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> Protein (NX_O60566)
Protein (NX_O60566)
Protein
Gene SymbolBUB1B to neXtProt (NX_O60566)
DescriptionMitotic checkpoint serine/threonine-protein kinase BUB1 beta
Chromosome15
Location15q15.1 (40453224 ~ 40513337) to Ensembl
Sequene Features : Isoforms 3, Variants 110, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.cell division
  + 10 more...
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.spindle midzone
.perinuclear region of cytoplasm
.cytosol
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 110 13
2014-09-19protein level
3 94 13
2014-05-27protein level
3 93 13
2014-02-25protein level
3 92 13
2013-12-09protein level
3 75 13
2013-11-01protein level
3 70 12
2013-09-12protein level
3 70 12
2013-08-17protein level
3 70 12
2013-07-15protein level
3 56 10
2013-06-11protein level
3 56 10
2013-02-12protein level
3 35 29
2012-12-20protein level
3 35 29
2012-10-30protein level
3 42 29
2012-10-07protein level
3 42 10
2012-08-24protein level
3 42 10
2012-07-28protein level
3 42 10
2012-06-08protein level
3 24 10
2012-05-07protein level
3 24 10
2012-04-10protein level
3 24 10
2012-01-13protein level
3 24 10
2011-12-20protein level
3 25 10
2011-11-11protein level
3 25 10
2011-08-23protein level
3 25 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60566-1
0 52 0 119469.6613
NX_O60566-2
3 43 0 105823.0109
NX_O60566-3
0 52 0 121309.6204
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1001438,EBI-1050987 BUB3  
  .spindle assembly checkpoint
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 8 more...
.N/A .cytosol
.nucleoplasm
.condensed chromosome kinetochore
.kinetochore
2 EBI-1001438,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-1001438,EBI-1375040 CENPE  
  .kinetochore assembly
.attachment of mitotic spindle microtubules to kinetochore
.cell division
  + 12 more...
.kinetochore binding
.ATPase activity
.ATP binding
.microtubule motor activity
.mitotic spindle midzone
.midbody
.membrane
  + 12 more...
4 EBI-1001438,EBI-367462 CDC20  
  .positive regulation of synapse maturation
.activation of anaphase-promoting complex activity
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 14 more...
.enzyme binding
.protein C-terminus binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 6 more...
5 EBI-1001438,EBI-477232 SIRT2  
  .positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
.negative regulation of reactive oxygen species metabolic process
.ripoptosome assembly involved in necroptotic process
  + 55 more...
.NAD+ binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
.ubiquitin binding
  + 10 more...
.glial cell projection
.meiotic spindle
.mitotic spindle
  + 21 more...
6 EBI-1001438,EBI-477430 KAT2B  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood40
bone97
bone marrow20
brain18
cervix82
connective tissue6
embryonic tissue164
esophagus49
heart22
intestine30
kidney28
liver14
lung29
lymph22
lymph node111
mammary gland39
mouth151
muscle18
ovary9
placenta31
skin42
stomach10
testis119
thymus150
tonsil58
uterus12
Health State
TissuesTPM*
normal30
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor115
chondrosarcoma60
colorectal tumor35
esophageal tumor57
gastrointestinal tumor25
germ cell tumor79
glioma9
head and neck tumor67
kidney tumor14
leukemia74
liver tumor20
lymphoma69
non-neoplasia10
ovarian tumor13
primitive neuroectodermal tumor of the CNS39
skin tumor71
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult21
embryoid body114
blastocyst276
fetus53
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.2
appendix8.2
bone marrow21.2
cerebral cortex1.1
colon6.2
duodenum5.6
esophagus4.4
gallbladder1.7
lung1.3
lymph node13.8
placenta4.1
prostate1.6
skin4.5
small intestine4.6
spleen2.5
stomach4.1
testis29.4
thyroid gland1.2
urinary bladder3.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#176430, phenotype) Premature chromatid separation trait; PCSOMIM
2(#257300, phenotype) Mosaic variegated aneuploidy syndrome 1; MVA1OMIM
3(*602860, gene) Budding uninhibited by benzimidazoles 1, s. cerevisiae, homolog of,OMIM
4rhabdomyosarcoma;Mosaic variegated aneuploidyCGP


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