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> Protein (NX_O60568)
Protein (NX_O60568)
Protein
Gene SymbolPLOD3 to neXtProt (NX_O60568)
DescriptionProcollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Chromosome7
Location7q22.1 (100849258 ~ 100861701) to Ensembl
Sequene Features : Isoforms 1, Variants 103, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.basement membrane assembly
.lung morphogenesis
.epidermis morphogenesis
  + 9 more...
.procollagen galactosyltransferase activity
.procollagen glucosyltransferase activity
.L-ascorbic acid binding
  + 2 more...
.extracellular exosome
.rough endoplasmic reticulum membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 103 2
2014-09-19protein level
1 88 2
2014-05-27protein level
1 88 2
2014-02-25protein level
1 87 2
2013-12-09protein level
1 64 2
2013-11-01protein level
1 60 2
2013-09-12protein level
1 60 2
2013-08-17protein level
1 60 2
2013-07-15protein level
1 47 2
2013-06-11protein level
1 47 2
2013-02-12protein level
1 31 2
2012-12-20protein level
1 31 2
2012-10-30protein level
1 34 2
2012-10-07protein level
1 34 2
2012-08-24protein level
1 30 2
2012-07-28protein level
1 30 2
2012-06-08protein level
1 30 2
2012-05-07protein level
1 30 2
2012-04-10protein level
1 30 2
2012-01-13protein level
1 12 2
2011-12-20protein level
1 12 2
2011-11-11protein level
1 12 2
2011-08-23protein level
1 12 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60568-1
40 0 0 84731.2352
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741582,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
2 EBI-741582,EBI-747844 RAB3IP  
  .positive regulation of GTPase activity
.cilium assembly
.protein localization to organelle
  + 3 more...
.Rab guanyl-nucleotide exchange factor activity .ciliary basal body
.lamellipodium
.cytoskeleton
  + 3 more...
3 EBI-741582,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland273
ascites1079
blood89
bone195
bone marrow123
brain150
cervix82
connective tissue201
embryonic tissue103
esophagus99
eye62
heart78
intestine176
kidney189
liver82
lung116
lymph22
lymph node77
mammary gland152
mouth241
muscle47
nerve64
ovary266
pancreas135
pituitary gland60
placenta144
prostate110
salivary gland49
skin322
spleen318
stomach83
testis71
thymus125
thyroid236
tonsil117
trachea38
umbilical cord290
uterus56
vascular387
Health State
TissuesTPM*
normal124
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor204
chondrosarcoma217
colorectal tumor186
esophageal tumor115
gastrointestinal tumor472
germ cell tumor208
glioma317
head and neck tumor164
kidney tumor130
leukemia116
liver tumor124
lung tumor48
lymphoma13
non-neoplasia113
ovarian tumor328
pancreatic tumor95
primitive neuroectodermal tumor of the CNS322
prostate cancer96
retinoblastoma43
skin tumor223
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult145
embryoid body114
blastocyst146
neonate772
fetus107
juvenile377
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.1
adrenal gland16.9
appendix30.1
bone marrow15.8
cerebral cortex14
colon24.4
duodenum26.2
esophagus13.1
gallbladder25.2
heart muscle18.2
kidney15
liver16.5
lung24.3
lymph node18.7
ovary13.2
pancreas9.8
placenta35.3
prostate15.7
salivary gland7.8
skin17.3
small intestine28.4
spleen29.3
stomach22.1
testis13.7
thyroid gland19.3
urinary bladder25.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603066, gene) Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; PLOD3OMIM
2(#612394, phenotype) Bone fragility with contractures, arterial rupture, and deafnessOMIM


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