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> Protein (NX_O43865)
Protein (NX_O43865)
Protein
Gene SymbolAHCYL1 to neXtProt (NX_O43865)
DescriptionPutative adenosylhomocysteinase 2
Chromosome1
Location1p13.3 (110527308 ~ 110566357) to Ensembl
Sequene Features : Isoforms 2, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to calcium ion
.regulation of anion transport
.S-adenosylmethionine cycle
  + 6 more...
.hydrolase activity .extracellular exosome
.cytosol
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 46 6
2014-09-19protein level
2 31 6
2014-05-27protein level
2 31 6
2014-02-25protein level
2 30 5
2013-12-09protein level
2 28 5
2013-11-01protein level
2 27 5
2013-09-12protein level
2 27 8
2013-08-17protein level
2 27 8
2013-07-15protein level
2 12 7
2013-06-11protein level
2 12 7
2013-02-12protein level
2 3 16
2012-12-20protein level
2 3 16
2012-10-30protein level
2 3 16
2012-10-07protein level
2 3 9
2012-08-24protein level
2 3 9
2012-07-28protein level
2 3 9
2012-06-08protein level
2 5 9
2012-05-07protein level
2 9 9
2012-04-10protein level
2 9 9
2012-01-13protein level
2 6 9
2011-12-20protein level
2 6 9
2011-11-11protein level
2 6 9
2011-08-23protein level
2 6 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43865-1
3 12 12 58913.2758
NX_O43865-2
0 12 12 53718.7525
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2371423,EBI-750973 PSMD9  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteasome regulatory particle assembly
  + 26 more...
.bHLH transcription factor binding
.transcription coactivator activity
.proteasome regulatory particle
.cytosol
.cytoplasm
  + 2 more...
2 EBI-2371423,EBI-368321 PPL  
  .keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
3 EBI-2371423,EBI-742973 SOX30  
  .response to corticosteroid
.spermatogenesis
.transcription from RNA polymerase II promoter
  + 3 more...
.sequence-specific DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
4 EBI-2371423,EBI-711290 CDKN2C  
  .negative regulation of protein serine/threonine kinase activity
.oligodendrocyte differentiation
.negative regulation of phosphorylation
  + 6 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
5 EBI-2371423,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
6 EBI-2371423,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
7 EBI-2371423,EBI-1759386 SLC23A1  
  .transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
8 EBI-2371423,EBI-10186082 DACH1  
  .negative regulation of DNA biosynthetic process
.negative regulation of cell proliferation involved in contact inhibition
.negative regulation of fibroblast proliferation
  + 7 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
.intracellular membrane-bounded organelle
.cytoplasm
.nucleolus
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites175
bladder100
blood81
bone111
bone marrow61
brain247
cervix350
connective tissue73
ear62
embryonic tissue117
esophagus198
eye119
heart33
intestine77
kidney118
larynx42
liver92
lung83
lymph225
lymph node33
mammary gland85
mouth60
muscle75
nerve257
ovary118
pancreas149
pharynx196
pituitary gland242
placenta158
prostate68
salivary gland49
skin142
spleen18
stomach62
testis144
thymus37
thyroid107
trachea57
umbilical cord145
uterus86
vascular77
Health State
TissuesTPM*
normal120
adrenal tumor237
bladder carcinoma113
breast (mammary gland) tumor75
cervical tumor492
chondrosarcoma193
colorectal tumor71
esophageal tumor231
gastrointestinal tumor101
germ cell tumor159
glioma139
head and neck tumor104
kidney tumor130
leukemia52
liver tumor124
lung tumor38
lymphoma166
non-neoplasia113
ovarian tumor118
pancreatic tumor171
primitive neuroectodermal tumor of the CNS94
prostate cancer86
retinoblastoma193
skin tumor159
soft tissue/muscle tissue tumor63
uterine tumor133
Developmental Stage
TissuesTPM*
adult111
embryoid body100
blastocyst81
neonate96
fetus50
infant42
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue56.4
adrenal gland64.4
appendix33.6
bone marrow9.4
cerebral cortex133.7
colon46.8
duodenum108.1
esophagus48.8
gallbladder67.9
heart muscle32.5
kidney78.8
liver34.6
lung40
lymph node30.3
ovary40.5
pancreas37.2
placenta50.5
prostate40.3
salivary gland36.2
skin31.3
small intestine58.3
spleen30.6
stomach50.6
testis32
thyroid gland76.4
urinary bladder56.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607826, gene) S-adenosylhomocysteine hydrolase-like 1; AHCYL1OMIM


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