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> Protein (NX_O60341)
Protein (NX_O60341)
Protein
Gene SymbolKDM1A to neXtProt (NX_O60341)
DescriptionLysine-specific histone demethylase 1A
Chromosome1
Location1p36.12 (23345941 ~ 23410182) to Ensembl
Sequene Features : Isoforms 2, Variants 46, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 46 16
2014-09-19protein level
2 33 16
2014-05-27protein level
2 33 16
2014-02-25protein level
2 33 16
2013-12-09protein level
2 31 16
2013-11-01protein level
2 30 16
2013-09-12protein level
2 30 16
2013-08-17protein level
2 30 16
2013-07-15protein level
2 19 7
2013-06-11protein level
2 19 7
2013-02-12protein level
2 9 14
2012-12-20protein level
2 8 14
2012-10-30protein level
2 9 14
2012-10-07protein level
2 9 7
2012-08-24protein level
2 8 7
2012-07-28protein level
2 8 7
2012-06-08protein level
2 16 7
2012-05-07protein level
2 9 7
2012-04-10protein level
2 9 7
2012-01-13protein level
2 12 7
2011-12-20protein level
2 12 7
2011-11-11protein level
2 12 7
2011-08-23protein level
2 12 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60341-1
2 35 0 92844.3997
NX_O60341-2
2 35 0 95095.3561
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-710124,EBI-8466445 CCDC151  
  .regulation of cilium assembly
.cell projection organization
.cilium movement
.N/A .ciliary basal body
.axoneme
.cilium
.centriole
2 EBI-710124,EBI-748763 SMAD9  
  .cellular response to organic cyclic compound
.bone development
.cartilage development
  + 12 more...
.metal ion binding
.transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytosol
.cytoplasm
.transcription factor complex
  + 3 more...
3 EBI-710124,EBI-607682 HDAC3  
  .cellular response to fluid shear stress
.spindle assembly
.neurotrophin TRK receptor signaling pathway
  + 21 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.transcriptional repressor complex
.plasma membrane
.spindle microtubule
  + 5 more...
4 EBI-710124,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
5 EBI-710124,EBI-1783068 MBD3  
  .ATP-dependent chromatin remodeling
.histone acetylation
.tissue development
  + 5 more...
.methyl-CpG binding
.chromatin binding
.DNA binding
.protein complex
.NuRD complex
.cytoplasm
  + 3 more...
6 EBI-710124,EBI-960081 RASSF2  
  .negative regulation of NIK/NF-kappaB signaling
.homeostasis of number of cells
.bone remodeling
  + 6 more...
.N/A .cytoplasm
.nucleus
7 EBI-710124,EBI-357598 PSMC1  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.poly(A) RNA binding
.proteasome-activating ATPase activity
.TBP-class protein binding
  + 2 more...
.cytosolic proteasome complex
.nuclear proteasome complex
.cell junction
  + 8 more...
8 EBI-710124,EBI-6426768 PPARD  
  .apoptotic signaling pathway
.cellular response to hypoxia
.adipose tissue development
  + 46 more...
.linoleic acid binding
.sequence-specific DNA binding
.lipid binding
  + 7 more...
.nucleoplasm
.nucleus
9 EBI-710124,EBI-523590 CHD3  
  .centrosome organization
.DNA duplex unwinding
.chromatin modification
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.ATP binding
  + 3 more...
.intermediate filament cytoskeleton
.NuRD complex
.centrosome
  + 4 more...
10 EBI-710124,EBI-781356 NR1H3  
  .positive regulation of cholesterol homeostasis
.regulation of cholesterol homeostasis
.negative regulation of secretion of lysosomal enzymes
  + 30 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.sterol response element binding
  + 6 more...
.RNA polymerase II transcription factor complex
.receptor complex
.nucleoplasm
  + 2 more...
11 EBI-710124,EBI-749111 SF3B2  
  .viral process
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
12 EBI-710124,EBI-358900 HIST3H3  
  .protein heterotetramerization
.negative regulation of protein oligomerization
.nucleosome assembly
.telomere maintenance
.histone binding
.DNA binding
.extracellular exosome
.nucleoplasm
.nucleus
  + 2 more...
13 EBI-710124,EBI-473801 IMMT  
  .mitochondrial calcium ion homeostasis
.response to cold
.poly(A) RNA binding .integral component of membrane
.membrane
.mitochondrial inner membrane
.mitochondrion
14 EBI-710124,EBI-2339674 PHF19  
  .positive regulation of histone H3-K27 methylation
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 4 more...
.methylated histone binding
.zinc ion binding
.nucleoplasm
15 EBI-710124,EBI-8466055 C8orf74  
  .N/A .N/A .N/A
16 EBI-710124,EBI-1646500 ASXL1  
  .bone development
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of retinoic acid receptor signaling pathway
  + 7 more...
.metal ion binding
.peroxisome proliferator activated receptor binding
.retinoic acid receptor binding
  + 3 more...
.extracellular exosome
.PR-DUB complex
.nuclear chromatin
17 EBI-710124,EBI-716449 PELP1  
  .cellular response to estrogen stimulus
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.poly(A) RNA binding
.transcription factor binding
.chromatin binding
.MLL1 complex
.transcriptionally active chromatin
.membrane
  + 4 more...
