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> Protein (NX_O43765)
Protein (NX_O43765)
Protein
Gene SymbolSGTA to neXtProt (NX_O43765)
DescriptionSmall glutamine-rich tetratricopeptide repeat-containing protein alpha
Chromosome19
Location19p13.3 (2754712 ~ 2783369) to Ensembl
Sequene Features : Isoforms 1, Variants 29, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.viral process .N/A .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 29 14
2014-09-19protein level
1 22 14
2014-05-27protein level
1 22 14
2014-02-25protein level
1 20 14
2013-12-09protein level
1 16 14
2013-11-01protein level
1 13 13
2013-09-12protein level
1 13 13
2013-08-17protein level
1 13 13
2013-07-15protein level
1 7 6
2013-06-11protein level
1 7 6
2013-02-12protein level
1 3 6
2012-12-20protein level
1 3 6
2012-10-30protein level
1 2 6
2012-10-07protein level
1 2 6
2012-08-24protein level
1 1 6
2012-07-28protein level
1 1 6
2012-06-08protein level
1 1 6
2012-05-07protein level
1 1 6
2012-04-10protein level
1 1 6
2012-01-13protein level
1 0 6
2011-12-20protein level
1 1 6
2011-11-11protein level
1 1 6
2011-08-23protein level
1 1 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43765-1
13 0 0 34041.599
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347996,EBI-519160 TNFRSF13B  
  .negative regulation of B cell proliferation
.cell surface receptor signaling pathway
.hematopoietic progenitor cell differentiation
.B cell homeostasis
.receptor activity .external side of plasma membrane
.integral component of plasma membrane
2 EBI-347996,EBI-1222766 LAT  
  .regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of protein kinase activity
  + 15 more...
.protein kinase binding
.SH3/SH2 adaptor activity
.membrane raft
.mast cell granule
.integral component of membrane
  + 4 more...
3 EBI-347996,EBI-746479 ZG16  
  .protein transport .carbohydrate binding .cytoplasmic membrane-bounded vesicle lumen
.zymogen granule membrane
.extracellular matrix
  + 2 more...
4 EBI-347996,EBI-10188907 UPK3A  
  .urinary bladder development
.sodium ion homeostasis
.potassium ion homeostasis
  + 5 more...
.N/A .extracellular exosome
.apical plasma membrane
.integral component of membrane
.endoplasmic reticulum membrane
5 EBI-347996,EBI-355275 BAG2  
  .regulation of cellular response to heat
.cellular response to heat
.protein metabolic process
.protein folding
.identical protein binding .cytosol
6 EBI-347996,EBI-2564581 TXNDC12  
  .cell redox homeostasis .protein-disulfide reductase (glutathione) activity .endoplasmic reticulum lumen
7 EBI-347996,EBI-743414 EFEMP2  
  .extracellular matrix organization .calcium ion binding
.extracellular matrix structural constituent
.extracellular exosome
.vesicle
.basement membrane
.extracellular region
8 EBI-347996,EBI-1056240 CST1  
  .negative regulation of endopeptidase activity
.detection of chemical stimulus involved in sensory perception of bitter taste
.cysteine-type endopeptidase inhibitor activity .extracellular space
9 EBI-347996,EBI-1034374 TGFA  
  .mammary gland alveolus development
.positive regulation of epithelial cell proliferation
.positive regulation of mitotic nuclear division
  + 8 more...
.growth factor activity
.epidermal growth factor receptor binding
.perinuclear region of cytoplasm
.cytoplasmic vesicle
.basolateral plasma membrane
  + 5 more...
10 EBI-347996,EBI-751454 VIP  
  .prolactin secretion
.positive regulation of penile erection
.regulation of sensory perception of pain
  + 14 more...
.neuropeptide hormone activity
.hormone activity
.neuronal cell body
.extracellular region
11 EBI-347996,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
12 EBI-347996,EBI-355727 TFRC  
  .iron ion import
.transmembrane transport
.positive regulation of bone resorption
  + 5 more...
.poly(A) RNA binding
.identical protein binding
.transferrin receptor activity
.double-stranded RNA binding
.blood microparticle
.extracellular exosome
.recycling endosome
  + 14 more...
13 EBI-347996,EBI-355293 SLPI  
  .negative regulation of viral genome replication
.negative regulation of protein binding
.enzyme binding
.serine-type endopeptidase inhibitor activity
.endopeptidase inhibitor activity
.extracellular exosome
14 EBI-347996,EBI-355963 RPN1  
  .cellular protein metabolic process
.post-translational protein modification
.protein N-linked glycosylation via asparagine
  + 4 more...
