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> Protein (NX_O60238)
Protein (NX_O60238)
Protein
Gene SymbolBNIP3L to neXtProt (NX_O60238)
DescriptionBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Chromosome8
Location8p21.2 (26240414 ~ 26363152) to Ensembl
Sequene Features : Isoforms 2, Variants 13, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitochondrial outer membrane permeabilization
.defense response to virus
.negative regulation of apoptotic process
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.lamin binding
.intrinsic component of membrane
.integral component of membrane
.endoplasmic reticulum
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 13 6
2014-09-19protein level
1 9 6
2014-05-27protein level
1 9 7
2014-02-25protein level
1 9 7
2013-12-09protein level
1 6 7
2013-11-01protein level
1 5 6
2013-09-12protein level
1 5 7
2013-08-17protein level
1 5 7
2013-07-15protein level
1 4 6
2013-06-11protein level
1 4 6
2013-02-12protein level
1 3 5
2012-12-20protein level
1 3 5
2012-10-30protein level
1 3 5
2012-10-07protein level
1 3 5
2012-08-24protein level
1 3 5
2012-07-28protein level
1 3 5
2012-06-08protein level
1 5 5
2012-05-07protein level
1 8 5
2012-04-10protein level
1 8 5
2012-01-13protein level
1 5 5
2011-12-20protein level
1 5 5
2011-11-11protein level
1 5 5
2011-08-23protein level
1 5 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60238-1
1 7 1 23915.415
NX_O60238-2
1 7 1 19546.4101
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-849893,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
2 EBI-849893,EBI-723946 TMEM11  
  .mitochondrion organization .N/A .integral component of mitochondrial inner membrane
.integral component of plasma membrane
3 EBI-849893,EBI-749464 BNIP3  
  .intrinsic apoptotic signaling pathway in response to hypoxia
.toxin transport
.mitochondrial outer membrane permeabilization
  + 28 more...
.GTPase binding
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.mitochondrial membrane
.integral component of mitochondrial outer membrane
.dendrite
  + 7 more...
4 EBI-849893,EBI-10173166 LDLRAD1  
  .N/A .N/A .integral component of membrane
5 EBI-849893,EBI-700771 BAD  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
6 EBI-849893,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
7 EBI-849893,EBI-3939278 CLEC7A  
  .innate immune response
.defense response to protozoan
.T cell activation
  + 6 more...
.metal ion binding
.MHC protein binding
.carbohydrate binding
.signaling pattern recognition receptor activity
.integral component of membrane
.plasma membrane
.cytoplasm
8 EBI-849893,EBI-6308763 ATP13A2  
  .cellular response to manganese ion
.metabolic process
.cation transport
.metal ion binding
.ATPase activity
.ATP binding
.integral component of membrane
.lysosomal membrane
.lysosome
9 EBI-849893,EBI-8640191 SMCO4  
  .N/A .N/A .integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites25
bladder133
blood1235
bone223
bone marrow287
brain182
cervix41
connective tissue114
ear186
embryonic tissue140
esophagus49
eye134
heart89
intestine60
kidney113
larynx42
liver141
lung86
lymph22
lymph node100
mammary gland119
mouth90
muscle197
nerve64
ovary59
pancreas117
parathyroid194
pharynx171
pituitary gland121
placenta109
prostate26
salivary gland49
skin99
spleen18
stomach10
testis197
thymus87
trachea115
umbilical cord145
uterus99
vascular154
Health State
TissuesTPM*
normal186
bladder carcinoma227
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma229
colorectal tumor71
esophageal tumor57
gastrointestinal tumor16
germ cell tumor75
glioma102
head and neck tumor52
kidney tumor29
leukemia137
liver tumor83
lung tumor19
lymphoma41
non-neoplasia113
ovarian tumor65
pancreatic tumor133
primitive neuroectodermal tumor of the CNS78
prostate cancer9
retinoblastoma86
skin tumor95
soft tissue/muscle tissue tumor95
uterine tumor133
Developmental Stage
TissuesTPM*
adult100
embryoid body171
blastocyst48
neonate128
fetus156
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue101
adrenal gland53.6
appendix37
bone marrow101.1
cerebral cortex63.9
colon26.5
duodenum19.5
esophagus44.3
gallbladder56.8
heart muscle43
kidney55.2
liver26.1
lung51.8
lymph node37.3
ovary108.6
pancreas11.2
placenta87.3
prostate38.9
salivary gland31.8
skin51.5
small intestine26
spleen36.1
stomach25.5
testis67.5
thyroid gland41.4
urinary bladder53.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605368, gene) Bcl2/adenovirus e1b 19-kd protein-interacting protein 3-like; BNIP3LOMIM


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