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> Protein (NX_O43933)
Protein (NX_O43933)
Protein
Gene SymbolPEX1 to neXtProt (NX_O43933)
DescriptionPeroxisome biogenesis factor 1
Chromosome7
Location7q21.2 (92116334 ~ 92157845) to Ensembl
Sequene Features : Isoforms 2, Variants 156, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.microtubule-based peroxisome localization
.protein import into peroxisome matrix
.metabolic process
  + 2 more...
.ATPase activity, coupled
.protein complex binding
.protein C-terminus binding
.ATP binding
.extracellular exosome
.intracellular membrane-bounded organelle
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 156 7
2014-09-19protein level
1 123 7
2014-05-27protein level
1 123 7
2014-02-25protein level
1 100 7
2013-12-09protein level
1 91 7
2013-11-01protein level
1 84 7
2013-09-12protein level
1 84 7
2013-08-17protein level
1 84 7
2013-07-15protein level
1 65 3
2013-06-11protein level
1 65 3
2013-02-12protein level
1 37 4
2012-12-20protein level
1 30 4
2012-10-30protein level
1 41 4
2012-10-07protein level
1 41 4
2012-08-24protein level
1 36 4
2012-07-28protein level
1 36 4
2012-06-08protein level
1 36 4
2012-05-07protein level
1 36 4
2012-04-10protein level
1 36 4
2012-01-13protein level
1 23 4
2011-12-20protein level
1 23 4
2011-11-11protein level
1 23 4
2011-08-23protein level
1 23 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43933-1
13 44 0 142777.2135
NX_O43933-2
1 44 0 105932.4446
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-988601,EBI-988581 PEX6  
  .protein stabilization
.protein import into peroxisome matrix, translocation
.metabolic process
  + 2 more...
.ATPase activity, coupled
.protein complex binding
.ATPase activity
  + 2 more...
.cytosol
.peroxisomal membrane
.peroxisome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder33
blood8
bone marrow41
brain24
cervix20
connective tissue20
embryonic tissue28
esophagus49
eye14
heart67
intestine12
kidney37
lung17
lymph node122
mammary gland92
mouth15
muscle9
ovary19
pancreas4
placenta7
prostate36
skin18
spleen18
stomach10
testis48
thymus50
thyroid21
trachea57
uterus34
Health State
TissuesTPM*
normal27
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma24
colorectal tumor17
esophageal tumor57
gastrointestinal tumor16
germ cell tumor26
head and neck tumor14
kidney tumor58
leukemia21
lung tumor19
lymphoma13
non-neoplasia10
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer57
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult31
embryoid body14
blastocyst16
neonate32
fetus44
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.5
adrenal gland13
appendix13.6
bone marrow6.3
cerebral cortex12.5
colon14.2
duodenum15
esophagus11.7
gallbladder9.9
heart muscle12.3
kidney16.4
liver8.2
lung12.5
lymph node16.6
ovary15.9
pancreas7.9
placenta8.2
prostate14.5
salivary gland13
skin21.1
small intestine14.6
spleen15.2
stomach13.2
testis13.1
thyroid gland17.5
urinary bladder11.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#214100, phenotype) Peroxisome biogenesis disorder 1a (zellweger); PBD1AOMIM
2(#601539, phenotype) Peroxisome biogenesis disorder 1b; PBD1BOMIM
3(*602136, gene) Peroxisome biogenesis factor 1; PEX1OMIM


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