.poly(A) RNA binding
.dolichyl-diphosphooligosaccharide-protein glycotransferase activity
.melanosome
.integral component of membrane
.membrane
  + 3 more...
15 EBI-347996,EBI-953978 SERPINE1  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of smooth muscle cell-matrix adhesion
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 33 more...
.receptor binding
.serine-type endopeptidase inhibitor activity
.protease binding
.extracellular exosome
.platelet alpha granule lumen
.extracellular matrix
  + 3 more...
16 EBI-347996,EBI-1220160 CTSL  
  .cellular response to thyroid hormone stimulus
.macrophage apoptotic process
.proteolysis involved in cellular protein catabolic process
  + 9 more...
.serpin family protein binding
.proteoglycan binding
.histone binding
  + 4 more...
.extracellular exosome
.lysosomal lumen
.endolysosome lumen
  + 4 more...
17 EBI-347996,EBI-10195681 MSMB  
  .N/A .N/A .nucleus
.extracellular space
18 EBI-347996,EBI-983038 COL1A2  
  .cellular response to amino acid stimulus
.protein heterotrimerization
.leukocyte migration
  + 14 more...
.platelet-derived growth factor binding
.metal ion binding
.identical protein binding
  + 2 more...
.extracellular exosome
.extracellular matrix
.endoplasmic reticulum lumen
  + 3 more...
19 EBI-347996,EBI-10195782 SOD3  
  .response to copper ion
.removal of superoxide radicals
.response to hypoxia
.response to reactive oxygen species
.zinc ion binding
.heparin binding
.copper ion binding
.superoxide dismutase activity
.extracellular exosome
.extracellular matrix
.trans-Golgi network
  + 5 more...
20 EBI-347996,EBI-2872294 CSF1  
  .positive regulation of glial cell migration
.positive regulation of macrophage colony-stimulating factor signaling pathway
.mammary duct terminal end bud growth
  + 33 more...
.protein homodimerization activity
.growth factor activity
.macrophage colony-stimulating factor receptor binding
.cytokine activity
.CSF1-CSF1R complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 5 more...
21 EBI-347996,EBI-8588553 GIP  
  .triglyceride homeostasis
.positive regulation of glucagon secretion
.long-term synaptic potentiation
  + 22 more...
.hormone activity .neuronal cell body
.secretory granule lumen
.endoplasmic reticulum lumen
  + 2 more...
22 EBI-347996,EBI-744915 SRGN  
  .negative regulation of cytokine secretion
.maintenance of granzyme B location in T cell secretory granule
.maintenance of protease location in mast cell secretory granule
  + 9 more...
.N/A .mast cell granule
.zymogen granule
.platelet alpha granule lumen
  + 4 more...
23 EBI-347996,EBI-723648 SPP1  
  .negative regulation of collateral sprouting of intact axon in response to injury
.response to steroid hormone
.decidualization
  + 11 more...
.extracellular matrix binding .extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 3 more...
24 EBI-347996,EBI-6624768 GAL  
  .negative regulation of root hair elongation
.positive regulation of large conductance calcium-activated potassium channel activity
.positive regulation of catagen
  + 16 more...
.type 3 galanin receptor binding
.type 2 galanin receptor binding
.type 1 galanin receptor binding
.neuropeptide hormone activity
.neuronal cell body
.secretory granule
.Golgi apparatus
  + 2 more...
25 EBI-347996,EBI-359252 PPIB  
  .chaperone-mediated protein folding
.bone development
.protein stabilization
  + 5 more...
.RNA polymerase binding
.unfolded protein binding
.poly(A) RNA binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
26 EBI-347996,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
27 EBI-347996,EBI-3913237 SDC4  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.positive regulation of focal adhesion assembly
  + 13 more...
.thrombospondin receptor activity .extracellular exosome
.membrane raft
.lysosomal lumen
  + 6 more...
28 EBI-347996,EBI-2873732 CD79B  
  .B cell receptor signaling pathway
.signal transduction
.immune response
.transmembrane signaling receptor activity .extracellular exosome
.B cell receptor complex
.external side of plasma membrane
  + 5 more...
29 EBI-347996,EBI-953909 PPIC  
  .protein folding
.protein peptidyl-prolyl isomerization
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.extracellular exosome
.cytoplasm
30 EBI-347996,EBI-347552 BAG6  
  .tail-anchored membrane protein insertion into ER membrane
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.protein stabilization
  + 17 more...
.proteasome binding
.ribosome binding
.ubiquitin protein ligase binding
.polyubiquitin binding
.BAT3 complex
.intracellular membrane-bounded organelle
.cytosol
  + 3 more...
