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> Protein (NX_O43823)
Protein (NX_O43823)
Protein
Gene SymbolAKAP8 to neXtProt (NX_O43823)
DescriptionA-kinase anchor protein 8
Chromosome19
Location19p13.12 (15464196 ~ 15490609) to Ensembl
Sequene Features : Isoforms 1, Variants 110, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.signal transduction
.mitotic chromosome condensation
.mitotic nuclear division
.poly(A) RNA binding
.zinc ion binding
.double-stranded DNA binding
.nuclear matrix
.membrane
.Golgi apparatus
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 110 4
2014-09-19protein level
1 86 4
2014-05-27protein level
1 86 4
2014-02-25protein level
1 86 4
2013-12-09protein level
1 59 4
2013-11-01protein level
1 55 4
2013-09-12protein level
1 55 4
2013-08-17protein level
1 55 4
2013-07-15protein level
1 44 4
2013-06-11protein level
1 44 4
2013-02-12protein level
1 27 9
2012-12-20protein level
1 27 5
2012-10-30protein level
1 27 5
2012-10-07protein level
1 27 5
2012-08-24protein level
1 21 5
2012-07-28protein level
1 21 5
2012-06-08protein level
1 21 5
2012-05-07protein level
1 21 5
2012-04-10protein level
1 21 5
2012-01-13protein level
1 17 5
2011-12-20protein level
1 17 5
2011-11-11protein level
1 17 5
2011-08-23protein level
1 17 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43823-1
26 0 0 76060.8677
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
blood24
bone69
brain8
cervix41
connective tissue26
embryonic tissue51
eye23
heart44
intestine4
kidney28
larynx42
liver29
lung53
lymph node33
mammary gland6
mouth15
nerve64
ovary19
pancreas14
parathyroid48
placenta17
prostate36
skin23
stomach41
testis36
thymus12
thyroid64
umbilical cord72
uterus34
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma72
colorectal tumor8
gastrointestinal tumor33
germ cell tumor11
glioma9
head and neck tumor37
leukemia63
liver tumor10
lung tumor19
lymphoma13
pancreatic tumor28
prostate cancer19
skin tumor23
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult26
embryoid body85
blastocyst48
neonate32
fetus26
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.7
adrenal gland10.6
appendix15.5
bone marrow24.3
cerebral cortex7.2
colon11.7
duodenum12.8
esophagus9.9
gallbladder11.7
heart muscle8.2
kidney11.4
liver5.4
lung13.6
lymph node19.1
ovary15.3
pancreas5.6
placenta14.9
prostate13.6
salivary gland9.9
skin15.3
small intestine12.9
spleen18.3
stomach12.5
testis11.4
thyroid gland12
urinary bladder12.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604692, gene) A-kinase anchor protein 8; AKAP8OMIM


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