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> Protein (NX_O60291)
Protein (NX_O60291)
Protein
Gene SymbolMGRN1 to neXtProt (NX_O60291)
DescriptionE3 ubiquitin-protein ligase MGRN1
Chromosome16
Location16p13.3 (4666494 ~ 4740975) to Ensembl
Sequene Features : Isoforms 4, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of G-protein coupled receptor protein signaling pathway
.negative regulation of cAMP-mediated signaling
.endosome to lysosome transport
  + 2 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.extracellular exosome
.membrane
.plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 58 7
2014-09-19protein level
4 43 7
2014-05-27protein level
4 43 7
2014-02-25protein level
4 42 7
2013-12-09protein level
4 26 7
2013-11-01protein level
4 26 6
2013-09-12protein level
4 26 5
2013-08-17protein level
4 26 5
2013-07-15protein level
4 17 4
2013-06-11protein level
4 17 4
2013-02-12protein level
4 8 8
2012-12-20protein level
4 8 8
2012-10-30protein level
4 7 8
2012-10-07protein level
4 7 2
2012-08-24protein level
4 6 2
2012-07-28protein level
4 6 2
2012-06-08protein level
4 10 2
2012-05-07protein level
4 4 2
2012-04-10protein level
4 4 2
2012-01-13protein level
4 6 2
2011-12-20protein level
4 6 2
2011-11-11protein level
4 6 2
2011-08-23protein level
4 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60291-1
0 23 2 60714.9706
NX_O60291-2
0 23 2 63150.2234
NX_O60291-3
0 21 2 60703.8677
NX_O60291-4
0 21 2 58268.6149
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2129851,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood24
bone13
bone marrow61
brain48
connective tissue33
embryonic tissue84
eye81
heart11
intestine47
kidney52
larynx42
liver43
lung68
lymph22
lymph node22
mammary gland92
mouth15
nerve128
ovary9
pancreas79
placenta38
prostate10
salivary gland296
skin56
spleen37
stomach10
testis71
thymus12
thyroid21
trachea19
uterus30
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor85
chondrosarcoma84
colorectal tumor53
germ cell tumor45
glioma65
head and neck tumor67
kidney tumor130
leukemia21
liver tumor72
lung tumor107
lymphoma13
non-neoplasia10
pancreatic tumor104
primitive neuroectodermal tumor of the CNS39
prostate cancer9
retinoblastoma86
skin tumor71
soft tissue/muscle tissue tumor39
uterine tumor11
Developmental Stage
TissuesTPM*
adult45
embryoid body114
blastocyst81
fetus25
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.7
adrenal gland18.2
appendix20.6
bone marrow21.2
cerebral cortex27.3
colon15.9
duodenum22.8
esophagus12.1
gallbladder20.9
heart muscle15.3
kidney18.4
liver14.5
lung21.9
lymph node15.8
ovary18.7
pancreas15.7
placenta20
prostate21.2
salivary gland17
skin10.1
small intestine22.7
spleen28.7
stomach24.5
testis15.4
thyroid gland19.5
urinary bladder19.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607559, gene) Mahogunin, ring finger 1; MGRN1OMIM


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