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> Protein (NX_O43752)
Protein (NX_O43752)
Protein
Gene SymbolSTX6 to neXtProt (NX_O43752)
DescriptionSyntaxin-6
Chromosome1
Location1q25.3 (180941861 ~ 180992047) to Ensembl
Sequene Features : Isoforms 2, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Golgi ribbon formation
.Golgi vesicle transport
.retrograde transport, endosome to Golgi
  + 4 more...
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.trans-Golgi network membrane
.SNARE complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 36 6
2014-09-19protein level
2 21 6
2014-05-27protein level
2 21 6
2014-02-25protein level
1 21 6
2013-12-09protein level
1 16 6
2013-11-01protein level
1 15 5
2013-09-12protein level
1 15 5
2013-08-17protein level
1 15 5
2013-07-15protein level
1 13 4
2013-06-11protein level
1 13 4
2013-02-12protein level
1 6 3
2012-12-20protein level
1 6 3
2012-10-30protein level
1 6 3
2012-10-07protein level
1 6 3
2012-08-24protein level
1 4 3
2012-07-28protein level
1 4 3
2012-06-08protein level
1 5 3
2012-05-07protein level
1 5 3
2012-04-10protein level
1 5 3
2012-01-13protein level
1 2 3
2011-12-20protein level
1 2 3
2011-11-11protein level
1 2 3
2011-08-23protein level
1 2 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43752-1
6 5 1 29157.7384
NX_O43752-2
0 5 1 17422.8548
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2695795,EBI-4401517 GOSR2  
  .membrane fusion
.vesicle fusion with Golgi apparatus
.cellular protein metabolic process
  + 7 more...
.SNAP receptor activity
.transporter activity
.SNARE binding
.late endosome membrane
.SNARE complex
.integral component of membrane
  + 5 more...
2 EBI-2695795,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
3 EBI-2695795,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
4 EBI-2695795,EBI-3921185 NAPB  
  .membrane fusion
.SNARE complex disassembly
.intracellular protein transport
.syntaxin binding
.soluble NSF attachment protein activity
.extracellular exosome
.SNARE complex
.vacuolar membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood8
bone69
bone marrow20
brain57
cervix41
connective tissue46
ear186
embryonic tissue28
esophagus49
eye28
heart22
intestine38
kidney9
larynx85
liver4
lung29
lymph node66
mammary gland39
mouth75
muscle47
nerve64
ovary19
pancreas9
pharynx24
placenta28
prostate26
salivary gland49
skin42
spleen18
testis50
thymus87
thyroid42
trachea38
uterus43
Health State
TissuesTPM*
normal46
breast (mammary gland) tumor32
chondrosarcoma60
colorectal tumor35
esophageal tumor57
germ cell tumor113
glioma102
head and neck tumor74
kidney tumor14
leukemia10
liver tumor72
lung tumor29
lymphoma55
non-neoplasia41
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS110
prostate cancer19
skin tumor47
soft tissue/muscle tissue tumor63
uterine tumor44
Developmental Stage
TissuesTPM*
adult35
embryoid body14
blastocyst32
fetus1
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.8
adrenal gland8.3
appendix13
bone marrow2.9
cerebral cortex17.9
colon9.1
duodenum7.1
esophagus16.8
gallbladder8.3
heart muscle4.8
kidney8.4
liver3.5
lung11.2
lymph node11.4
ovary8.7
pancreas2.3
placenta11.2
prostate7.8
salivary gland5
skin11.7
small intestine7.9
spleen9.6
stomach8.2
testis8.1
thyroid gland12.9
urinary bladder15.1
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603944, gene) Syntaxin 6; STX6OMIM


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