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> Protein (NX_O60437)
Protein (NX_O60437)
Protein
Gene SymbolPPL to neXtProt (NX_O60437)
DescriptionPeriplakin
Chromosome16
Location16p13.3 (4932508 ~ 5010742) to Ensembl
Sequene Features : Isoforms 1, Variants 299, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 299 5
2014-09-19protein level
1 249 5
2014-05-27protein level
1 249 5
2014-02-25protein level
1 246 5
2013-12-09protein level
1 172 5
2013-11-01protein level
1 166 5
2013-09-12protein level
1 166 5
2013-08-17protein level
1 166 5
2013-07-15protein level
1 134 5
2013-06-11protein level
1 134 5
2013-02-12protein level
1 94 6
2012-12-20protein level
1 89 6
2012-10-30protein level
1 109 6
2012-10-07protein level
1 109 6
2012-08-24protein level
1 98 6
2012-07-28protein level
1 97 6
2012-06-08protein level
1 100 6
2012-05-07protein level
1 100 6
2012-04-10protein level
1 100 6
2012-01-13protein level
1 41 6
2011-12-20protein level
1 41 6
2011-11-11protein level
1 41 5
2011-08-23protein level
1 41 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60437-1
95 0 0 204622.4269
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-368321,EBI-2371423 AHCYL1  
  .response to calcium ion
.regulation of anion transport
.S-adenosylmethionine cycle
  + 6 more...
.hydrolase activity .extracellular exosome
.cytosol
.endoplasmic reticulum
2 EBI-368321,EBI-720960 ANXA9  
  .single organismal cell-cell adhesion
.synaptic transmission
.protein homodimerization activity
.acetylcholine receptor activity
.calcium-dependent phospholipid binding
  + 3 more...
.extracellular exosome
.cell surface
.cytosol
3 EBI-368321,EBI-353844 VIM  
  .lens fiber cell development
.SMAD protein signal transduction
.Bergmann glial cell differentiation
  + 10 more...
.keratin filament binding
.scaffold protein binding
.identical protein binding
  + 5 more...
.extracellular exosome
.intermediate filament cytoskeleton
.neuron projection
  + 8 more...
4 EBI-368321,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
5 EBI-368321,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
6 EBI-368321,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
7 EBI-368321,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
8 EBI-368321,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
9 EBI-368321,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
10 EBI-368321,EBI-5292994 ZSCAN1  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription coactivator activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
11 EBI-368321,EBI-747844 RAB3IP  
  .positive regulation of GTPase activity
.cilium assembly
.protein localization to organelle
  + 3 more...
.Rab guanyl-nucleotide exchange factor activity .ciliary basal body
.lamellipodium
.cytoskeleton
  + 3 more...
12 EBI-368321,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
bladder100
bone13
brain11
cervix41
connective tissue6
embryonic tissue14
esophagus99
eye71
heart55
intestine17
kidney4
larynx213
liver9
lung65
mammary gland158
mouth90
ovary19
pancreas46
pharynx98
placenta3
prostate36
skin42
stomach20
testis13
thyroid107
trachea57
uterus21
Health State
TissuesTPM*
normal21
bladder carcinoma56
breast (mammary gland) tumor107
chondrosarcoma12
colorectal tumor8
esophageal tumor115
gastrointestinal tumor16
germ cell tumor15
glioma9
head and neck tumor141
leukemia10
liver tumor20
lung tumor97
non-neoplasia62
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma43
skin tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult45
embryoid body28
fetus8
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.6
adrenal gland1.9
appendix1.2
cerebral cortex3.6
colon5.4
duodenum6.2
esophagus418.8
gallbladder9.1
heart muscle2.4
kidney8.8
liver5.3
lung22.5
ovary5.7
pancreas5.7
placenta7.3
prostate14.2
salivary gland18.5
skin107.8
small intestine6.1
stomach9.1
testis3.1
thyroid gland15.9
urinary bladder14.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602871, gene) Periplakin; PPLOMIM


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