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> Protein (NX_O60336)
Protein (NX_O60336)
Protein
Gene SymbolMAPKBP1 to neXtProt (NX_O60336)
DescriptionMitogen-activated protein kinase-binding protein 1
Chromosome15
Location15q15.1 (42066632 ~ 42120053) to Ensembl
Sequene Features : Isoforms 6, Variants 163, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 163 3
2014-09-19protein level
6 130 3
2014-05-27protein level
6 130 3
2014-02-25protein level
6 129 3
2013-12-09protein level
6 104 3
2013-11-01protein level
6 99 3
2013-09-12protein level
6 99 2
2013-08-17protein level
6 99 2
2013-07-15protein level
6 81 2
2013-06-11protein level
6 81 2
2013-02-12transcript level
6 52 0
2012-12-20transcript level
6 51 0
2012-10-30transcript level
6 58 0
2012-10-07transcript level
6 58 0
2012-08-24transcript level
6 56 0
2012-07-28transcript level
6 56 0
2012-06-08transcript level
6 58 0
2012-05-07transcript level
6 43 0
2012-04-10transcript level
6 43 0
2012-01-13transcript level
6 15 0
2011-12-20transcript level
6 15 0
2011-11-11transcript level
6 15 0
2011-08-23transcript level
6 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60336-1
1 70 0 163715.7575
NX_O60336-2
1 58 0 134224.8625
NX_O60336-3
1 65 0 149851.0735
NX_O60336-4
0 44 0 109087.1503
NX_O60336-5
0 12 0 23692.2898
NX_O60336-6
0 71 0 163038.4572
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-947402,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-947402,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
3 EBI-947402,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
4 EBI-947402,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
5 EBI-947402,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
6 EBI-947402,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
7 EBI-947402,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
8 EBI-947402,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
9 EBI-947402,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
10 EBI-947402,EBI-751001 KEAP1  
  .cellular response to interleukin-4
.regulation of epidermal cell differentiation
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.transcription factor binding .Cul3-RING ubiquitin ligase complex
.midbody
.cytosol
  + 4 more...
11 EBI-947402,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
12 EBI-947402,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
13 EBI-947402,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
14 EBI-947402,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
15 EBI-947402,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
16 EBI-947402,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
17 EBI-947402,EBI-742397 TEX11  
  .chiasma assembly
.negative regulation of apoptotic process
.fertilization
  + 6 more...
.N/A .central element
18 EBI-947402,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
19 EBI-947402,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
20 EBI-947402,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
21 EBI-947402,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
22 EBI-947402,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
23 EBI-947402,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
24 EBI-947402,EBI-10186621 ALG13  
  .cellular protein metabolic process
.post-translational protein modification
.lipid glycosylation
  + 2 more...
.poly(A) RNA binding
.carbohydrate binding
.cysteine-type peptidase activity
.N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
.endoplasmic reticulum membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood16
bone55
brain41
embryonic tissue18
eye23
heart11
kidney4
liver4
lung23
lymph22
lymph node22
mouth30
muscle28
pancreas37
parathyroid48
pharynx24
pituitary gland60
placenta35
skin33
stomach10
testis98
thymus37
thyroid85
trachea38
uterus43
vascular77
Health State
TissuesTPM*
normal29
bladder carcinoma170
chondrosarcoma48
gastrointestinal tumor8
germ cell tumor3
glioma46
head and neck tumor44
lung tumor38
lymphoma13
non-neoplasia31
primitive neuroectodermal tumor of the CNS15
skin tumor39
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult32
embryoid body14
blastocyst32
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.9
adrenal gland8.9
appendix7.7
bone marrow5.7
cerebral cortex11.5
colon4.2
duodenum13.5
esophagus15.1
gallbladder7.8
heart muscle4.4
kidney4.2
liver1.2
lung7.4
lymph node6
ovary15.9
pancreas3.2
placenta7.6
prostate7.1
salivary gland4.5
skin30.5
small intestine13.5
spleen9.6
stomach5
testis35
thyroid gland11.8
urinary bladder7.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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2014-2019 (C) Yonsei Proteome Research Center