinary bladder32.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607126, gene) Phosphatidic acid phosphatase type 2c; PPAP2COMIM


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