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> Protein (NX_O60504)
Protein (NX_O60504)
Protein
Gene SymbolSORBS3 to neXtProt (NX_O60504)
DescriptionVinexin
Chromosome8
Location8p21.3 (22402499 ~ 22433301) to Ensembl
Sequene Features : Isoforms 2, Variants 101, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 101 15
2014-09-19protein level
2 89 15
2014-05-27protein level
2 89 15
2014-02-25protein level
2 89 15
2013-12-09protein level
2 53 15
2013-11-01protein level
2 50 15
2013-09-12protein level
2 50 15
2013-08-17protein level
2 50 15
2013-07-15protein level
2 40 15
2013-06-11protein level
2 40 15
2013-02-12protein level
2 26 26
2012-12-20protein level
2 23 26
2012-10-30protein level
2 30 26
2012-10-07protein level
2 30 14
2012-08-24protein level
2 30 14
2012-07-28protein level
2 29 14
2012-06-08protein level
2 33 14
2012-05-07protein level
2 32 14
2012-04-10protein level
2 32 14
2012-01-13protein level
2 20 14
2011-12-20protein level
2 20 14
2011-11-11protein level
2 20 10
2011-08-23protein level
2 20 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60504-1
14 19 0 75294.6896
NX_O60504-2
0 19 0 36719.3816
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741237,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-1222956,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
3 EBI-741237,EBI-740434 ZBTB7B  
  .cell differentiation
.positive regulation of gene expression
.ectoderm development
  + 3 more...
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
4 EBI-1222953,EBI-1384248 INPPL1  
  .ruffle assembly
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 13 more...
.SH2 domain binding
.hydrolase activity
.filopodium
.lamellipodium
.plasma membrane
  + 4 more...
5 EBI-1222956,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
6 EBI-1222956,EBI-2568901 RARG  
  .cellular response to retinoic acid
.Harderian gland development
.prostate gland epithelium morphogenesis
  + 26 more...
.retinoid X receptor binding
.zinc ion binding
.retinoic acid receptor activity
  + 4 more...
.integral component of membrane
.transcription factor complex
.nucleoplasm
  + 2 more...
7 EBI-741237,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
8 EBI-741237,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
9 EBI-741237,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
10 EBI-1222956,EBI-352869 SAFB2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.extracellular exosome
.intracellular membrane-bounded organelle
.cytoplasm
.nucleoplasm
11 EBI-741237,EBI-10233719 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
12 EBI-741237,EBI-10244997 VARS2  
  .gene expression
.valyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.valine-tRNA ligase activity
.aminoacyl-tRNA editing activity
.mitochondrion
13 EBI-741237,EBI-739493 KIAA0408  
  .N/A .N/A .N/A
14 EBI-741237,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
15 EBI-741237,EBI-7097057 CPNE2  
  .N/A .N/A .extracellular exosome
16 EBI-1222956,EBI-446694 RTKN  
  .negative regulation of GTPase activity
.septin cytoskeleton organization
.Rho protein signal transduction
  + 3 more...
.GTP-Rho binding
.GTP binding
.GTPase inhibitor activity
.cytosol
17 EBI-741237,EBI-1018153 HNRNPUL1  
  .gene expression
.response to virus
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.enzyme binding
.RNA binding
.ribonucleoprotein complex
.nucleoplasm
.nucleus
18 EBI-741237,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
19 EBI-741237,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
20 EBI-741237,EBI-747993 ZC4H2  
  .spinal cord motor neuron differentiation
.neuromuscular junction development
.nervous system development
.metal ion binding .postsynaptic membrane
.cell junction
.cytoplasm
.nucleus
21 EBI-741237,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
22 EBI-741237,EBI-745080 NCKIPSD  
  .innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
.small GTPase mediated signal transduction
  + 3 more...
.cytoskeletal protein binding .intermediate filament
.cytosol
.nucleus
23 EBI-1222956,EBI-4290615 WASF2  
  .lamellipodium morphogenesis
.negative regulation of stress fiber assembly
.vascular endothelial growth factor receptor signaling pathway
  + 13 more...
.protein complex binding
.actin binding
.extracellular exosome
.SCAR complex
.lamellipodium
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder33
blood49
bone97
bone marrow20
brain44
cervix41
connective tissue46
embryonic tissue75
esophagus49
eye95
heart44
intestine47
kidney80
larynx85
liver43
lung77
lymph22
mammary gland39
mouth30
muscle9
nerve193
ovary157
pancreas70
pituitary gland60
placenta77
prostate84
salivary gland493
skin37
spleen168
stomach10
testis68
thyroid128
trachea57
uterus43
vascular38
Health State
TissuesTPM*
normal60
bladder carcinoma56
breast (mammary gland) tumor53
chondrosarcoma132
colorectal tumor35
esophageal tumor57
gastrointestinal tumor33
germ cell tumor18
glioma158
head and neck tumor112
kidney tumor116
leukemia42
liver tumor72
lung tumor97
lymphoma124
non-neoplasia62
ovarian tumor144
pancreatic tumor95
primitive neuroectodermal tumor of the CNS165
prostate cancer19
skin tumor39
soft tissue/muscle tissue tumor71
uterine tumor22
Developmental Stage
TissuesTPM*
adult87
embryoid body100
blastocyst48
fetus34
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue127.7
adrenal gland46.5
appendix39.9
bone marrow5.5
cerebral cortex44.9
colon60.9
duodenum35
esophagus46.3
gallbladder70.5
heart muscle69.8
kidney54.9
liver70.2
lung96.9
lymph node36.6
ovary92.2
pancreas23.5
placenta104.6
prostate87.1
salivary gland61.4
skin57.2
small intestine45.1
spleen67.3
stomach39.3
testis161
thyroid gland47.9
urinary bladder50.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610795, gene) Sorbin and sh3 domains-containing 3; SORBS3OMIM


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2014-2019 (C) Yonsei Proteome Research Center