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> Protein (NX_O60264)
Protein (NX_O60264)
Protein
Gene SymbolSMARCA5 to neXtProt (NX_O60264)
DescriptionSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Chromosome4
Location4q31.21 (144434616 ~ 144478639) to Ensembl
Sequene Features : Isoforms 1, Variants 84, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of gene expression, epigenetic
.ATP-dependent chromatin remodeling
.regulation of gene expression, epigenetic
  + 9 more...
.ATPase activity
.ATP binding
.helicase activity
  + 2 more...
.RSF complex
.NURF complex
.nucleolus
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 84 17
2014-09-19protein level
1 61 17
2014-05-27protein level
1 61 20
2014-02-25protein level
1 61 20
2013-12-09protein level
1 54 20
2013-11-01protein level
1 53 11
2013-09-12protein level
1 53 11
2013-08-17protein level
1 53 11
2013-07-15protein level
1 25 8
2013-06-11protein level
1 25 8
2013-02-12protein level
1 9 9
2012-12-20protein level
1 9 9
2012-10-30protein level
1 9 9
2012-10-07protein level
1 9 9
2012-08-24protein level
1 8 9
2012-07-28protein level
1 8 9
2012-06-08protein level
1 10 9
2012-05-07protein level
1 3 9
2012-04-10protein level
1 3 9
2012-01-13protein level
1 5 9
2011-12-20protein level
1 5 9
2011-11-11protein level
1 5 9
2011-08-23protein level
1 5 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60264-1
37 0 11 121828.0118
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352588,EBI-302023 HIST2H4A  
  .protein heterotetramerization
.negative regulation of gene expression, epigenetic
.negative regulation of megakaryocyte differentiation
  + 13 more...
.poly(A) RNA binding
.histone binding
.histone demethylase activity (H4-K20 specific)
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 5 more...
2 EBI-352588,EBI-926768 RSF1  
  .positive regulation of viral transcription
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 6 more...
.histone binding
.zinc ion binding
.RSF complex
.nucleoplasm
.nucleus
3 EBI-352588,EBI-927482 BAZ1B  
  .chromatin-mediated maintenance of transcription
.peptidyl-tyrosine phosphorylation
.histone phosphorylation
  + 6 more...
.vitamin D receptor activator activity
.lysine-acetylated histone binding
.histone kinase activity
  + 5 more...
.pericentric heterochromatin
.nucleus
.condensed chromosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland121
ascites50
bladder133
blood32
bone83
bone marrow123
brain59
cervix20
connective tissue60
ear310
embryonic tissue197
esophagus49
eye76
heart78
intestine56
kidney61
larynx42
liver48
lung62
lymph22
lymph node211
mammary gland85
mouth136
muscle9
nerve128
ovary9
pancreas70
parathyroid97
pharynx24
pituitary gland60
placenta70
prostate63
salivary gland98
skin66
spleen37
stomach10
testis174
thymus75
thyroid42
trachea154
uterus103
vascular96
Health State
TissuesTPM*
normal83
adrenal tumor237
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma84
colorectal tumor79
esophageal tumor57
gastrointestinal tumor59
germ cell tumor140
glioma27
head and neck tumor74
kidney tumor29
leukemia42
liver tumor83
lung tumor19
lymphoma55
non-neoplasia41
ovarian tumor13
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
prostate cancer48
retinoblastoma64
skin tumor95
soft tissue/muscle tissue tumor87
uterine tumor55
Developmental Stage
TissuesTPM*
adult80
embryoid body214
blastocyst244
fetus71
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.6
adrenal gland32.1
appendix22.3
bone marrow21.8
cerebral cortex26.5
colon22.9
duodenum14.4
esophagus14.4
gallbladder21.5
heart muscle13.7
kidney17.9
liver12.8
lung26.2
lymph node26.7
ovary22
pancreas8.8
placenta20.6
prostate20.1
salivary gland8.6
skin9.9
small intestine18.8
spleen24.7
stomach17.9
testis34
thyroid gland23.9
urinary bladder24.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603375, gene) Swi/snf-related, matrix-associated, actin-dependent regulator of chromatin,OMIM


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