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> Protein (NX_O60636)
Protein (NX_O60636)
Protein
Gene SymbolTSPAN2 to neXtProt (NX_O60636)
DescriptionTetraspanin-2
Chromosome1
Location1p13.2 (115590632 ~ 115632121) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.axon development
.oligodendrocyte differentiation
.myelination
  + 4 more...
.N/A .myelin sheath
.integral component of membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 1
2014-09-19protein level
2 27 1
2014-05-27protein level
2 27 1
2014-02-25protein level
2 27 1
2013-12-09protein level
2 22 1
2013-11-01protein level
2 17 1
2013-09-12protein level
2 17 1
2013-08-17protein level
1 17 1
2013-07-15protein level
1 12 1
2013-06-11protein level
1 12 1
2013-02-12protein level
1 7 1
2012-12-20protein level
1 8 1
2012-10-30protein level
1 10 1
2012-10-07protein level
1 10 1
2012-08-24protein level
1 8 1
2012-07-28protein level
1 8 1
2012-06-08protein level
1 11 1
2012-05-07protein level
1 11 1
2012-04-10protein level
1 11 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 7 1
2011-11-11protein level
1 7 1
2011-08-23protein level
1 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60636-1
2 6 0 24131.2118
NX_O60636-2
1 6 0 21254.5906
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3914288,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
2 EBI-3914288,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood24
bone13
bone marrow20
brain10
embryonic tissue28
eye14
heart11
intestine8
kidney37
lung5
mammary gland6
muscle18
pancreas18
parathyroid48
placenta3
prostate26
skin4
stomach10
testis4
uterus43
Health State
TissuesTPM*
normal14
breast (mammary gland) tumor10
colorectal tumor8
gastrointestinal tumor8
germ cell tumor15
kidney tumor87
leukemia21
prostate cancer9
uterine tumor22
Developmental Stage
TissuesTPM*
adult12
embryoid body28
fetus19
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.1
adrenal gland2.1
appendix10.7
bone marrow12.6
cerebral cortex2.9
colon14.7
duodenum5.4
esophagus13.8
gallbladder8.3
heart muscle6
kidney9.9
lung7.4
lymph node1.4
ovary1.9
pancreas1.6
placenta3
prostate16
salivary gland2.2
small intestine7.1
spleen3.3
stomach6.9
testis1.7
thyroid gland2.8
urinary bladder21.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613133, gene) Tetraspanin 2; TSPAN2OMIM


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