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> Protein (NX_O60285)
Protein (NX_O60285)
Protein
Gene SymbolNUAK1 to neXtProt (NX_O60285)
DescriptionNUAK family SNF1-like kinase 1
Chromosome12
Location12q23.3 (106457118 ~ 106533811) to Ensembl
Sequene Features : Isoforms 2, Variants 115, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular senescence
.cellular response to glucose starvation
.regulation of cell proliferation
  + 6 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.p53 binding
.AMP-activated protein kinase complex
.microtubule cytoskeleton
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 115 7
2014-09-19protein level
2 90 7
2014-05-27protein level
2 90 9
2014-02-25protein level
2 89 9
2013-12-09protein level
2 78 9
2013-11-01protein level
2 70 9
2013-09-12protein level
2 70 9
2013-08-17protein level
2 70 9
2013-07-15protein level
2 40 9
2013-06-11protein level
2 40 9
2013-02-12protein level
2 17 13
2012-12-20protein level
2 17 13
2012-10-30protein level
2 18 13
2012-10-07protein level
2 18 12
2012-08-24protein level
2 11 12
2012-07-28protein level
2 11 12
2012-06-08protein level
2 7 12
2012-05-07protein level
2 7 12
2012-04-10protein level
2 7 12
2012-01-13protein level
2 7 12
2011-12-20protein level
2 9 12
2011-11-11protein level
2 9 12
2011-08-23protein level
2 7 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60285-1
22 8 0 74258.5936
NX_O60285-2
1 8 0 23809.4419
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1046789,EBI-444209 LATS1  
  .negative regulation of canonical Wnt signaling pathway
.cell division
.cytoplasmic sequestering of protein
  + 11 more...
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.microtubule organizing center
.spindle pole
2 EBI-1046789,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
bone13
brain55
connective tissue40
embryonic tissue32
eye14
heart11
intestine21
kidney9
larynx127
liver34
lung20
mammary gland13
ovary19
pancreas9
pharynx24
placenta3
prostate31
skin4
testis11
umbilical cord72
uterus8
vascular38
Health State
TissuesTPM*
normal31
breast (mammary gland) tumor10
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor8
germ cell tumor18
glioma18
head and neck tumor22
liver tumor41
lung tumor9
non-neoplasia62
pancreatic tumor19
prostate cancer9
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult18
embryoid body28
blastocyst65
neonate32
fetus44
infant297
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.6
adrenal gland3.6
appendix2.7
cerebral cortex25.2
colon3.2
duodenum2.1
esophagus3.2
gallbladder4.6
heart muscle13
kidney3.7
liver1.5
lung7.4
lymph node2.9
ovary4.4
placenta4.7
prostate5.4
salivary gland1.9
skin14.5
small intestine1.6
stomach2.3
testis3
thyroid gland3.5
urinary bladder6.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608130, gene) Nuak family, snf1-like kinase, 1; NUAK1OMIM


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