31 EBI-347996,EBI-750892 HSPA13  
  .N/A .ATP binding .extracellular exosome
.intracellular membrane-bounded organelle
.endoplasmic reticulum
32 EBI-347996,EBI-10215061 CDH15  
  .positive regulation of muscle cell differentiation
.cell-cell junction organization
.muscle cell differentiation
  + 4 more...
.calcium ion binding .extracellular exosome
.neuromuscular junction
.integral component of membrane
  + 2 more...
33 EBI-347996,EBI-10216171 FXYD7  
  .regulation of sodium ion transmembrane transporter activity
.transmembrane transport
.ion transmembrane transport
.sodium channel regulator activity
.ion channel activity
.integral component of plasma membrane
.plasma membrane
34 EBI-347996,EBI-10224676 TFF3  
  .digestion
.defense response
.N/A .extracellular exosome
.cytoplasm
.proteinaceous extracellular matrix
.extracellular region
35 EBI-347996,EBI-10226799 SMAGP  
  .N/A .N/A .cytoplasmic vesicle membrane
.cell junction
.integral component of membrane
  + 2 more...
36 EBI-347996,EBI-536772 EFEMP1  
  .negative regulation of chondrocyte differentiation
.extracellular matrix organization
.peptidyl-tyrosine phosphorylation
  + 3 more...
.calcium ion binding
.epidermal growth factor receptor binding
.epidermal growth factor-activated receptor activity
.extracellular exosome
.extracellular space
.proteinaceous extracellular matrix
.extracellular region
37 EBI-347996,EBI-713684 NME3  
  .regulation of apoptotic process
.nucleoside triphosphate biosynthetic process
.apoptotic process
  + 5 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.extracellular exosome
.cytosol
.mitochondrion
38 EBI-347996,EBI-3931258 IRF5  
  .type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
.defense response to virus
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.regulatory region DNA binding
.cytosol
.cytoplasm
.nucleus
39 EBI-347996,EBI-2650369 IRF3  
  .programmed necrotic cell death
.macrophage apoptotic process
.cellular response to dsRNA
  + 28 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
40 EBI-347996,EBI-5663553 SGCA  
  .muscle organ development
.muscle contraction
.calcium ion binding .membrane raft
.sarcolemma
.integral component of membrane
  + 5 more...
41 EBI-347996,EBI-10243654 TTMP  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum membrane
42 EBI-347996,EBI-10244617 TMEM31  
  .N/A .N/A .integral component of membrane
43 EBI-347996,EBI-953819 ITPRIPL1  
  .N/A .N/A .integral component of membrane
.membrane
44 EBI-347996,EBI-10250491 LAIR2  
  .N/A .N/A .extracellular region
45 EBI-347996,EBI-2820477 TMUB2  
  .N/A .N/A .integral component of membrane
46 EBI-347996,EBI-359761 KTN1  
  .small GTPase mediated signal transduction
.microtubule-based movement
.poly(A) RNA binding .integral component of membrane
.membrane
.integral component of plasma membrane
  + 2 more...
47 EBI-347996,EBI-8650724 CARKD  
  .nicotinamide nucleotide metabolic process .ADP-dependent NAD(P)H-hydrate dehydratase activity
.ATP-dependent NAD(P)H-hydrate dehydratase activity
.ATP binding
.mitochondrion
48 EBI-347996,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
49 EBI-347996,EBI-750784 SPPL2A  
  .regulation of immune response
.membrane protein intracellular domain proteolysis
.membrane protein ectodomain proteolysis
.protein homodimerization activity
.aspartic-type endopeptidase activity
.integral component of lumenal side of endoplasmic reticulum membrane
.integral component of cytoplasmic side of endoplasmic reticulum membrane
.extracellular exosome
  + 4 more...
50 EBI-347996,EBI-3925742 AGR3  
  .N/A .dystroglycan binding .extracellular region
51 EBI-347996,EBI-10276729 TMEM174  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum membrane
52 EBI-347996,EBI-718622 C19orf10  
  .cellular response to brefeldin A
.positive regulation of protein kinase B signaling
.positive regulation of transcription from RNA polymerase II promoter
  + 11 more...
