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> Protein (NX_O60573)
Protein (NX_O60573)
Protein
Gene SymbolEIF4E2 to neXtProt (NX_O60573)
DescriptionEukaryotic translation initiation factor 4E type 2
Chromosome2
Location2q37.1 (233414762 ~ 233448354) to Ensembl
Sequene Features : Isoforms 2, Variants 28, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 28 5
2014-09-19protein level
2 23 5
2014-05-27protein level
2 23 5
2014-02-25protein level
1 21 4
2013-12-09protein level
1 17 4
2013-11-01protein level
1 14 3
2013-09-12protein level
1 14 2
2013-08-17protein level
1 14 1
2013-07-15protein level
1 10 1
2013-06-11protein level
1 10 1
2013-02-12protein level
1 2 1
2012-12-20protein level
1 2 1
2012-10-30protein level
1 1 1
2012-10-07protein level
1 1 1
2012-08-24protein level
1 1 1
2012-07-28protein level
1 1 1
2012-06-08protein level
1 13 1
2012-05-07protein level
1 18 1
2012-04-10protein level
1 18 1
2012-01-13protein level
1 12 1
2011-12-20protein level
1 13 1
2011-11-11protein level
1 13 1
2011-08-23protein level
1 13 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60573-1
1 10 0 28344.1072
NX_O60573-2
0 10 0 27009.284
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-398610,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-398610,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
3 EBI-398610,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
4 EBI-398610,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
5 EBI-398610,EBI-3906629 MYOG  
  .positive regulation of myoblast fusion
.regulation of myoblast fusion
.cellular response to estradiol stimulus
  + 23 more...
.E-box binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 8 more...
.protein-DNA complex
.transcription factor complex
.nucleoplasm
.nucleus
6 EBI-398610,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
7 EBI-398610,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
8 EBI-398610,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
9 EBI-398610,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
10 EBI-398610,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
11 EBI-398610,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
12 EBI-398610,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
13 EBI-398610,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
14 EBI-398610,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
15 EBI-398610,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-398610,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
17 EBI-398610,EBI-946185 USP54  
  .ubiquitin-dependent protein catabolic process .ubiquitinyl hydrolase activity .N/A
18 EBI-398610,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
19 EBI-398610,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
20 EBI-398610,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
21 EBI-398610,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
22 EBI-398610,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
23 EBI-398610,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
24 EBI-398610,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
25 EBI-398610,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
26 EBI-398610,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
27 EBI-398610,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
28 EBI-398610,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
29 EBI-398610,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
30 EBI-398610,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
31 EBI-398610,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
32 EBI-398610,EBI-716006 MAGED1  
  .positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites225
bladder368
blood73
bone195
bone marrow41
brain127
cervix185
connective tissue93
embryonic tissue79
eye81
heart78
intestine103
kidney90
liver97
lung107
lymph node167
mammary gland66
mouth105
muscle197
ovary128
pancreas84
pharynx147
placenta88
prostate153
salivary gland148
skin142
spleen74
stomach62
testis174
thymus37
thyroid42
trachea96
uterus86
vascular38
Health State
TissuesTPM*
normal103
bladder carcinoma568
breast (mammary gland) tumor64
cervical tumor144
chondrosarcoma108
colorectal tumor151
gastrointestinal tumor92
germ cell tumor155
glioma55
head and neck tumor74
kidney tumor87
leukemia42
liver tumor93
lung tumor116
lymphoma13
non-neoplasia62
ovarian tumor118
pancreatic tumor85
primitive neuroectodermal tumor of the CNS94
prostate cancer221
retinoblastoma107
skin tumor183
soft tissue/muscle tissue tumor207
uterine tumor22
Developmental Stage
TissuesTPM*
adult84
embryoid body71
blastocyst162
neonate64
fetus147
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue42.5
adrenal gland28.1
appendix42.7
bone marrow33.5
cerebral cortex33.4
colon69.1
duodenum45.2
esophagus44.4
gallbladder40
heart muscle22.7
kidney57.2
liver46.3
lung36.5
lymph node40.6
ovary27.9
pancreas15.4
placenta48
prostate30
salivary gland24.6
skin35.6
small intestine41.4
spleen36.7
stomach44.5
testis38.4
thyroid gland30.5
urinary bladder39
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605895, gene) Eukaryotic translation initiation factor 4e family, member 2; EIF4E2OMIM


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