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> Protein (NX_O60346)
Protein (NX_O60346)
Protein
Gene SymbolPHLPP1 to neXtProt (NX_O60346)
DescriptionPH domain leucine-rich repeat-containing protein phosphatase 1
Chromosome18
Location18q21.33 (60382672 ~ 60647666) to Ensembl
Sequene Features : Isoforms 1, Variants 116, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.innate immune response
  + 5 more...
.metal ion binding
.phosphoprotein phosphatase activity
.membrane
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 116 4
2014-09-19protein level
1 101 4
2014-05-27protein level
1 101 4
2014-02-25protein level
1 97 4
2013-12-09protein level
1 75 4
2013-11-01protein level
1 74 2
2013-09-12protein level
1 74 1
2013-08-17protein level
1 74 1
2013-07-15protein level
1 36 1
2013-06-11protein level
1 36 1
2013-02-12protein level
1 19 1
2012-12-20protein level
1 21 1
2012-10-30protein level
1 30 1
2012-10-07protein level
1 30 1
2012-08-24protein level
1 29 1
2012-07-28protein level
1 29 1
2012-06-08protein level
1 36 1
2012-05-07protein level
1 31 1
2012-04-10protein level
1 31 1
2012-01-13protein level
1 22 1
2011-12-20protein level
1 22 1
2011-11-11protein level
1 22 1
2011-08-23protein level
1 22 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60346-1
80 0 0 184555.9505
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2511516,EBI-5774511 PRKCB  
  .cellular response to carbohydrate stimulus
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of B cell receptor signaling pathway
  + 24 more...
.androgen receptor binding
.histone binding
.histone kinase activity (H3-T6 specific)
  + 8 more...
.extracellular exosome
.membrane
.plasma membrane
  + 4 more...
2 EBI-2511516,EBI-357345 SCRIB  
  .activation of GTPase activity
.protein localization to adherens junction
.mammary gland duct morphogenesis
  + 18 more...
.N/A .extracellular exosome
.myelin sheath abaxonal region
.Scrib-APC-beta-catenin complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone41
bone marrow41
brain46
cervix20
ear62
embryonic tissue32
eye90
intestine8
kidney9
liver14
lung17
lymph22
lymph node55
mammary gland6
mouth60
muscle28
nerve64
ovary9
pancreas4
parathyroid48
placenta24
prostate26
skin47
spleen18
testis22
thyroid21
uterus17
Health State
TissuesTPM*
normal38
gastrointestinal tumor8
germ cell tumor26
glioma27
head and neck tumor29
leukemia63
liver tumor10
lymphoma13
non-neoplasia10
ovarian tumor13
pancreatic tumor9
prostate cancer38
retinoblastoma107
skin tumor71
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult25
embryoid body28
blastocyst65
fetus57
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.5
adrenal gland10.4
appendix2.3
bone marrow5.7
cerebral cortex28
colon5.8
duodenum4.8
esophagus5.9
gallbladder5.6
heart muscle2.5
kidney3.4
liver12.8
lung3.3
lymph node2.9
ovary4.9
pancreas3.9
placenta7.7
prostate3.7
salivary gland8.1
skin7.3
small intestine4.7
spleen1.9
stomach4.9
testis13.6
thyroid gland5.1
urinary bladder6.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609396, gene) Ph domain and leucine-rich repeat protein phosphatase; PHLPPOMIM


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