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> Protein (NX_O43829)
Protein (NX_O43829)
Protein
Gene SymbolZBTB14 to neXtProt (NX_O43829)
DescriptionZinc finger and BTB domain-containing protein 14
Chromosome18
Location18p11.31 (5289018 ~ 5297052) to Ensembl
Sequene Features : Isoforms 1, Variants 7, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 7 2
2014-09-19protein level
1 40 2
2014-05-27protein level
1 40 2
2014-02-25protein level
1 40 2
2013-12-09protein level
1 35 2
2013-11-01protein level
1 35 1
2013-09-12protein level
1 35 1
2013-08-17protein level
1 35 1
2013-07-15protein level
1 22 1
2013-06-11protein level
1 22 1
2013-02-12protein level
1 6 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 7 0
2012-10-07protein level
1 7 0
2012-08-24transcript level
1 3 0
2012-07-28transcript level
1 3 0
2012-06-08transcript level
1 5 0
2012-05-07transcript level
1 5 0
2012-04-10transcript level
1 5 0
2012-01-13transcript level
1 11 0
2011-12-20transcript level
1 11 0
2011-11-11transcript level
1 11 0
2011-08-23transcript level
1 11 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43829-1
21 0 0 50923.5595
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10176632,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-10176632,EBI-1053651 SNRPB2  
  .gene expression
.RNA splicing
.mRNA processing
  + 2 more...
.snRNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nucleolus
.U2 snRNP
  + 2 more...
3 EBI-10176632,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
4 EBI-10176632,EBI-747693 NAA10  
  .N-terminal peptidyl-glutamic acid acetylation
.N-terminal peptidyl-serine acetylation
.internal protein amino acid acetylation
  + 2 more...
.peptide-glutamate-N-acetyltransferase activity
.peptide-serine-N-acetyltransferase activity
.N-acetyltransferase activity
.NatA complex
.cytosolic ribosome
.membrane
  + 4 more...
5 EBI-10176632,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
6 EBI-10176632,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
7 EBI-10176632,EBI-354360 RPS7  
  .cellular protein metabolic process
.ribosomal small subunit biogenesis
.viral transcription
  + 11 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.small-subunit processome
.90S preribosome
  + 10 more...
8 EBI-10176632,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
9 EBI-10176632,EBI-726261 CDK16  
  .regulation of insulin secretion involved in cellular response to glucose stimulus
.neuron projection development
.growth hormone secretion
  + 3 more...
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein serine/threonine kinase activity
.neuron projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 5 more...
10 EBI-10176632,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
11 EBI-10176632,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
12 EBI-10176632,EBI-712181 MAD2L1BP  
  .regulation of exit from mitosis
.mitotic cell cycle checkpoint
.N/A .intracellular membrane-bounded organelle
.spindle
.cytoplasm
  + 2 more...
13 EBI-10176632,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
14 EBI-10176632,EBI-10238936 SYT16  
  .synaptic vesicle exocytosis
.vesicle fusion
.clathrin binding
.syntaxin binding
.phospholipid binding
.calcium ion binding
.plasma membrane
15 EBI-10176632,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
16 EBI-10176632,EBI-2680854 INTS3  
  .snRNA processing
.response to ionizing radiation
.mitotic cell cycle checkpoint
  + 2 more...
.N/A .SOSS complex
.integrator complex
.nucleus
17 EBI-10176632,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
18 EBI-10176632,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
19 EBI-10176632,EBI-3919850 CDKL3  
  .dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
20 EBI-10176632,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
21 EBI-10176632,EBI-750700 EIF1AD  
  .N/A .translation initiation factor activity .intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
22 EBI-10176632,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
23 EBI-10176632,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
24 EBI-10176632,EBI-769261 EAF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
25 EBI-10176632,EBI-741885 CEP19  
  .N/A .N/A .ciliary basal body
.centriole
.spindle pole
26 EBI-10176632,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
27 EBI-10176632,EBI-1045072 PNKP  
  .polynucleotide 3' dephosphorylation
.DNA 3' dephosphorylation involved in DNA repair
.nucleic acid phosphodiester bond hydrolysis
  + 9 more...
.ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
.polynucleotide 3'-phosphatase activity
.nucleotide kinase activity
  + 5 more...
.membrane
.nucleolus
.nucleoplasm
.nucleus
28 EBI-10176632,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
29 EBI-10176632,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
30 EBI-10176632,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
31 EBI-10176632,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
32 EBI-10176632,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
33 EBI-10176632,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
34 EBI-10176632,EBI-10321972 BAZ2B  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone27
bone marrow41
brain25
connective tissue20
ear621
embryonic tissue4
eye14
intestine8
kidney47
liver14
lung23
lymph node144
muscle18
pancreas23
parathyroid145
pituitary gland60
placenta28
skin9
spleen18
testis25
thymus50
thyroid85
uterus34
vascular19
Health State
TissuesTPM*
normal24
chondrosarcoma24
colorectal tumor17
germ cell tumor11
glioma9
head and neck tumor29
kidney tumor14
leukemia31
liver tumor31
lung tumor29
non-neoplasia10
pancreatic tumor47
primitive neuroectodermal tumor of the CNS15
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult22
fetus46
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8
adrenal gland8.3
appendix15.2
bone marrow6.3
cerebral cortex7.4
colon8.5
duodenum8.3
esophagus8.2
gallbladder11.1
heart muscle6.1
kidney9.3
liver5.5
lung9.9
lymph node22.5
ovary11.8
pancreas5.9
placenta7.3
prostate8.4
salivary gland7.8
skin11.2
small intestine9
spleen13.8
stomach10.3
testis6.6
thyroid gland13
urinary bladder9.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602126, gene) Zinc finger protein 161, mouse, homolog of; ZFP161OMIM


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