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> Protein (NX_O60443)
Protein (NX_O60443)
Protein
Gene SymbolDFNA5 to neXtProt (NX_O60443)
DescriptionNon-syndromic hearing impairment protein 5
Chromosome7
Location7p15.3 (24737972 ~ 24809244) to Ensembl
Sequene Features : Isoforms 3, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.inner ear receptor cell differentiation
.negative regulation of cell proliferation
  + 2 more...
.N/A .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 72 1
2014-09-19protein level
3 57 1
2014-05-27protein level
3 57 1
2014-02-25protein level
3 57 1
2013-12-09protein level
3 45 1
2013-11-01protein level
3 43 1
2013-09-12protein level
3 43 1
2013-08-17protein level
3 43 1
2013-07-15protein level
3 27 1
2013-06-11protein level
3 27 1
2013-02-12protein level
3 17 1
2012-12-20protein level
3 17 1
2012-10-30protein level
3 25 1
2012-10-07protein level
3 25 1
2012-08-24protein level
2 23 1
2012-07-28protein level
2 23 1
2012-06-08protein level
2 23 1
2012-05-07protein level
2 23 1
2012-04-10protein level
2 23 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 0
2011-08-23protein level
2 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60443-1
10 15 0 54520.1955
NX_O60443-2
1 4 0 10898.7798
NX_O60443-3
0 15 0 36019.4596
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood81
bone69
bone marrow20
brain84
cervix20
connective tissue60
embryonic tissue14
esophagus49
eye67
heart55
kidney118
larynx42
liver34
lung35
mammary gland13
mouth75
muscle65
ovary9
pancreas23
pituitary gland121
placenta127
prostate15
skin33
testis45
thymus37
trachea19
uterus56
vascular58
Health State
TissuesTPM*
normal58
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma120
esophageal tumor57
gastrointestinal tumor8
germ cell tumor94
glioma83
head and neck tumor44
kidney tumor145
leukemia21
liver tumor31
lung tumor77
lymphoma27
non-neoplasia41
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS78
prostate cancer19
skin tumor7
soft tissue/muscle tissue tumor63
uterine tumor11
Developmental Stage
TissuesTPM*
adult58
embryoid body28
neonate193
fetus39
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.6
adrenal gland8.8
appendix3.5
cerebral cortex15.1
colon3.4
duodenum7.7
esophagus4.8
gallbladder10.4
heart muscle9
kidney13.2
liver2.9
lung4.7
lymph node6
ovary19.9
placenta40.3
prostate9.4
salivary gland2.4
small intestine29.4
spleen2.1
stomach1.8
testis16.3
thyroid gland16
urinary bladder13.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateLow
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Low
skin 2Medium
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#600994, phenotype) Deafness, autosomal dominant 5; DFNA5OMIM
2(*608798, gene) Dfna5 gene; DFNA5OMIM


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