.N/A .extracellular exosome
.endoplasmic reticulum-Golgi intermediate compartment
.endoplasmic reticulum lumen
.extracellular space
53 EBI-347996,EBI-740845 PBXIP1  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.multicellular organismal development
.transcription corepressor activity .microtubule
.cytosol
.nucleus
54 EBI-347996,EBI-953772 ERP27  
  .N/A .N/A .endoplasmic reticulum lumen
.endoplasmic reticulum
55 EBI-347996,EBI-2116102 PRAP1  
  .N/A .N/A .extracellular region
56 EBI-347996,EBI-10183007 FERD3L  
  .regulation of neurogenesis
.cell development
.negative regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .nucleus
57 EBI-347996,EBI-751770 SYT11  
  .calcium ion-dependent exocytosis of neurotransmitter
.negative regulation of neurotransmitter secretion
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.synaptic vesicle membrane
.cell junction
.synaptic vesicle
  + 2 more...
58 EBI-347996,EBI-10301084 C1QTNF6  
  .protein heterotrimerization .N/A .extracellular space
.collagen trimer
59 EBI-347996,EBI-750200 C1QTNF1  
  .positive regulation of aldosterone secretion
.negative regulation of platelet aggregation
.protein heterotrimerization
  + 7 more...
.collagen binding .integral component of plasma membrane
.extracellular space
.collagen trimer
60 EBI-347996,EBI-10304067 TWSG1  
  .negative regulation of osteoblast differentiation
.camera-type eye development
.forebrain development
  + 8 more...
.N/A .extracellular exosome
.extracellular space
61 EBI-347996,EBI-751132 SYT4  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.negative regulation of calcium ion-dependent exocytosis
  + 4 more...
.clathrin binding
.syntaxin binding
.calcium ion binding
.phosphatidylserine binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuron projection
  + 5 more...
62 EBI-347996,EBI-10314666 EVA1B  
  .activation of mitophagy in response to mitochondrial depolarization .N/A .integral component of membrane
63 EBI-347996,EBI-10316321 WBP1L  
  .N/A .N/A .integral component of membrane
64 EBI-347996,EBI-10323452 RARRES3  
  .lipid catabolic process
.negative regulation of cell proliferation
.phospholipid metabolic process
.phospholipase A2 activity .integral component of membrane
65 EBI-347996,EBI-712273 PCDHA4  
  .nervous system development
.homophilic cell adhesion via plasma membrane adhesion molecules
.cell adhesion
.calcium ion binding .integral component of plasma membrane
66 EBI-347996,EBI-742600 F11R  
  .regulation of actin cytoskeleton reorganization
.regulation of membrane permeability
.establishment of endothelial intestinal barrier
  + 17 more...
.PDZ domain binding .extracellular exosome
.slit diaphragm
.cytoplasmic vesicle
  + 6 more...
67 EBI-347996,EBI-3918971 FKBP7  
  .chaperone-mediated protein folding
.protein peptidyl-prolyl isomerization
.FK506 binding
.calcium ion binding
.peptidyl-prolyl cis-trans isomerase activity
.endoplasmic reticulum membrane
.endoplasmic reticulum lumen
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites100
bladder33
blood122
bone111
bone marrow123
brain78
cervix226
connective tissue33
embryonic tissue89
esophagus99
eye167
intestine99
kidney47
liver4
lung101
lymph383
lymph node144
mammary gland92
mouth15
muscle84
nerve257
ovary137
pancreas107
pituitary gland60
placenta123
prostate105
salivary gland246
skin109
spleen18
stomach31
testis73
tonsil176
uterus99
Health State
TissuesTPM*
normal57
adrenal tumor79
breast (mammary gland) tumor107
cervical tumor115
chondrosarcoma48
colorectal tumor88
esophageal tumor115
gastrointestinal tumor160
germ cell tumor91
glioma158
head and neck tumor52
kidney tumor72
leukemia148
liver tumor10
lung tumor194
lymphoma290
non-neoplasia31
ovarian tumor39
pancreatic tumor180
primitive neuroectodermal tumor of the CNS314
prostate cancer144
retinoblastoma301
skin tumor143
soft tissue/muscle tissue tumor175
uterine tumor88
Developmental Stage
TissuesTPM*
adult95
embryoid body28
blastocyst179
fetus41
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.6
adrenal gland18.8
appendix18.7
bone marrow23.2
cerebral cortex33.2
colon20.3
duodenum25.2
esophagus24.3
gallbladder19
heart muscle38.9
kidney25.2
liver13.9
lung20.5
lymph node23.9
ovary31.2
pancreas22.4
placenta28.1
prostate24.1
salivary gland28.3
skin15.5
small intestine23
spleen28
stomach22.5
testis34.6
thyroid gland30.9
urinary bladder20.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasLow
parathyroid glandLow
placentaLow
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603419, gene) Small glutamine-rich tetratricopeptide repeat-containing protein,OMIM


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