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> Protein (NX_O43707)
Protein (NX_O43707)
Protein
Gene SymbolACTN4 to neXtProt (NX_O43707)
DescriptionAlpha-actinin-4
Chromosome19
Location19q13.2 (39138289 ~ 39222223) to Ensembl
Sequene Features : Isoforms 3, Variants 87, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of nucleic acid-templated transcription
.protein localization to tight junction
.tight junction assembly
  + 13 more...
.actin filament binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.protein complex
  + 13 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 87 17
2014-09-19protein level
3 66 17
2014-05-27protein level
3 66 26
2014-02-25protein level
3 66 24
2013-12-09protein level
3 54 24
2013-11-01protein level
3 51 17
2013-09-12protein level
2 51 17
2013-08-17protein level
1 54 17
2013-07-15protein level
1 36 16
2013-06-11protein level
1 36 16
2013-02-12protein level
1 14 11
2012-12-20protein level
1 15 11
2012-10-30protein level
1 17 11
2012-10-07protein level
1 17 11
2012-08-24protein level
1 16 11
2012-07-28protein level
1 16 11
2012-06-08protein level
1 28 11
2012-05-07protein level
1 26 11
2012-04-10protein level
1 26 11
2012-01-13protein level
1 19 11
2011-12-20protein level
1 19 11
2011-11-11protein level
1 19 7
2011-08-23protein level
1 19 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43707-1
5 31 18 104788.1763
NX_O43707-2
0 30 10 79863.276
NX_O43707-3
1 24 6 59541.9449
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351526,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
2 EBI-351526,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
3 EBI-351526,EBI-79553 TJP1  
  .cell-cell signaling involved in cell-cell junction organization
.establishment of endothelial intestinal barrier
.cellular response to glucose stimulus
  + 13 more...
.N/A .intercellular canaliculus
.apical part of cell
.apical junction complex
  + 12 more...
4 EBI-351526,EBI-746712 MYOZ2  
  .N/A .telethonin binding
.protein phosphatase 2B binding
.Z disc
.sarcomere
.actin cytoskeleton
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland60
ascites150
bladder334
blood245
bone335
bone marrow205
brain64
cervix144
connective tissue80
ear62
embryonic tissue371
esophagus297
eye181
heart78
intestine353
kidney185
larynx767
liver194
lung229
lymph22
lymph node211
mammary gland456
mouth105
muscle94
nerve450
ovary325
pancreas365
parathyroid97
pharynx220
pituitary gland60
placenta254
prostate648
skin308
spleen93
stomach209
testis45
thyroid536
umbilical cord72
uterus241
vascular96
Health State
TissuesTPM*
normal147
adrenal tumor158
bladder carcinoma284
breast (mammary gland) tumor515
cervical tumor144
chondrosarcoma289
colorectal tumor497
esophageal tumor347
gastrointestinal tumor210
germ cell tumor102
glioma139
head and neck tumor366
kidney tumor275
leukemia317
liver tumor239
lung tumor457
lymphoma13
non-neoplasia72
ovarian tumor406
pancreatic tumor628
primitive neuroectodermal tumor of the CNS102
prostate cancer953
retinoblastoma86
skin tumor319
soft tissue/muscle tissue tumor71
uterine tumor321
Developmental Stage
TissuesTPM*
adult330
embryoid body628
blastocyst276
neonate32
fetus100
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue221.3
adrenal gland162.3
appendix197.6
bone marrow127.1
cerebral cortex123.5
colon292.8
duodenum271
esophagus347.4
gallbladder163.9
heart muscle103.9
kidney281.4
liver105.3
lung278.2
lymph node106.3
ovary154.2
pancreas92.5
placenta276.7
prostate153.2
salivary gland147.3
skin191
small intestine302.6
spleen251.9
stomach227
testis60.1
thyroid gland187.3
urinary bladder229.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
kidneyMedium
liverHigh
lungMedium
lymph nodeLow
nasopharynxLow
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#603278, phenotype) Focal segmental glomerulosclerosis 1; FSGS1OMIM
2(*604638, gene) Actinin, alpha-4; ACTN4OMIM


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