18 EBI-710124,EBI-8477661 OFCC1  
  .N/A .N/A .N/A
19 EBI-710124,EBI-8468186 FAM9A  
  .spermatid development .N/A .nucleolus
.nucleus
20 EBI-710124,EBI-8484990 STX19  
  .vesicle docking
.synaptic vesicle fusion to presynaptic membrane
.intracellular protein transport
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 2 more...
21 EBI-710124,EBI-748741 SAMD3  
  .N/A .N/A .N/A
22 EBI-710124,EBI-8469616 GSTCD  
  .N/A .N/A .extracellular exosome
.cytoplasm
23 EBI-710124,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
24 EBI-710124,EBI-8472352 KLHDC4  
  .N/A .N/A .N/A
25 EBI-710124,EBI-2659201 SPSB1  
  .intracellular signal transduction
.protein ubiquitination
.N/A .cytoplasm
26 EBI-710124,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
27 EBI-710124,EBI-356767 DNAJA3  
  .skeletal muscle acetylcholine-gated channel clustering
.negative regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 23 more...
.chaperone binding
.unfolded protein binding
.NF-kappaB binding
  + 5 more...
.postsynaptic membrane
.intracellular membrane-bounded organelle
.mitochondrial nucleoid
  + 8 more...
28 EBI-710124,EBI-747719 SNF8  
  .regulation of viral budding via host ESCRT complex
.positive regulation of exosomal secretion
.regulation of protein complex stability
  + 11 more...
.protein N-terminus binding
.protein homodimerization activity
.channel regulator activity
  + 2 more...
.extracellular exosome
.recycling endosome
.perinuclear region of cytoplasm
  + 10 more...
29 EBI-710124,EBI-749562 LOXL4  
  .N/A .copper ion binding
.scavenger receptor activity
.protein-lysine 6-oxidase activity
.extracellular exosome
.receptor complex
.membrane
.extracellular space
30 EBI-710124,EBI-1048311 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
31 EBI-710124,EBI-2869338 FYCO1  
  .plus-end-directed vesicle transport along microtubule .metal ion binding .cytoplasmic vesicle
.integral component of membrane
.membrane
  + 3 more...
32 EBI-710124,EBI-6115579 GTPBP2  
  .N/A .GTP binding
.GTPase activity
.intracellular membrane-bounded organelle
33 EBI-710124,EBI-1773949 CDCA4  
  .N/A .N/A .nucleus
34 EBI-710124,EBI-367363 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
35 EBI-710124,EBI-8470369 HESX1  
  .forebrain morphogenesis
.negative regulation of transcription, DNA-templated
.nose development
  + 3 more...
.sequence-specific DNA binding
.chromatin binding
.DNA binding
.nucleus
36 EBI-710124,EBI-465368 SERGEF  
  .negative regulation of protein secretion
.positive regulation of GTPase activity
.signal transduction
.Ran guanyl-nucleotide exchange factor activity .intermediate filament cytoskeleton
.cytoplasm
.nucleolus
.nucleus
37 EBI-710124,EBI-926563 RCOR1  
  .histone H4 deacetylation
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.transcription regulatory region DNA binding
.chromatin binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.transcriptional repressor complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites150
bladder167
blood24
bone41
bone marrow41
brain45
cervix103
connective tissue33
embryonic tissue253
esophagus99
eye119
heart55
intestine68
kidney33
larynx42
liver34
lung50
lymph45
lymph node44
mammary gland204
mouth75
muscle18
nerve64
ovary68
pancreas23
parathyroid145
pharynx73
pituitary gland121
placenta45
prostate100
salivary gland98
skin52
stomach94
testis181
thymus25
thyroid128
tonsil117
uterus124
Health State
TissuesTPM*
normal69
adrenal tumor237
bladder carcinoma341
breast (mammary gland) tumor85
cervical tumor86
chondrosarcoma60
colorectal tumor71
esophageal tumor115
gastrointestinal tumor151
germ cell tumor121
glioma93
head and neck tumor104
kidney tumor72
leukemia21
liver tumor62
lung tumor77
lymphoma27
non-neoplasia82
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS55
prostate cancer182
retinoblastoma258
skin tumor47
soft tissue/muscle tissue tumor151
uterine tumor77
Developmental Stage
TissuesTPM*
adult86
embryoid body300
blastocyst292
fetus71
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17
adrenal gland25.9
appendix24
bone marrow27.5
cerebral cortex20.3
colon27.7
duodenum23.8
esophagus24.6
gallbladder24.7
heart muscle17.5
kidney21
liver10.5
lung22.6
lymph node32.2
ovary38.4
pancreas11.9
placenta25.8
prostate28
salivary gland19.5
skin29.5
small intestine24.2
spleen21.6
stomach20.5
testis86.7
thyroid gland27.5
urinary bladder31.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxLow
oral mucosaLow
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaHigh
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1High
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1Medium
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609132, gene) Lysine-specific demethylase 1a; KDM1AOMIM


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