Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O43914)
Protein (NX_O43914)
Protein
Gene SymbolTYROBP to neXtProt (NX_O43914)
DescriptionTYRO protein tyrosine kinase-binding protein
Chromosome19
Location19q13.12 (36395303 ~ 36399197) to Ensembl
Sequene Features : Isoforms 3, Variants 28, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of osteoclast development
.regulation of immune response
.innate immune response
  + 7 more...
.identical protein binding
.receptor binding
.receptor signaling protein activity
.cell surface
.integral component of plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 28 3
2014-09-19protein level
3 25 3
2014-05-27protein level
3 25 3
2014-02-25protein level
3 25 3
2013-12-09protein level
3 19 3
2013-11-01protein level
3 17 3
2013-09-12protein level
3 17 3
2013-08-17protein level
3 17 3
2013-07-15protein level
3 15 3
2013-06-11protein level
3 15 3
2013-02-12protein level
2 9 6
2012-12-20protein level
2 8 6
2012-10-30protein level
2 9 6
2012-10-07protein level
2 9 3
2012-08-24protein level
2 7 3
2012-07-28protein level
2 6 3
2012-06-08protein level
2 7 3
2012-05-07protein level
2 7 3
2012-04-10protein level
2 7 3
2012-01-13protein level
2 5 3
2011-12-20protein level
2 5 3
2011-11-11protein level
2 5 3
2011-08-23protein level
2 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43914-1
0 5 0 12171.3798
NX_O43914-2
0 4 0 12100.3429
NX_O43914-3
1 4 0 11035.7735
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2214794,EBI-2615458 SIRPB1  
  .innate immune response
.cell surface receptor signaling pathway
.signal transduction
.N/A .extracellular exosome
.integral component of plasma membrane
.plasma membrane
2 EBI-2214794,EBI-3862171 KLRC2  
  .innate immune response
.signal transduction
.cellular defense response
.natural killer cell mediated immunity
.protein antigen binding
.carbohydrate binding
.MHC class I protein complex binding
.transmembrane signaling receptor activity
.receptor complex
.integral component of plasma membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
blood89
bone41
bone marrow102
brain7
connective tissue26
ear124
eye14
heart44
intestine38
kidney56
larynx42
liver9
lung20
lymph node11
mammary gland72
mouth408
muscle37
ovary19
pancreas9
placenta31
prostate5
spleen74
testis13
thymus12
thyroid85
uterus56
Health State
TissuesTPM*
normal22
breast (mammary gland) tumor53
chondrosarcoma48
glioma37
head and neck tumor231
kidney tumor43
leukemia74
liver tumor20
non-neoplasia31
ovarian tumor26
pancreatic tumor19
prostate cancer9
soft tissue/muscle tissue tumor15
uterine tumor133
Developmental Stage
TissuesTPM*
adult54
neonate32
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue98.1
adrenal gland73.5
appendix195
bone marrow353.2
cerebral cortex28.2
colon56.7
duodenum64.6
esophagus29
gallbladder120
heart muscle31.7
kidney19.9
liver55.2
lung197.8
lymph node167.3
ovary17.6
pancreas11.4
placenta123.3
prostate18.6
salivary gland27.4
skin14.1
small intestine71.4
spleen278.3
stomach49.1
testis27
thyroid gland17.5
urinary bladder118.1
Tissues
TissuesExpression level
appendixLow
bone marrowHigh
cerebral cortexLow
gallbladderLow
hippocampusLow
lateral ventricleLow
lungHigh
lymph nodeMedium
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#221770, phenotype) Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy;OMIM
2(*604142, gene) Tyro protein tyrosine kinase-binding protein; TYROBPOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center