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> Protein (NX_O43809)
Protein (NX_O43809)
Protein
Gene SymbolNUDT21 to neXtProt (NX_O43809)
DescriptionCleavage and polyadenylation specificity factor subunit 5
Chromosome16
Location16q12.2 (56463045 ~ 56486111) to Ensembl
Sequene Features : Isoforms 1, Variants 12, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.histone deacetylase binding
.protein homodimerization activity
  + 3 more...
.paraspeckles
.mRNA cleavage factor complex
.centrosome
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 12 11
2014-09-19protein level
1 6 11
2014-05-27protein level
1 6 11
2014-02-25protein level
1 6 9
2013-12-09protein level
1 6 9
2013-11-01protein level
1 6 9
2013-09-12protein level
1 6 9
2013-08-17protein level
1 6 9
2013-07-15protein level
1 5 5
2013-06-11protein level
1 5 5
2013-02-12protein level
1 1 7
2012-12-20protein level
1 1 7
2012-10-30protein level
1 1 7
2012-10-07protein level
1 1 7
2012-08-24protein level
1 0 7
2012-07-28protein level
1 0 7
2012-06-08protein level
1 13 7
2012-05-07protein level
1 13 7
2012-04-10protein level
1 13 7
2012-01-13protein level
1 13 7
2011-12-20protein level
1 14 7
2011-11-11protein level
1 14 7
2011-08-23protein level
1 14 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43809-1
11 0 0 26210.665
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355720,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-355720,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
3 EBI-355720,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-355720,EBI-358410 CPSF6  
  .protein tetramerization
.mRNA processing
.mRNA polyadenylation
.poly(A) RNA binding
.mRNA binding
.nucleotide binding
.paraspeckles
.ribonucleoprotein complex
.membrane
  + 3 more...
5 EBI-355720,EBI-2339854 CARM1  
  .endochondral bone morphogenesis
.response to cAMP
.positive regulation of fat cell differentiation
  + 16 more...
.lysine-acetylated histone binding
.transcription regulatory region DNA binding
.histone methyltransferase activity
  + 8 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
6 EBI-355720,EBI-746909 CPSF7  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites100
bladder100
blood130
bone153
bone marrow164
brain84
cervix123
connective tissue87
ear62
embryonic tissue159
eye86
heart100
intestine112
kidney71
liver29
lung92
lymph67
lymph node200
mammary gland218
mouth120
muscle103
nerve128
ovary68
pancreas74
parathyroid97
pharynx73
pituitary gland60
placenta141
prostate79
salivary gland98
skin104
stomach177
testis89
thymus37
thyroid214
tonsil58
trachea96
uterus150
vascular96
Health State
TissuesTPM*
normal88
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor311
cervical tumor173
chondrosarcoma181
colorectal tumor115
gastrointestinal tumor177
germ cell tumor159
glioma37
head and neck tumor141
kidney tumor116
leukemia169
liver tumor52
lung tumor87
lymphoma55
non-neoplasia51
ovarian tumor39
pancreatic tumor95
primitive neuroectodermal tumor of the CNS181
prostate cancer115
retinoblastoma21
skin tumor167
soft tissue/muscle tissue tumor199
uterine tumor110
Developmental Stage
TissuesTPM*
adult110
embryoid body142
blastocyst325
neonate32
fetus134
infant42
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.2
adrenal gland34.6
appendix36
bone marrow49.6
cerebral cortex44.2
colon36.4
duodenum41.1
esophagus34.4
gallbladder29
heart muscle25.6
kidney37.6
liver17.3
lung26.7
lymph node54.6
ovary54.6
pancreas18.5
placenta33.9
prostate29.3
salivary gland25.4
skin22.1
small intestine30.2
spleen32.2
stomach36.3
testis74.7
thyroid gland36.4
urinary bladder37.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604978, gene) Cleavage and polyadenylation specificity factor 5; CPSF5OMIM


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