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> Protein (NX_O60500)
Protein (NX_O60500)
Protein
Gene SymbolNPHS1 to neXtProt (NX_O60500)
DescriptionNephrin
Chromosome19
Location19q13.12 (36316866 ~ 36360189) to Ensembl
Sequene Features : Isoforms 2, Variants 266, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.glomerular visceral epithelial cell development
.regulation of excretion
.glomerular basement membrane development
  + 6 more...
.myosin binding .extracellular exosome
.membrane raft
.protein complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 266 20
2014-09-19protein level
2 223 20
2014-05-27protein level
2 223 20
2014-02-25protein level
2 222 20
2013-12-09protein level
2 187 20
2013-11-01protein level
2 178 20
2013-09-12protein level
2 178 20
2013-08-17protein level
2 178 20
2013-07-15protein level
2 144 20
2013-06-11protein level
2 144 20
2013-02-12protein level
2 117 40
2012-12-20protein level
2 117 40
2012-10-30protein level
2 128 40
2012-10-07protein level
2 128 20
2012-08-24protein level
2 107 20
2012-07-28protein level
2 107 20
2012-06-08protein level
2 107 20
2012-05-07protein level
2 104 20
2012-04-10protein level
2 104 20
2012-01-13protein level
2 92 20
2011-12-20protein level
2 92 20
2011-11-11protein level
2 92 20
2011-08-23protein level
2 92 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60500-1
2 50 0 134658.0799
NX_O60500-2
1 50 0 130464.6787
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-996920,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-996920,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
kidney18
lung5
pancreas9
testis2
thymus25
uterus4
Health State
TissuesTPM*
normal1
kidney tumor14
uterine tumor11
Developmental Stage
TissuesTPM*
adult1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
kidney22.3
lymph node4.3
pancreas13.2
testis1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowMedium
breastLow
bronchusMedium
cerebellumLow
cerebral cortexLow
colonLow
duodenumLow
epididymisMedium
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleMedium
lungMedium
lymph nodeLow
nasopharynxMedium
pancreasLow
placentaMedium
prostateLow
rectumLow
skin 1Medium
small intestineLow
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
stomach 1Low
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#256300, phenotype) Nephrotic syndrome, type 1; NPHS1OMIM
2(*602716, gene) Nephrin; NPHS1OMIM


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