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> Protein (NX_O43741)
Protein (NX_O43741)
Protein
Gene SymbolPRKAB2 to neXtProt (NX_O43741)
Description5'-AMP-activated protein kinase subunit beta-2
Chromosome1
Location1q21.1 (146626685 ~ 146644129) to Ensembl
Sequene Features : Isoforms 2, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 31 7
2014-09-19protein level
2 20 7
2014-05-27protein level
1 18 8
2014-02-25protein level
1 17 8
2013-12-09protein level
1 16 8
2013-11-01protein level
1 15 8
2013-09-12protein level
1 15 8
2013-08-17protein level
1 15 8
2013-07-15protein level
1 9 7
2013-06-11protein level
1 9 7
2013-02-12protein level
1 5 7
2012-12-20protein level
1 5 7
2012-10-30protein level
1 5 7
2012-10-07protein level
1 5 7
2012-08-24protein level
1 2 7
2012-07-28protein level
1 2 7
2012-06-08protein level
1 3 7
2012-05-07protein level
1 3 7
2012-04-10protein level
1 3 7
2012-01-13protein level
1 5 7
2011-12-20protein level
1 5 7
2011-11-11protein level
1 5 8
2011-08-23protein level
1 4 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43741-1
6 7 1 30283.1476
NX_O43741-2
1 7 1 21470.7652
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053424,EBI-10181162 CDX4  
  .labyrinthine layer development
.positive regulation of transcription from RNA polymerase II promoter
.anterior/posterior pattern specification
  + 2 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
2 EBI-1053424,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
3 EBI-1053424,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
4 EBI-1053424,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
5 EBI-1053424,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
6 EBI-1053424,EBI-357469 PYGM  
  .small molecule metabolic process
.glucose metabolic process
.glycogen catabolic process
  + 2 more...
.pyridoxal phosphate binding
.glycogen phosphorylase activity
.nucleotide binding
.extracellular exosome
.cytosol
.cytoplasm
7 EBI-1053424,EBI-3908043 DAO  
  .D-serine metabolic process
.D-alanine catabolic process
.glyoxylate metabolic process
  + 6 more...
.FAD binding
.cofactor binding
.protein dimerization activity
  + 2 more...
.cytosol
.peroxisomal matrix
.peroxisomal membrane
.peroxisome
8 EBI-1053424,EBI-3909284 GATA1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of transcription regulatory region DNA binding
.cellular response to thyroid hormone stimulus
  + 26 more...
.C2H2 zinc finger domain binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 12 more...
.transcriptional repressor complex
.transcription factor complex
.nucleoplasm
.nucleus
9 EBI-1053424,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
10 EBI-1053424,EBI-1181439 PRKAG1  
  .membrane organization
.protein heterooligomerization
.positive regulation of protein kinase activity
  + 12 more...
.ADP binding
.protein kinase binding
.AMP binding
  + 5 more...
.extracellular exosome
.AMP-activated protein kinase complex
.membrane
  + 2 more...
11 EBI-1053424,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
12 EBI-1053424,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
13 EBI-1053424,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
14 EBI-1053424,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
15 EBI-1053424,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
16 EBI-1053424,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
17 EBI-1053424,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
18 EBI-1053424,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
19 EBI-1053424,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
20 EBI-1053424,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
21 EBI-1053424,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
22 EBI-1053424,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
23 EBI-1053424,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
24 EBI-1053424,EBI-724373 BEND5  
  .N/A .N/A .Golgi apparatus
25 EBI-1053424,EBI-711823 GET4  
  .tail-anchored membrane protein insertion into ER membrane
.transport
.N/A .BAT3 complex
.cytosol
26 EBI-1053424,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
27 EBI-1053424,EBI-8484990 STX19  
  .vesicle docking
.synaptic vesicle fusion to presynaptic membrane
.intracellular protein transport
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 2 more...
28 EBI-1053424,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
29 EBI-1053424,EBI-746555 RHEBL1  
  .positive regulation of NF-kappaB transcription factor activity
.TOR signaling
.small GTPase mediated signal transduction
.metal ion binding
.GTP binding
.membrane
.endomembrane system
.cytoplasm
30 EBI-1053424,EBI-923440 GATAD2B  
  .ATP-dependent chromatin remodeling
.transcription, DNA-templated
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.protein complex
.nuclear speck
.nucleoplasm
.nuclear chromatin
31 EBI-1053424,EBI-6942903 CREB3L1  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.extracellular matrix constituent secretion
  + 3 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.cAMP response element binding
  + 2 more...
.integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
.nucleus
32 EBI-1053424,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
33 EBI-1053424,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
34 EBI-1053424,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
35 EBI-1053424,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
36 EBI-1053424,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
37 EBI-1053424,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
38 EBI-1053424,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
39 EBI-1053424,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
40 EBI-1053424,EBI-2796400 KLF15  
  .negative regulation of peptidyl-lysine acetylation
.cellular response to peptide
.glomerular visceral epithelial cell differentiation
  + 4 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
41 EBI-1053424,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
42 EBI-1053424,EBI-716006 MAGED1  
  .positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood8
bone83
brain35
cervix41
connective tissue26
ear124
embryonic tissue28
eye14
heart55
intestine21
kidney23
larynx42
liver77
lung38
mammary gland19
mouth15
muscle65
nerve64
ovary19
pancreas28
parathyroid48
placenta28
prostate15
skin18
spleen56
stomach31
testis27
thymus50
thyroid21
trachea96
uterus25
vascular19
Health State
TissuesTPM*
normal42
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma60
colorectal tumor17
germ cell tumor75
glioma18
head and neck tumor14
kidney tumor14
liver tumor31
lung tumor9
non-neoplasia62
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult28
embryoid body42
neonate32
fetus89
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.1
adrenal gland10
appendix8.9
bone marrow6.3
cerebral cortex14.5
colon10.8
duodenum31.1
esophagus11.4
gallbladder8
heart muscle21.1
kidney9
liver23.7
lung8.5
lymph node6.5
ovary11.4
pancreas18
placenta12.8
prostate14.6
salivary gland4.4
skin13.7
small intestine19.7
spleen7
stomach9.8
testis8
thyroid gland5.9
urinary bladder13.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverHigh
lungMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602741, gene) Protein kinase, amp-activated, noncatalytic, beta-2; PRKAB2OMIM


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