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> Protein (NX_O60331)
Protein (NX_O60331)
Protein
Gene SymbolPIP5K1C to neXtProt (NX_O60331)
DescriptionPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Chromosome19
Location19p13.3 (3630181 ~ 3700477) to Ensembl
Sequene Features : Isoforms 4, Variants 90, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.clathrin-mediated endocytosis
.platelet aggregation
.synaptic vesicle endocytosis
  + 11 more...
.1-phosphatidylinositol-4-phosphate 5-kinase activity
.ATP binding
.ruffle membrane
.endomembrane system
.focal adhesion
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 90 7
2014-09-19protein level
4 63 7
2014-05-27protein level
4 63 7
2014-02-25protein level
4 61 7
2013-12-09protein level
4 49 7
2013-11-01protein level
4 47 7
2013-09-12protein level
4 47 7
2013-08-17protein level
4 47 7
2013-07-15protein level
4 30 7
2013-06-11protein level
4 30 7
2013-02-12protein level
4 19 22
2012-12-20protein level
4 20 22
2012-10-30protein level
4 21 22
2012-10-07protein level
4 21 7
2012-08-24protein level
4 13 7
2012-07-28protein level
4 13 7
2012-06-08protein level
4 4 7
2012-05-07protein level
4 4 7
2012-04-10protein level
4 4 7
2012-01-13protein level
4 4 7
2011-12-20protein level
4 13 7
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60331-1
2 22 2 73214.285
NX_O60331-2
3 22 2 76571.9326
NX_O60331-3
3 22 2 77435.643
NX_O60331-4
1 22 2 70169.9506
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8838062,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder66
blood8
bone69
brain29
cervix41
connective tissue6
embryonic tissue37
eye90
heart33
intestine38
kidney28
lung38
lymph45
lymph node33
mammary gland46
muscle9
nerve128
ovary19
pancreas23
placenta24
prostate52
salivary gland98
skin33
spleen18
stomach31
testis66
thyroid64
uterus17
vascular38
Health State
TissuesTPM*
normal34
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor42
germ cell tumor30
glioma83
head and neck tumor29
kidney tumor58
leukemia31
lung tumor19
lymphoma27
non-neoplasia20
ovarian tumor13
pancreatic tumor47
prostate cancer57
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult40
embryoid body57
blastocyst32
fetus32
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.4
adrenal gland7.1
appendix9.9
bone marrow2.3
cerebral cortex27.6
colon9.1
duodenum6.9
esophagus14.4
gallbladder10.8
heart muscle11.4
kidney8.6
liver1.9
lung10.9
lymph node6.7
ovary8.3
pancreas7.4
placenta10.6
prostate16.1
salivary gland12.6
skin7.1
small intestine7.7
spleen15
stomach9.7
testis28.1
thyroid gland10.8
urinary bladder15.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606102, gene) Phosphatidylinositol 4-phosphate 5-kinase, type i, gamma; PIP5K1COMIM
2(#611369, phenotype) Lethal congenital contractural syndrome 3; LCCS3OMIM


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