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> Protein (NX_O43913)
Protein (NX_O43913)
Protein
Gene SymbolORC5 to neXtProt (NX_O43913)
DescriptionOrigin recognition complex subunit 5
Chromosome7
Location7q22.1 (103766788 ~ 103848495) to Ensembl
Sequene Features : Isoforms 2, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.ATP binding
.DNA replication origin binding
.nucleotide binding
.cytoplasm
.nuclear origin of replication recognition complex
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 46 2
2014-09-19protein level
2 39 2
2014-05-27protein level
2 38 2
2014-02-25protein level
2 39 2
2013-12-09protein level
2 27 2
2013-11-01protein level
2 26 1
2013-09-12protein level
2 26 1
2013-08-17protein level
2 26 1
2013-07-15protein level
2 22 0
2013-06-11protein level
2 22 0
2013-02-12protein level
2 11 0
2012-12-20protein level
2 10 0
2012-10-30protein level
2 14 0
2012-10-07protein level
2 14 0
2012-08-24protein level
2 13 0
2012-07-28protein level
2 13 0
2012-06-08protein level
2 13 0
2012-05-07protein level
2 13 0
2012-04-10protein level
2 13 0
2012-01-13protein level
2 7 0
2011-12-20protein level
2 7 0
2011-11-11protein level
2 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43913-1
7 17 0 50251.0922
NX_O43913-2
1 17 0 37389.9786
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-374928,EBI-374889 ORC4  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.ATP binding
.DNA replication origin binding
.nucleotide binding
.actin cytoskeleton
.cytoplasm
.nucleolus
  + 4 more...
2 EBI-374928,EBI-374847 ORC1  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.ATP binding
.chromatin binding
.DNA binding
.plasma membrane
.cytosol
.cytoplasm
  + 5 more...
3 EBI-374928,EBI-374957 ORC2  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.DNA replication origin binding .membrane
.plasma membrane
.centrosome
  + 6 more...
4 EBI-374928,EBI-374916 ORC3  
  .neural precursor cell proliferation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.DNA replication origin binding .nuclear origin of replication recognition complex
.nucleoplasm
.origin recognition complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone27
brain23
cervix61
connective tissue33
embryonic tissue18
eye14
intestine25
kidney18
larynx42
liver14
lung26
lymph22
lymph node11
mammary gland6
muscle18
ovary9
pancreas14
pharynx24
pituitary gland60
placenta3
prostate26
testis87
thyroid21
uterus25
vascular19
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor17
germ cell tumor7
glioma37
head and neck tumor14
kidney tumor29
leukemia21
liver tumor31
lung tumor19
lymphoma55
non-neoplasia10
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer9
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult22
blastocyst16
fetus10
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.5
adrenal gland10.8
appendix9.3
bone marrow3.8
cerebral cortex8.7
colon11.4
duodenum8.4
esophagus11
gallbladder7.8
heart muscle5.3
kidney8.1
liver7.4
lung6.3
lymph node12
ovary10.3
pancreas7.5
placenta8.9
prostate16.4
salivary gland5.9
skin9.8
small intestine6.7
spleen7.8
stomach9.7
testis19.2
thyroid gland10.9
urinary bladder11.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602331, gene) Origin recognition complex, subunit 5, s. cerevisiae, homolog of;OMIM


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